Clinical trial · Interventional
Magnetic Resonance Thermal Image Guided Laser Interstitial Thermal Therapy in Treating Patients With Breast Cancer
A Pilot Study to Evaluate Magnet Resonance Thermal Imageguided Interstital Thermal Therapy for Focal Ablation of Breast Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Funding was time sensitive and expired. No subjects enrolled.
Summary
Brief summary (as posted)
This pilot clinical trial studies magnetic resonance thermal image guided laser interstitial thermal therapy in treating patients with breast cancer. Magnetic resonance thermal image guided laser interstitial thermal therapy may be able to kill tumor cells by heating up the tumor cells without affecting the surrounding tissue
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Ductal Breast Carcinoma in Situ | Breast Ductal Carcinoma In Situ | ALIAS | 0.90 |
| Invasive Ductal Breast Carcinoma | Invasive Breast Carcinoma of No Special Type | ALIAS | 0.90 |
| Stage IA Breast Cancer | Malignant Breast Neoplasm | CURATED_BROADER | 0.78 |
| Stage IB Breast Cancer | Malignant Breast Neoplasm | CURATED_BROADER | 0.78 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| laser interstitial thermal therapy | Procedure | — | UNRESOLVED |
| magnetic resonance thermal imaging | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Treatment (MR-thermal image guided LITT)
- description
- Patients undergo MR-thermal image guided LITT over 1 hour.
- interventionNames
- Procedure: magnetic resonance thermal imaging
- Procedure: laser interstitial thermal therapy
Primary outcomes (3)
- measure
- Frequency of not completing the procedure due to patient's discomfort
- timeFrame
- Up to 7 days
- measure
- Observed thermal damage on skin
- timeFrame
- Up to 7 days
- description
- Moderate degree of skin burn which requires medical intervention will be considered side effects for stopping purposes.
Eligibility
Eligibility (as posted)
- Sex
- Female
Show eligibility criteria text
Inclusion Criteria: * Postmenopausal state * Histological diagnosis of breast invasive ductal carcinoma with receptor profiles obtained * MRI visible breast lesion * Unifocal cancer, less than 1.5 cm in maximum diameter (clinical stage T1), with no evidence of extensive in situ cancer surrounding the main tumor; the eligibility will be determined by the MR imaging appearance of the tumor; if the tumor (proven invasive ductal carcinoma) is a unifocal mass without additional enhancement, it will be judged eligible; however, if the tumor is associated with additional enhancement and/or a satellite focus, it will not judged ineligible, as these are signs of additional in situ or invasive cancer * Clinical stage N0 (no metastatic axillary lymph node on physical examination or imaging work-up) * Ability to give informed consent Exclusion Criteria: * Previous surgery or radiation for the ipsilateral breast cancer * Presence of any condition (e.g., metal implant, shrapnel) not compatible with MRI * Tumor located less than 1 cm from the skin or the pectoralis muscle
References
Publications (0)
Data not yet available