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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
163 stopped studies mapped to Malignant Colon Neoplasm and descendants · 88% state a reason
Over the 163 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computed
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT02182466 | German Colon Capsule Registry(DEKOR) | — | terminated | Jul 8, 2014 | Johann Wolfgang Goethe University Hospital | not stated | Not stated |
| NCT02057991 | Mindfulness-Based Exercise Video in Educating Hispanic/Latino Patients With Colorectal… | N/A | terminated | Feb 7, 2014 | University of Southern California | Insufficient Accrual | Enrollment / accrual |
| NCT01606124 | Polyphenon E in Treating Patients With High-Risk of Colorectal Cancer | Phase 2 | terminated | May 25, 2012 | Mayo Clinic | pending expiration of the supply of study agent. | Drug supply |
| NCT02774512 | Predictive Biomarkers of Biological Activity and Efficacy of Nilotinib on ZAK Target in…(ZAK-0) | Early Phase 1 | withdrawn | May 17, 2016 | Institut Bergonié | none participant has been enrolled and recruited during the first year after competent autority… | Enrollment / accrual |
| NCT00003485 | Antineoplaston Therapy in Treating Patients With Metastatic or Unresectable Colon Cancer | Phase 2 | terminated | Jan 27, 2003 | Burzynski Research Institute | slow accrual | Enrollment / accrual |
| NCT01176500 | A Pilot, Open-label Study of 18F-Fluciclatide PET/CT Imaging in the Evaluation of… | Phase 1 / Phase 2 | withdrawn | Aug 6, 2010 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01386502 | CT-011 and p53 Genetic Vaccine for Advanced Solid Tumors | Phase 1 | withdrawn | Jul 1, 2011 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01936961 | Study of Immunochemotherapy +/- Hypofractionated Radiation for Complete Response in Solid…(I-CREST) | N/A | withdrawn | Sep 6, 2013 | Western Regional Medical Center | No patients enrolled | Enrollment / accrual |
| NCT01940237 | A Pilot Trial of Interpersonal Psychotherapy for the Treatment of Depression in Patients… | N/A | terminated | Sep 12, 2013 | New York State Psychiatric Institute | Low recruitment | Enrollment / accrual |
| NCT01326065 | Implementation of Laparoscopy-assisted Surgery for Colon Cancer | — | terminated | Mar 30, 2011 | Helse Stavanger HF | Study had to be terminated due to lack of funding | Funding |
| NCT01270438 | Combination Chemotherapy and Bevacizumab With or Without RO4929097 in Treating Patients… | Phase 2 | withdrawn | Jan 5, 2011 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00127036 | Trial for Microarray Analysis of Colon Cancer Outcome-A (MACCO-A) | Phase 2 | terminated | Aug 5, 2005 | H. Lee Moffitt Cancer Center and Research Institute | drug now on market | Other (stated, no rule matched) |
| NCT02301338 | Improving Health of Patients With Colon Cancer Following Surgery: A Trial of SA-ICAN Via… | — | terminated | Nov 25, 2014 | Memorial Sloan Kettering Cancer Center | Lack of accrual | Enrollment / accrual |
| NCT01163526 | Perfusion CT as a Predictor of Treatment Response in Patients With Hepatic Malignancies | — | terminated | Jul 15, 2010 | Stanford University | accrual | Enrollment / accrual |
| NCT02046538 | Phase II Study of Zaltrap and Chemotherapy for Advanced Resectable Colorectal Cancer | Phase 2 | withdrawn | Jan 27, 2014 | Weill Medical College of Cornell University | Investigator terminated due to funding issues | Investigator |
| NCT01522677 | A Study of Neoadjuvant Photodynamic Immunomodulation for Colon Cancer | Phase 1 / Phase 2 | withdrawn | Jan 31, 2012 | Edward Nelson | Slow accrual | Enrollment / accrual |
| NCT00684229 | Regional Anesthesia in Colon Rectal Surgery | N/A | withdrawn | May 26, 2008 | The Cleveland Clinic | investigator could not identify any patients | Investigator |
| NCT01969292 | Colometer - A Real Time Quality Improvement Feedback System for Screening Colonoscopy | N/A | terminated | Oct 25, 2013 | Christopher Andrews | Stage 1 Complete; Stage 2 and 3 not pursued | Other (stated, no rule matched) |
| NCT01457976 | A Survey on Attitudes on Financial Incentives | — | withdrawn | Oct 24, 2011 | University of Pennsylvania | protocol never approved by local IRB | Other (stated, no rule matched) |
| NCT01322815 | A Pilot Trial of GI-4000 Plus Bevacizumab and Either FOLFOX or FOLFIRI | Phase 2 | terminated | Mar 25, 2011 | Georgetown University | Poor accrual rate | Enrollment / accrual |
| NCT01137162 | Clinical and Pathologic Studies of Patients Undergoing Treatment With EGFR Inhibitors | — | terminated | Jun 4, 2010 | Stanford University | Low Accrual | Enrollment / accrual |
| NCT01320683 | Combination Chemotherapy and Bevacizumab Before Surgery and Radiolabeled Monoclonal… | Phase 2 | terminated | Mar 22, 2011 | City of Hope Medical Center | Slow accrual. | Enrollment / accrual |
| NCT01111292 | Inositol in Preventing Colorectal Cancer in Patients With Colitis-Associated Dysplasia | Phase 1 / Phase 2 | terminated | Apr 27, 2010 | National Cancer Institute (NCI) | The study was closed prematurely due to poor accrual. | Enrollment / accrual |
| NCT01339000 | Improving the Immune System With Human IL-7 Vaccine in Older Subjects Who Have Had… | Phase 2 | terminated | Apr 20, 2011 | National Cancer Institute (NCI) | Company supplying drug declared bankruptcy, thus there was no drug supply. | Drug supply |
| NCT02575508 | Pan FGFR Kinase Inhibitor BGJ398 and Combination Chemotherapy in Treating Patients With… | Phase 1 / Phase 2 | withdrawn | Oct 14, 2015 | Roswell Park Cancer Institute | drug supply issues | Drug supply |
| NCT02317731 | Effect of Use of Straw on Tolerability and Quality of Split Dose 4l-PEG Preparation | N/A | terminated | Dec 16, 2014 | Yale University | PI relocated | Other (stated, no rule matched) |
| NCT00865527 | Pilot Study of Colon Cancer Screening Tests | N/A | terminated | Mar 19, 2009 | Hamilton Health Sciences Corporation | Lack of ongoing funding | Funding |
| NCT01186705 | Clinical And Translational Study Of MK-2206 In Patients With Metastatic KRAS-Wild-Type,… | Phase 2 | terminated | Aug 23, 2010 | Memorial Sloan Kettering Cancer Center | Lack of accrual | Enrollment / accrual |
| NCT01062919 | Local Anesthetic Wound Infusion and Functional Recovery After Colon Surgery | N/A | terminated | Feb 4, 2010 | Franco Carli | Low recruitment rate - \>70% of colorectal procedures are done laparoscopically | Enrollment / accrual |
| NCT01238965 | Panobinostat and Fluorouracil Followed By Leucovorin Calcium in Treating Patients With… | Phase 1 | terminated | Nov 11, 2010 | University of Southern California | Adverse Events | Safety / toxicity |
| NCT01198535 | Phase I Study of Cetuximab With RO4929097 in Metastatic Colorectal Cancer | Phase 1 | terminated | Sep 10, 2010 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT02235324 | Ziv-Aflibercept Followed by Ziv-Aflibercept, Fluorouracil, and Leucovorin Calcium in… | Phase 2 | withdrawn | Sep 9, 2014 | University of Southern California | Lack of funding | Funding |
| NCT00826800 | Neoadjuvant FOLFOX Plus Bevacizumab Chemotherapy in Patients With Locally Advanced Colon… | N/A | terminated | Jan 22, 2009 | Memorial Sloan Kettering Cancer Center | Lack of accrual | Enrollment / accrual |
| NCT01882972 | Strength for Health | N/A | withdrawn | Jun 21, 2013 | Loyola University | investigator left Loyola | Investigator |
| NCT01440127 | Impact of Pretreatment With Metformin on Colorectal Cancer Stem Cells (CCSC) and Related… | Phase 1 | terminated | Sep 26, 2011 | Tufts Medical Center | Unable to accrue all planned subjects in a timely fashion, but data collected will still be… | Enrollment / accrual |
| NCT01149434 | Study of JI-101 in Patients With Advanced Low Grade Endocrine Tumors, Ovarian Cancers or… | Phase 1 / Phase 2 | terminated | Jun 23, 2010 | University of Utah | Lack of drug efficacy | Efficacy / futility |
| NCT01365910 | Linifanib in Treating Patients With Advanced, Refractory Colorectal Cancer | Phase 2 | terminated | Jun 3, 2011 | Vanderbilt-Ingram Cancer Center | Interim analysis determined the study did not meet criteria to proceed | Efficacy / futility |
| NCT00499369 | Irinotecan and Cetuximab With or Without Bevacizumab in Treating Patients With Metastatic… | Phase 3 | terminated | Jul 11, 2007 | National Cancer Institute (NCI) | Due to inadequate accrual, study was terminated and limited outcome data was reported. | Enrollment / accrual |
| NCT01198548 | High-Dose Cholecalciferol in Treating Patients Receiving Combination Chemotherapy and… | Phase 2 | terminated | Sep 10, 2010 | Roswell Park Cancer Institute | Lack of funding | Funding |
| NCT01941173 | Short-Infusion Ziv-aflibercept in Treating Patients With Metastatic Colorectal Cancer… | N/A | withdrawn | Sep 13, 2013 | City of Hope Medical Center | Lack of accrual | Enrollment / accrual |
| NCT00835679 | Cetuximab and/or Dasatinib in Patients With Colorectal Cancer and Liver Metastases That… | Early Phase 1 | terminated | Feb 4, 2009 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01233505 | Veliparib, Oxaliplatin, and Capecitabine in Treating Patients With Advanced Solid Tumors | Phase 1 | terminated | Nov 3, 2010 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00088933 | Vaccine Therapy and Sargramostim With or Without Docetaxel in Treating Patients With… | Phase 1 | terminated | Aug 5, 2004 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01320267 | Single Port Laparoscopic Colectomy(SILS) | Phase 1 / Phase 2 | withdrawn | Mar 22, 2011 | University of British Columbia | Industry Funding Withdrawn | Funding |
| NCT01403103 | Cholecalciferol(25-[OH]-Vitamin D) in Treating Patients With Colorectal Cancer | Early Phase 1 | withdrawn | Jul 27, 2011 | Case Comprehensive Cancer Center | Slow Accrual | Enrollment / accrual |
| NCT01344902 | An Open Dose-finding Study of Oral Applied Hexaminolevulinate (HAL) Imaging in Patients… | Phase 1 / Phase 2 | terminated | Apr 29, 2011 | Photocure | The study was stopped due to inadequate efficacy after 13 patients were evaluated. | Efficacy / futility |
| NCT00003486 | Antineoplaston Therapy in Treating Patients With Colon Cancer | Phase 2 | withdrawn | Jan 27, 2003 | Burzynski Research Institute | not stated | Not stated |
| NCT00937482 | Cediranib Maleate and Whole Brain Radiation Therapy in Patients With Brain Metastases… | Phase 1 | terminated | Jul 13, 2009 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00002796 | Phase I-II Study of Fluorouracil in Combination With Phenylbutyrate in Advanced… | Phase 1 / Phase 2 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00070122 | Combination Chemotherapy and Bevacizumab in Treating Patients With Locally Advanced,… | Phase 3 | terminated | Oct 7, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 22 days agoSource updated Dec 15, 2017source: clinicaltrials