FGFR3 Overexpression

CI-VAR-00003134Explore in graph →CIViC 325

Curated evidence

Evidence by cancer (5 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–5 of 5 evidence items across 3 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Bladder Carcinoma1
FGFR3 Overexpression	Dovitinib + PD173074 + Tyrosine Kinase Inhibitor SU5402Substitutes	Predictive	D	Supports Sensitivity Response	3	accepted	EID803 The effects of FGFR inhibitors (PD173074, TKI-258 and SU5402) in bladder carcinoma cell lines were related to FGFR3 (and/or FGFR1) expression. PMID 21119661 · Lamont et al., 2011 · Open in CIViC	civic
Malignant Neoplasm1
FGFR3 Overexpression	R3Mab	Predictive	D	Supports Sensitivity Response	3	accepted	EID10352 Pro-B Ba/F3 cells transfected with wild type FGFR3 resulted in Il-3 independence with FGF1 dependence for growth. Monoclonal antibody R3Mab treatment in addition to FGF1 resulted in suppression of pr…

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.

Multiple Myeloma3
FGFR3 Overexpression	Dovitinib	Predictive	D	Does Not Support Sensitivity Response	2	submitted	EID12294 Multiple myeloma (MM) is a neoplastic disorder of clonal B cells characterised by uncontrolled and aberrant proliferation of plasma cells within bone marrow, monoclonal protein in the blood or urine, … (full text at CIViC) PMID 25402977 · Scheid et al., 2015 · Open in CIViC	civic
FGFR3 Overexpression	R3Mab	Predictive	D	Supports Sensitivity Response	4	rejected	EID10363 Pro-B Ba/F3 cells transfected with wild type FGFR3 resulted in Il-3 independence with FGF1 dependence for growth. Monoclonal antibody R3Mab treatment in addition to FGF1 resulted in suppression of pro… (full text at CIViC) PMID 19381019 · Qing et al., 2009 · Open in CIViC	civic
FGFR3 Overexpression	R3Mab	Predictive	D	Supports Sensitivity Response	4	submitted	EID10364 Pro-B Ba/F3 cells transfected with wild type FGFR3 resulted in Il-3 independence with FGF1 dependence for growth. Monoclonal antibody R3Mab treatment in addition to FGF1 resulted in suppression of pro… (full text at CIViC) PMID 19381019 · Qing et al., 2009 · Open in CIViC	civic