FOXR2 Rearrangement

CI-VAR-00003962Explore in graph →CIViC 4575

Curated evidence

Evidence by cancer (3 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–3 of 3 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Central Nervous System Neuroblastoma, FOXR2-Activated3
FOXR2 Rearrangement	(diagnostic)	Diagnostic	B	Supports Positive	4	accepted	EID11527 In the 2016 study by Sturm et al., the authors performed comprehensive molecular profiling, including DNA methylation arrays, transcriptomics, and genome-wide sequencing, on 323 institutionally diagno… (full text at CIViC) PMID 26919435 · Sturm et al., 2016 · Open in CIViC	civic
FOXR2 Rearrangement	(diagnostic)	Diagnostic	B	Supports Positive	4	accepted	EID11528 DNA methylation profiling of 84 tumors initially diagnosed as CNS-PNET identified CNS neuroblastoma with FOXR2 activation (CNS NB-FOXR2) as a distinct molecular subgroup, presented in 24% (20/84) of c… (full text at CIViC) PMID 33536079 · Korshunov et al., 2021 · Open in CIViC

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.