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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
401 stopped studies mapped to Breast Carcinoma and descendants · 95% state a reason
Over the 401 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT01936961 | Study of Immunochemotherapy +/- Hypofractionated Radiation for Complete Response in Solid…(I-CREST) | N/A | withdrawn | Sep 6, 2013 | Western Regional Medical Center | No patients enrolled | Enrollment / accrual |
| NCT01868503 | Lapatinib Ditosylate and Radiation Therapy in Treating Patients With Locally Advanced or… | Phase 2 | terminated | Jun 4, 2013 | Stanford University | Protocol modification | Other (stated, no rule matched) |
| NCT02567396 | Talazoparib in Treating Patients With Advanced or Metastatic Solid Tumors That Cannot Be… | Phase 1 | withdrawn | Oct 5, 2015 | National Cancer Institute (NCI) | Other- Protocol moved to Disapproved | Other (stated, no rule matched) |
| NCT02483377 | Patient Navigation and Tailored Treatment Planning in Latina Patients With Breast Cancer | — | terminated | Jun 26, 2015 | University of Southern California | Principal Investigator left | Investigator |
| NCT01729832 | Stereotactic Image-Guided Navigation During Breast Reconstruction in Patients With Breast… | N/A | withdrawn | Nov 20, 2012 | Ohio State University Comprehensive Cancer Center | not stated | Not stated |
| NCT02370264 | Questionnaires in Identifying Upper Extremity Function and Quality of Life After… | N/A | terminated | Feb 24, 2015 | University of Southern California | Study not progressing toward scientific goals | Other (stated, no rule matched) |
| NCT01151449 | Gamma-secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With… | Phase 2 | terminated | Jun 28, 2010 | National Cancer Institute (NCI) | Administratively Complete | Other (stated, no rule matched) |
| NCT01729884 | Vaccine Therapy in Treating Patients With Stage IV Hormone Receptor Positive Breast Cancer | Phase 2 | terminated | Nov 20, 2012 | University of Washington | Study ended early due to slow enrollment | Enrollment / accrual |
| NCT02685306 | A Study of Neoadjuvant Paclitaxel in Combination With Bavituximab in Early- Stage Triple-… | Phase 2 | withdrawn | Feb 18, 2016 | Peregrine Pharmaceuticals | not stated | Not stated |
| NCT01640847 | MRI Guided High Intensity Focused Ultrasound (HIFU) and ThermoDox for Palliation of… | Phase 2 | withdrawn | Jul 16, 2012 | Imunon | not stated | Not stated |
| NCT02213744 | MM-302 Plus Trastuzumab vs. Chemotherapy of Physician's Choice Plus Trastuzumab in…(HERMIONE) | Phase 2 / Phase 3 | terminated | Aug 11, 2014 | Merrimack Pharmaceuticals | Felt not to show benefit over control per DMC and confirmed via futility analysis | Efficacy / futility |
| NCT02661100 | A Trial of CDX-1401 in Combination With Poly-ICLC and Pembrolizumab, in Previously… | Phase 1 / Phase 2 | withdrawn | Jan 22, 2016 | Case Comprehensive Cancer Center | Drug unavailable | Other (stated, no rule matched) |
| NCT01875198 | Oncologic Impact of Splenectomy-omitting Radical Pancreatectomy in Well-selected… | N/A | terminated | Jun 11, 2013 | Yonsei University | because of difficulties of enrolling appropriate participants | Enrollment / accrual |
| NCT02539017 | The Clinical Significance of Cellular Immune Adjuvant Therapy of Triple Negative Breast… | Phase 2 | withdrawn | Sep 2, 2015 | First Affiliated Hospital Xi'an Jiaotong University | because of safety problem, this trial was stopped in the hospital | Safety / toxicity |
| NCT02627430 | Talazoparib and HSP90 Inhibitor AT13387 in Treating Patients With Metastatic Advanced… | Phase 1 | withdrawn | Dec 11, 2015 | National Cancer Institute (NCI) | Other - Protocol moved to Withdrawn | Other (stated, no rule matched) |
| NCT00998738 | Calcium and Magnesium in Preventing Peripheral Neuropathy Caused by Ixabepilone in… | Phase 3 | terminated | Oct 20, 2009 | Mayo Clinic | lack of accrual | Enrollment / accrual |
| NCT00636441 | Trial to Evaluate Genomic Expression Profiles to Direct Preoperative Chemotherapy in… | Phase 2 | terminated | Mar 14, 2008 | Duke University | Study terminated due to reproducibility issues with genomics prediction model | Other (stated, no rule matched) |
| NCT01391039 | Diagnostic Study of Early Breast Cancer Using Ultrasound | N/A | terminated | Jul 11, 2011 | Sunnybrook Health Sciences Centre | Low recruitment | Enrollment / accrual |
| NCT00148720 | Capecitabine in Women With Operable Breast Cancer | Phase 2 | terminated | Sep 8, 2005 | Dana-Farber Cancer Institute | Slow accrual | Enrollment / accrual |
| NCT01238133 | Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097, Paclitaxel, and Carboplatin… | Phase 1 | terminated | Nov 10, 2010 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01281163 | Lapatinib Ditosylate and Akt Inhibitor MK2206 in Treating Women With Metastatic Breast… | Phase 1 | terminated | Jan 21, 2011 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00857714 | Lapatinib for Treatment of Ductal Carcinoma In Situ (DCIS) of the Breast | N/A | terminated | Mar 9, 2009 | Indiana University | Terminated due to low accrual | Enrollment / accrual |
| NCT01149356 | RO4929097 And Exemestane in Treating Pre- and Postmenopausal Patients With Advanced or… | Phase 1 | terminated | Jun 23, 2010 | National Cancer Institute (NCI) | Manufacturer discontinued drug development. | Drug supply |
| NCT01569321 | Diagosis of Breast Carcinoma: Characterization of Breast Lesions With CLEARPEMSONIC :… | N/A | terminated | Apr 3, 2012 | Assistance Publique Hopitaux De Marseille | not stated | Not stated |
| NCT01071564 | RO4929097 and Vismodegib in Treating Patients With Breast Cancer That is Metastatic or… | Phase 1 | terminated | Feb 19, 2010 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00450879 | Pazopanib in Treating Patients With Newly Diagnosed or Locally and/or Regionally… | Phase 1 | terminated | Mar 22, 2007 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00132002 | Suberoylanilide Hydroxamic Acid in Treating Patients With Progressive Stage IV Breast… | Phase 2 | terminated | Aug 19, 2005 | National Cancer Institute (NCI) | Early termination for discouraging results | Other (stated, no rule matched) |
| NCT01166581 | Impact of Breast Magnetic Resonance Imaging (MRI) on Mastectomy Rates | — | terminated | Jul 21, 2010 | Summa Health System | Not enough data collected to work with | Other (stated, no rule matched) |
| NCT01791998 | Magnetic Resonance Thermal Image Guided Laser Interstitial Thermal Therapy in Treating… | N/A | withdrawn | Feb 15, 2013 | University of Chicago | Funding was time sensitive and expired. No subjects enrolled. | Enrollment / accrual |
| NCT01939483 | A Pilot Study of Irinotecan in Patients With Breast Cancer and CNS Metastases | N/A | withdrawn | Sep 11, 2013 | University of California, Irvine | Slow accrual | Enrollment / accrual |
| NCT00079326 | Trastuzumab and Ixabepilone in Treating Women With HER2-Positive Metastatic Breast Cancer | Phase 2 | terminated | Mar 10, 2004 | National Cancer Institute (NCI) | Slow accrual. | Enrollment / accrual |
| NCT00183963 | A Pilot Clinical Trial to Evaluate the Biological Activity of Fulvestrant in Breast… | Phase 2 | terminated | Sep 16, 2005 | University of Southern California | Insufficient accrual | Enrollment / accrual |
| NCT01329640 | Feasibility Study of Metronomic Chemotherapy for Locally Advanced Her2- Positive Breast… | Phase 2 | terminated | Apr 6, 2011 | Instituto do Cancer do Estado de São Paulo | not stated | Not stated |
| NCT01222377 | Endoscopic Breast Surgery in Treating Patients With Breast Cancer | N/A | terminated | Oct 18, 2010 | University of Southern California | P.I. left | Other (stated, no rule matched) |
| NCT01292083 | Azacitidine in Treating Patients With Triple Negative Stage I-IV Invasive Breast Cancer… | N/A | withdrawn | Feb 9, 2011 | University of Southern California | No accrual last 2 years | Enrollment / accrual |
| NCT01695057 | Vorinostat Before Surgery in Treating Patients With Triple-Negative Breast Cancer | N/A | withdrawn | Sep 27, 2012 | University of Southern California | Lack of funding | Funding |
| NCT00071942 | Vaccine Therapy in Treating Patients With Metastatic Breast Cancer | Phase 1 | terminated | Nov 6, 2003 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01705340 | Akt Inhibitor MK2206, Lapatinib Ditosylate, and Trastuzumab in Treating Patients With… | Phase 1 | terminated | Oct 12, 2012 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01194427 | A Study of Vorinostat and Tamoxifen in Newly Diagnosed Breast Cancer | Phase 2 | terminated | Sep 3, 2010 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Difficulty meeting patient accrual goals | Enrollment / accrual |
| NCT01219907 | Ex Vivo-Expanded HER2-Specific T Cells and Cyclophosphamide After Vaccine Therapy in… | Phase 1 | withdrawn | Oct 13, 2010 | University of Washington | not stated | Not stated |
| NCT00937482 | Cediranib Maleate and Whole Brain Radiation Therapy in Patients With Brain Metastases… | Phase 1 | terminated | Jul 13, 2009 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00039455 | Trastuzumab and Flavopiridol in Treating Patients With Metastatic Breast Cancer | Phase 1 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00016276 | Combination Chemotherapy, Surgery, and Radiation Therapy With or Without Dexrazoxane and… | Phase 3 | terminated | Sep 4, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00095888 | 3-AP and Gemcitabine in Treating Patients With Refractory Metastatic Breast Cancer | Phase 2 | terminated | Nov 9, 2004 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00817362 | Efficacy and Safety of IPI-504 With Trastuzumab Pretreated, Locally Advanced or… | Phase 2 | terminated | Jan 6, 2009 | Infinity Pharmaceuticals, Inc. | Limited efficacy response observed during interim analysis. | Efficacy / futility |
| NCT01075607 | Lymph Fluid and Blood Collection for Identification of Novel Biomarkers | — | terminated | Feb 25, 2010 | Indiana University | Halted prematurely due to lack of funding. | Funding |
| NCT01100489 | Breast-Conserving Surgery Followed by Radiation Therapy With MRI-Detected Stage I or… | Phase 2 | withdrawn | Apr 9, 2010 | Case Comprehensive Cancer Center | No accrual | Enrollment / accrual |
| NCT00712621 | Determining Quality of Life in Breast Cancer Patient After Completing… | Phase 2 | withdrawn | Jul 10, 2008 | American Scitech International | Study is withdrawn due to unavailability of eligible subject population. We will request the… | Enrollment / accrual |
| NCT00770354 | Phase II Study of AS1402 Combined With Letrozole to Treat Breast Cancer | Phase 2 | terminated | Oct 10, 2008 | Antisoma Research | not stated | Not stated |
| NCT00637364 | High Intensity Focused Ultrasound Tumor Treatment for Pancreatic Cancer Pain(HIFU Pancreas) | Phase 1 / Phase 2 | suspended | Mar 18, 2008 | CMED HIFU Development Corporation | Sponsor is not proceeding with USA human trial at this time | Other (stated, no rule matched) |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Jun 27, 2017source: clinicaltrials