Clinical trial · Interventional
Pilot Study of Colon Cancer Screening Tests
Randomized Comparison of Virtual Colonoscopy, Optical Colonoscopy, and Fecal Occult Blood Testing for Colorectal Cancer Screening: a Pilot Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Lack of ongoing funding
Summary
Brief summary (as posted)
Colon cancer is the second leading cause of cancer death in North America. These deaths are preventable with proper screening. Fecal occult blood testing, virtual colonoscopy, and standard (optical) colonoscopy are all options for colon cancer screening, but it is not known which is the best at preventing death from colon cancer. A large study comparing these three tests is desperately needed. In this pilot study, the investigators want to find out what percentage of patients will show up for their screening test once enrolled. This will provide crucial information for the successful execution of the larger study.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Adenomatous Polyps | Adenomatous Polyp | ALIAS | 0.90 |
| Colon Cancer | Malignant Colon Neoplasm | CURATED_EXACT | 0.92 |
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Fecal occult blood test | Other | — | UNRESOLVED |
| Optical colonoscopy | Procedure | — | UNRESOLVED |
| Virtual colonoscopy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- ACTIVE_COMPARATOR
- label
- Fecal Occult Blood Test
- description
- fecal occult blood test
- interventionNames
- Other: Fecal occult blood test
- type
- ACTIVE_COMPARATOR
- label
- Virtual Colonoscopy
- description
- virtual colonoscopy
- interventionNames
- Procedure: Virtual colonoscopy
- type
- ACTIVE_COMPARATOR
- label
- Optical Colonoscopy
- description
- optical (conventional / endoscopic) colonoscopy
- interventionNames
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 50 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: * All individuals age 50 to 70 years Exclusion Criteria: * Unable to give informed consent * History of colorectal cancer * History of adenomatous polyp * History of inflammatory bowel disease * Prior participation in FOBT screening * Prior refusal to participate in FOBT screening * Flexible sigmoidoscopy within the previous 3 years * Virtual colonoscopy within the previous 3 years * Optical colonoscopy within the previous 3 years * Severe of terminal illness that would preclude benefit from colon cancer screening
References
Publications (2)
- DERIVEDYou JJ, Liu Y, Kirby J, Vora P, Moayyedi P. Virtual colonoscopy, optical colonoscopy, or fecal occult blood testing for colorectal cancer screening: results of a pilot randomized controlled trial. Trials. 2015 Jul 9;16:296. doi: 10.1186/s13063-015-0826-7. PMID 26156248
- DERIVEDWong AD, Kirby J, Guyatt GH, Moayyedi P, Vora P, You JJ. Randomized controlled trial comparing telephone and mail follow-up for recruitment of participants into a clinical trial of colorectal cancer screening. Trials. 2013 Feb 11;14:40. doi: 10.1186/1745-6215-14-40. PMID 23399518