Publication
New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (9)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 9
- cancerAstroblastoma, MN1-Alteredcivic_curation1.00
- cancerCentral Nervous System Neuroblastoma, FOXR2-Activatedcivic_curation1.00
- cancerCentral Nervous System Tumor with BCOR Internal Tandem Duplicationcivic_curation1.00
- geneBCORcivic_curation1.00
- geneBEND2civic_curation1.00
- geneFOXR2civic_curation1.00
- variantBCOR ITDcivic_curation1.00
- variantBEND2 Fusioncivic_curation1.00
- variantFOXR2 Rearrangementcivic_curation1.00
Curated evidence
Evidence citing this paper (4)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 26919435
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| BEND2 Fusion1 | ||||||||
| (diagnostic) | Astroblastoma, MN1-Altered | Diagnostic | B | Supports Positive | 4 | accepted | EID8510The authors studied tumors carrying a diagnosis of CNS primitive neuroectodermal tumors (PNETs). They identified four novel DNA methylation-defined brain tumor groups. One group, designated high-grade… (full text at CIViC) PMID 26919435 · Sturm et al., 2016 · Open in CIViC | civic |
| FOXR2 Rearrangement1 | ||||||||
| (diagnostic) | Central Nervous System Neuroblastoma, FOXR2-ActivatedALIAS | Diagnostic | B | Supports Positive | 4 | accepted | EID11527In the 2016 study by Sturm et al., the authors performed comprehensive molecular profiling, including DNA methylation arrays, transcriptomics, and genome-wide sequencing, on 323 institutionally diagno… (full text at CIViC) PMID 26919435 · Sturm et al., 2016 · Open in CIViC | civic |
| BCOR ITD2 | ||||||||
| (diagnostic) | Central Nervous System Tumor with BCOR Internal Tandem Duplication | Diagnostic | B | Supports Positive | 4 | accepted | EID10800The authors generated genome-wide DNA methylation profiles of 323 tumors with an institutional diagnosis of ‘primitive neuroectodermal tumors of the central nervous system (CNS-PNETs)’, which are hi… (full text at CIViC) PMID 26919435 · Sturm et al., 2016 · Open in CIViC | civic |
| (oncogenic) | Central Nervous System Tumor with BCOR Internal Tandem Duplication | Oncogenic | B | Supports Oncogenicity | 4 | accepted | EID1080410/323 studied high-grade primitive neuroectodermal tumors of the central nervous system (CNS-HGPNETs) clustered together based on their unique methylation profile. 10/10 of those tumors exhibited in… (full text at CIViC) PMID 26919435 · Sturm et al., 2016 · Open in CIViC | civic |