Clinical trial · Interventional
Oncologic Impact of Splenectomy-omitting Radical Pancreatectomy in Well-selected Left-sided Pancreatic Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): because of difficulties of enrolling appropriate participants
Summary
Brief summary (as posted)
When distal pancreatectomy is carried out for left-sided pancreatic cancer, splenectomy is usually performed not only for margin-negative resection but also for effective clearance of the splenic hilar lymph nodes. However, there was no scientific evidence regarding the justifiability for spleen resection. Considering potential immunological function of the spleen, the investigators hypothesized that distal pancreatectomy without pancreatectomy for left-sided pancreatic cancer is superior than Distal pancreatectomy with pancreatectomy in terms of short-term perioperative outcomes and disease-specific overall survival.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Ductal Adenocarcinoma | Breast Ductal Carcinoma | ALIAS | 0.90 |
| Left-sided Pancreatic Cancer | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Radical Antegrade Modular Pancreatectomy without splenectomy | Procedure | — | UNRESOLVED |
| Radical Antegrade Modular Pancreatectomy with Splenectomy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- RAMPS
- description
- Radical Antegrade Modular Pancreatectomy with Splenectomy
- interventionNames
- Procedure: Radical Antegrade Modular Pancreatectomy with Splenectomy
- type
- ACTIVE_COMPARATOR
- label
- RAMP
- description
- Radical Antegrade Modular Pancreatectomy without splenectomy
- interventionNames
- Procedure: Radical Antegrade Modular Pancreatectomy without splenectomy
Primary outcomes (1)
- measure
- Bleeding amount
- timeFrame
- 5 hours
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 20 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: 1. Ductal adenocarcinoma 2. Age ≥20 and ≤80 3. General performance status: the Karnofsky score\> 70% or ECOG 0-1 4. Potentially Curative resection 5. Tumor size \< 3cm 6. Pancreatic cancer located on neck or body portion 7. No invasion to spleen or spleen hilum 8. No combined resection except Lt. adrenal gland 9. Distance more than 5cm (≥5cm) between tumor lateral margin and spleen hilum Exclusion Criteria: 1. Unresectable or locally advanced, metastatic case 2. Patients who do not want surgery 3. ASA (American society of anesthesiologists' physical status classification) score: ≥3 4. Patients with drug or alcohol addiction 5. Patients showing low compliance 6. Patients who not want to involve the clinical trial 7. Patients who are unable to read or understand the informed consent, sign a consent form (eg, mental retardation, blindness, illiteracy, foreign, etc.)
References
Publications (1)
- BACKGROUNDKim SH, Kang CM, Satoi S, Sho M, Nakamura Y, Lee WJ. Proposal for splenectomy-omitting radical distal pancreatectomy in well-selected left-sided pancreatic cancer: multicenter survey study. J Hepatobiliary Pancreat Sci. 2013 Mar;20(3):375-81. doi: 10.1007/s00534-012-0549-z. PMID 22911134