Variant · Snv
FGFR3 G697C
CI-VAR-00001788Explore in graph →NP_000133.1:p.Gly697CysNM_000142.5:c.2089G>TClinVar 376248 CIViC 4030
Curated evidence
Evidence by cancer (4 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 24626198
- Run
- ING-CIVIC-20260908-000001
| Molecular profile | Therapy | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| Malignant Neoplasm3 | ||||||||
| FGFR3 G697C | (oncogenic) | Oncogenic | D | Does Not Support Oncogenicity | 3 | accepted | EID10838In human skin grafts, FGFR3, R248C, and S249C, but not G697C induced MAPK activation and hyperproliferation. The authors conclude that G697C is likely not an oncodriver and may be a geographically ass… (full text at CIViC) PMID 24626198 · Duperret et al., 2014 · Open in CIViC | civic |
| FGFR3 G697C | (oncogenic) | Oncogenic | D | Does Not Support Oncogenicity | 3 | accepted | EID10839Purified proteins of 26 FGFR3 kinase domain variants were used to directly compare the impact of different mutations on FGFR3 auto-phosphorylation. While known hotspot mutations K650E and N540K result… (full text at CIViC) PMID 26992226 · Patani et al., 2016 · Open in CIViC | civic |
ClinVar
Clinical significance (0)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
Data not yet available