Publication
Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
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Linked entities
Linked entities (8)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 8
- cancerMalignant Neoplasmcivic_curation1.00
- drugR3Mabcivic_curation1.00
- geneFGFR3civic_curation1.00
- variantFGFR3 G370Ccivic_curation1.00
- variantFGFR3 K650Ecivic_curation1.00
- variantFGFR3 Overexpressioncivic_curation1.00
- variantFGFR3 R248Ccivic_curation1.00
- variantFGFR3 Y373Ccivic_curation1.00
Curated evidence
Evidence citing this paper (14)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 19381019
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| FGFR3 R248C2 | ||||||||
| (oncogenic) | Bladder Carcinoma | Oncogenic | D | Supports Oncogenicity | 2 | submitted | EID10387FGFR3 R248C promoted FGF1 and IL-3 independent cell proliferation when transduced into Ba/F3 cells whereas Ba/F3 cells with wildtype FGFR3 were IL-3 independent, but FGF1 dependent. PMID 19381019 · Qing et al., 2009 · Open in CIViC | civic |
| R3Mab | Malignant NeoplasmALIAS | Predictive | D | Does Not Support Resistance | 3 | accepted | EID8321In this preclinical study, R3Mab (a monoclonal antibody specific to FGFR3) inhibited ligand-independent proliferation in Ba/F3 cells expressing common bladder carcinoma variant: FGFR3 R248C. Authors n… (full text at CIViC) PMID 19381019 · Qing et al., 2009 · Open in CIViC | civic |
| FGFR3 S249C2 | ||||||||
| (oncogenic) | Bladder Carcinoma | Oncogenic | D | Supports Oncogenicity | 4 | submitted | EID10386FGFR3 S249C promoted FGF1 and IL-3 independent cell proliferation when transduced into Ba/F3 cells, whereas Ba/F3 cells with wildtype FGFR3 were IL-3 independent, but FGF1 dependent. R3Mab (monclonal … (full text at CIViC) PMID 19381019 · Qing et al., 2009 · Open in CIViC | civic |
| R3Mab | Bladder Carcinoma | Predictive | D | Does Not Support Resistance | 3 | rejected | EID9088In a preclinical experiment, R3Mab (a monoclonal antibody specific to FGFR3) was tested against Ba/F3 and bladder carcinoma cell lines expressing FGFR3 wildtype and FGFR3 variants prevalent in bladder… (full text at CIViC) PMID 19381019 · Qing et al., 2009 · Open in CIViC | civic |
| FGFR3 G370C1 | ||||||||
| R3Mab | Malignant NeoplasmALIAS | Predictive | D | Does Not Support Resistance | 3 | accepted | EID10353Ba/F3 cells transfected with wild type FGFR3 or common bladder carcinoma variant FGFR3 G372C both resulted in IL-3 independence with FGF1 dependence for growth. Monoclonal antibody R3Mab treatment wit… (full text at CIViC) PMID 19381019 · Qing et al., 2009 · Open in CIViC | civic |
| FGFR3 K650E3 | ||||||||
| R3Mab | Malignant NeoplasmALIAS | Predictive | D | Does Not Support Resistance | 3 | accepted | EID10355Ba/F3 cells transfected with wildtype FGFR3 resulted in IL-3 independence with FGF1 dependence for growth, whereas cells transfected with common bladder carcinoma variant FGFR3 K652E resulted in IL-3 … (full text at CIViC) PMID 19381019 · Qing et al., 2009 · Open in CIViC | civic |
| (oncogenic) | Multiple Myeloma | Oncogenic | D | Supports Oncogenicity | 1 | submitted | EID10383Xenografts of multiple myeloma cell line OPM2 (FGFR3 K650E) into nude mice resulted in tumor growth. PMID 19381019 · Qing et al., 2009 · Open in CIViC | civic |
| R3Mab | Multiple Myeloma | Predictive | D | Supports Sensitivity Response | 4 | submitted | EID10365In culture, monoclonal antibody R3Mab treatment inhibited the growth of multiple myeloma cell line UTMC-2 which has wild type FGFR3 but did not affect proliferation of multiple myeloma cell line KMS11… (full text at CIViC) PMID 19381019 · Qing et al., 2009 · Open in CIViC | civic |
| FGFR3 Overexpression3 | ||||||||
| R3Mab | Malignant NeoplasmALIAS | Predictive | D | Supports Sensitivity Response | 3 | accepted | EID10352Pro-B Ba/F3 cells transfected with wild type FGFR3 resulted in Il-3 independence with FGF1 dependence for growth. Monoclonal antibody R3Mab treatment in addition to FGF1 resulted in suppression of pr… (full text at CIViC) PMID 19381019 · Qing et al., 2009 · Open in CIViC | civic |
| 〃 | Multiple Myeloma | Predictive | D | Supports Sensitivity Response | 4 | rejected | EID10363Pro-B Ba/F3 cells transfected with wild type FGFR3 resulted in Il-3 independence with FGF1 dependence for growth. Monoclonal antibody R3Mab treatment in addition to FGF1 resulted in suppression of pro… (full text at CIViC) PMID 19381019 · Qing et al., 2009 · Open in CIViC | civic |
| 〃 | Multiple Myeloma | Predictive | D | Supports Sensitivity Response | 4 | submitted | EID10364Pro-B Ba/F3 cells transfected with wild type FGFR3 resulted in Il-3 independence with FGF1 dependence for growth. Monoclonal antibody R3Mab treatment in addition to FGF1 resulted in suppression of pro… (full text at CIViC) PMID 19381019 · Qing et al., 2009 · Open in CIViC | civic |
| FGFR3 Y373C3 | ||||||||
| R3Mab | Malignant NeoplasmALIAS | Predictive | D | Does Not Support Resistance | 3 | accepted | EID10354Pro-B Ba/F3 cells transfected with wild type FGFR3 resulted in IL-3 independence with FGF1 dependence for growth. Cell transfected FGFR3 with mutation Y375C also resulted in IL-3 independence and FGF1… (full text at CIViC) PMID 19381019 · Qing et al., 2009 · Open in CIViC | civic |
| (oncogenic) | Multiple Myeloma | Oncogenic | D | Supports Oncogenicity | 2 | submitted | EID10385Ba/F3 cells transfected with wild type FGFR3 or common bladder carcinoma variant FGFR3 Y375C both resulted in IL-3 independence with FGF1 dependence for growth. However, tumors grew when multiple myel… (full text at CIViC) PMID 19381019 · Qing et al., 2009 · Open in CIViC | civic |
| R3Mab | Multiple Myeloma | Predictive | D | Supports Sensitivity Response | 4 | submitted | EID10366In culture, monoclonal antibody R3Mab treatment inhibited the growth of multiple myeloma cell line UTMC-2 which has wild type FGFR3 but did not affect proliferation of multiple myeloma cell line KMS11… (full text at CIViC) PMID 19381019 · Qing et al., 2009 · Open in CIViC | civic |