Variant · Snv
FGFR3 K650N
CI-VAR-00002160Explore in graph →NP_000133.1:p.Lys650AsnNM_000142.5:c.1950G>CClinVar 16347 CIViC 3695
Curated evidence
Evidence by cancer (3 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 34272467
- Run
- ING-CIVIC-20260908-000001
| Molecular profile | Therapy | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| Malignant Neoplasm1 | ||||||||
| FGFR3 K650N | (oncogenic) | Oncogenic | D | Supports Oncogenicity | 3 | submitted | EID12846The tyrosine kinase domain mutation K650N was tested in a series of assays for an evaluation of oncogenicity. K650N was stably transfected into 3T3 cells along with WT controls. TAS (Transformation … (full text at CIViC) PMID 34272467 · Nakamura et al., 2021 · Open in CIViC | civic |
| Unmapped disease2unmapped disease | ||||||||
| FGFR3 K650N | (functional) | Functional | D | Supports Gain Of Function | 3 | submitted | EID1008725 FGFR3 mutant proteins were isolated and their auto-phosphorylation and kinase activity was measured and compared to wild-type. 6 mutations (N540K, N540S, K650E, K650N, R669G, R669Q) demonstrated in… (full text at CIViC) PMID 26992226 · | |
ClinVar
Clinical significance (0)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
Data not yet available