Publication
Comprehensive functional evaluation of variants of fibroblast growth factor receptor genes in cancer.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (5)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 5
- cancerMalignant Neoplasmcivic_curation1.00
- geneFGFR3civic_curation1.00
- variantFGFR3 G380Rcivic_curation1.00
- variantFGFR3 G697Ccivic_curation1.00
- variantFGFR3 Y373Ccivic_curation1.00
Curated evidence
Evidence citing this paper (13)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 34272467
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| FGFR1 N546K1 | ||||||||
| (oncogenic) | Malignant NeoplasmALIAS | Oncogenic | D | Supports Oncogenicity | 3 | submitted | EID11649FGFR1, FGFR2, FGFR3 and FGFR4 variants found in human cancer were introduced into NIH3T3 cells and assessed for transformation and proliferation in an integrated qualitative assessment of focus format… (full text at CIViC) PMID 34272467 · Nakamura et al., 2021 · Open in CIViC | civic |
| FGFR3 A391E2 | ||||||||
| (oncogenic) | Malignant NeoplasmALIAS | Oncogenic | D | Supports Oncogenicity | 3 | submitted | EID12849The transmembrane domain mutation A391E was tested in a series of assays for an evaluation of oncogenicity. A391E was stably transfected into 3T3 cells along with WT controls. TAS (Transformation Ac… (full text at CIViC) PMID 34272467 · Nakamura et al., 2021 · Open in CIViC | civic |
| Erdafitinib | Malignant NeoplasmALIAS | Predictive | D | Supports Sensitivity Response | 3 | submitted | EID13208NIH3T3 cells expressing FGFR3 A391E were sensitive to erdafitinib in an in vitro cell proliferation assay. IC50 calculated by comparison to a vehicle control was 5.1nM, which was lower than IC50 recor… (full text at CIViC) PMID 34272467 · Nakamura et al., 2021 · Open in CIViC | civic |
| FGFR3 G370C3 | ||||||||
| (oncogenic) | Malignant NeoplasmALIAS | Oncogenic | D | Supports Oncogenicity | 3 | submitted | EID12843The extracellular/transmembrane domain mutation G370C was tested in a series of assays for an evaluation of oncogenicity. G370C was stably transfected into 3T3 cells along with WT controls. TAS (Tra… (full text at CIViC) PMID 34272467 · Nakamura et al., 2021 · Open in CIViC | civic |
| Erdafitinib | Malignant NeoplasmALIAS | Predictive | D | Supports Sensitivity Response | 3 | submitted | EID13175In a preclinical MANO drug-sensitivity assay, 3T3 cells expressing FGFR3 G370C were treated with erdafitinib for 5 days. Erdafitinib inhibited the viability of FGFR3 G370C-expressing cells with an est… (full text at CIViC) PMID 34272467 · Nakamura et al., 2021 · Open in CIViC | civic |
| Infigratinib | Malignant NeoplasmALIAS | Predictive | D | Supports Sensitivity Response | 3 | submitted | EID13174In a preclinical MANO drug-sensitivity assay, 3T3 cells expressing FGFR3 G370C were treated with infigratinib for 5 days. Infigratinib inhibited FGFR3 G370C-expressing cells with an estimated IC50 of … (full text at CIViC) PMID 34272467 · Nakamura et al., 2021 · Open in CIViC | civic |
| FGFR3 G380R1 | ||||||||
| (oncogenic) | Malignant NeoplasmALIAS | Oncogenic | D | Supports Oncogenicity | 3 | accepted | EID12847The transmembrane domain mutation G380R was tested in a series of assays for an evaluation of oncogenicity. G380R was stably transfected into 3T3 cells along with WT controls. TAS (Transformation Ac… (full text at CIViC) PMID 34272467 · Nakamura et al., 2021 · Open in CIViC | civic |
| FGFR3 G697C1 | ||||||||
| (oncogenic) | Malignant NeoplasmALIAS | Oncogenic | D | Does Not Support Oncogenicity | 3 | accepted | EID12848The tyrosine kinase domain mutation G697C in FGFR3 was tested in a series of assays for an evaluation of oncogenicity. G697C was stably transfected into 3T3 cells along with WT controls. TAS (Transf… (full text at CIViC) PMID 34272467 · Nakamura et al., 2021 · Open in CIViC | civic |
| FGFR3 K650E1 | ||||||||
| (oncogenic) | Malignant NeoplasmALIAS | Oncogenic | D | Supports Oncogenicity | 3 | submitted | EID12845The tyrosine kinase domain mutation K650E was tested in a series of assays for an evaluation of oncogenicity. K650E was stably transfected into 3T3 cells along with WT controls. TAS (Transformation … (full text at CIViC) PMID 34272467 · Nakamura et al., 2021 · Open in CIViC | civic |
| FGFR3 K650N1 | ||||||||
| (oncogenic) | Malignant NeoplasmALIAS | Oncogenic | D | Supports Oncogenicity | 3 | submitted | EID12846The tyrosine kinase domain mutation K650N was tested in a series of assays for an evaluation of oncogenicity. K650N was stably transfected into 3T3 cells along with WT controls. TAS (Transformation … (full text at CIViC) PMID 34272467 · Nakamura et al., 2021 · Open in CIViC | civic |
| FGFR3 R248C1 | ||||||||
| (oncogenic) | Malignant NeoplasmALIAS | Oncogenic | D | Supports Oncogenicity | 3 | submitted | EID12841The extracellular domain mutation R248C was tested in a series of assays for an evaluation of oncogenicity. R248C was stably transfected into 3T3 cells along with WT controls. TAS (Transformation Ac… (full text at CIViC) PMID 34272467 · Nakamura et al., 2021 · Open in CIViC | civic |
| FGFR3 S249C1 | ||||||||
| (oncogenic) | Malignant NeoplasmALIAS | Oncogenic | D | Supports Oncogenicity | 3 | submitted | EID12842The extracellular domain mutation S249C was tested in a series of assays for an evaluation of oncogenicity. S249C was stably transfected into 3T3 cells along with WT controls. TAS (Transformation Ac… (full text at CIViC) PMID 34272467 · Nakamura et al., 2021 · Open in CIViC | civic |
| FGFR3 Y373C1 | ||||||||
| (oncogenic) | Malignant NeoplasmALIAS | Oncogenic | D | Supports Oncogenicity | 3 | accepted | EID12844The extracellular/transmembrane domain mutation Y373C was tested in a series of assays for an evaluation of oncogenicity. Y373C was stably transfected into 3T3 cells along with WT controls. TAS (Tra… (full text at CIViC) PMID 34272467 · Nakamura et al., 2021 · Open in CIViC | civic |