BEND2 Fusion

CI-VAR-00001422Explore in graph →CIViC 4995

Curated evidence

Evidence by cancer (2 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–2 of 2 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Astroblastoma, MN1-Altered2
MN1::CXXC5 Fusion OR MN1::BEND2 Fusion	(diagnostic)	Diagnostic	B	Supports Positive	3	submitted	EID12688 In a clinicopathologic and molecular series of astroblastoma (n = 8; biomarker MN1 rearrangement; primary endpoint diagnostic detection), MN1 break-apart FISH identified rearrangements in all informat… (full text at CIViC) PMID 28990708 · Hirose et al., 2018 · Open in CIViC	civic
MN1::BEND2 Fusion	(diagnostic)	Diagnostic	B	Supports Positive	4	accepted	EID8510 The authors studied tumors carrying a diagnosis of CNS primitive neuroectodermal tumors (PNETs). They identified four novel DNA methylation-defined brain tumor groups. One group, designated high-grade… (full text at CIViC) PMID 26919435 · Sturm et al., 2016 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.