Clinical trial · Interventional
Regional Anesthesia in Colon Rectal Surgery
Regional Anesthesia in Patients Undergoing Colon-Rectal Surgery
NCT00684229CI-TRIAL-00023884withdrawnN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): investigator could not identify any patients
Summary
Brief summary (as posted)
This study will compare recurrence rates in patients with colorectal cancer who will be randomly assigned to epidural anesthesia/analgesia combined with general anesthesia or to general anesthesia followed by opioid analgesia.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colon Cancer | Malignant Colon Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| general anesthesia followed by opioid analgesia | Drug | — | UNRESOLVED |
| Regional anesthesia and analgesia | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Regional anesthesia and analgesia
- description
- Regional anesthesia and analgesia (either epidural or paravertebral anesthesia).
- interventionNames
- Procedure: Regional anesthesia and analgesia
- type
- ACTIVE_COMPARATOR
- label
- general anesthesia followed by opioid analgesia
- description
- Subjects randomized to arm 2 will receive general anesthesia followed by opioid analgesia.
- interventionNames
- Drug: general anesthesia followed by opioid analgesia
Primary outcomes (1)
- measure
- cancer recurrence
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 85 Years
Show eligibility criteria text
Inclusion Criteria: * Primary colon cancer without known extension beyond colon (T3, N0, M0) * Scheduled for open, laparoscopic assisted and laparoscopic resection of the colon. * Written informed consent, including willingness to be randomized to epidural anesthesia/analgesia or to sevoflurane general anesthesia and postoperative opioid analgesia. Exclusion Criteria: * Previous surgery for colon cancer; * Any contraindication to epidural anesthesia or analgesia (including coagulopathy, abnormal anatomy); * Any contraindication to midazolam, propofol, sevoflurane, fentanyl, or morphine; * Age \<18 or \>85 years old; * ASA Physical Status ≥4; * Other cancer not believed by the attending surgeon to be in long-term remission; * Systemic disease believed by the attending surgeon or anesthesiologist to present ≥25% two-year mortality.
References
Publications (0)
Data not yet available
No reference posted for this study.