Publication

Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias.

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N Engl J Med2006PMID 16775234stubpubmedPublished

Abstract

Abstract (excerpt)

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Linked entities

Linked entities (27)

How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.

Validated 27

cancerAcute Lymphoblastic Leukemiacivic_curation1.00
cancerChronic Myeloid Leukemia, BCR-ABL1 Positivecivic_curation1.00
drugDasatinibcivic_curation1.00
drugImatinibcivic_curation1.00
geneABL1civic_curation1.00
variantABL1 D363Gcivic_curation1.00
variantABL1 E255Kcivic_curation1.00
variantABL1 E255Vcivic_curation1.00
variantABL1 E355Gcivic_curation1.00
variantABL1 E450Qcivic_curation1.00
variantABL1 E98Gcivic_curation1.00
variantABL1 F359Ccivic_curation1.00
variantABL1 F359Icivic_curation1.00
variantABL1 F359Vcivic_curation1.00
variantABL1 Fusioncivic_curation1.00
variantABL1 H396Rcivic_curation1.00
variantABL1 L364Icivic_curation1.00
variantABL1 L387Mcivic_curation1.00
variantABL1 M244Vcivic_curation1.00
variantABL1 M351Tcivic_curation1.00
variantABL1 M388Lcivic_curation1.00
variantABL1 N146Scivic_curation1.00
variantABL1 S438Ccivic_curation1.00
variantABL1 T315Icivic_curation1.00
variantABL1 V289Icivic_curation1.00
variantABL1 V379Icivic_curation1.00
variantABL1 Y253Hcivic_curation1.00

Curated evidence

Evidence citing this paper (42)

civicCuratedShowing 1–42 of 42 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
ABL1 Fusion2
Dasatinib	Acute Lymphoblastic Leukemia	Predictive	C	Supports Sensitivity Response	3	accepted	EID4436 Prior to dasatinib treatment, one imatinib-resistant patient with acute lymphoblastic leukemia had the BCR-ABL1 fusion with no secondary variants in at least ten bacterial clones generated using perip… (full text at CIViC) PMID 16775234 · Talpaz et al., 2006 · Open in CIViC	civic
〃	Chronic Myeloid Leukemia, BCR-ABL1 PositiveALIAS	Predictive	C	Supports Sensitivity Response	4	accepted	EID4706 Prior to dasatanib treatment, fifteen imatinib-resistant patients with chronic myeloid leukemia in various phases had the BCR-ABL1 fusion with no secondary variants in at least ten clones generated us… (full text at CIViC) PMID 16775234 · Talpaz et al., 2006 · Open in CIViC	civic
ABL1 E255K + ABL1 Fusion2
Dasatinib	Acute Lymphoblastic Leukemia	Predictive	C	Supports Resistance	3	accepted	EID4718 Prior to dasatinib treatment, one imatinib-resistant patient with acute lymphoblastic leukemia had the BCR-ABL1 fusion with the E255K secondary variant in 3/12 bacterial clones generated using periphe… (full text at CIViC) PMID 16775234 · Talpaz et al., 2006 · Open in CIViC	civic
〃	Chronic Myeloid Leukemia, BCR-ABL1 PositiveALIAS	Predictive	C	Does Not Support Resistance	3	accepted	EID4353 Prior to dasatinib treatment, one imatinib-resistant patient with chronic myeloid leukemia in chronic phase had the BCR-ABL1 fusion with the E255K secondary variant in 12/12 bacterial clones generated… (full text at CIViC) PMID 16775234 · Talpaz et al., 2006 · Open in CIViC	civic
ABL1 M244V + ABL1 Fusion3
Dasatinib	Acute Lymphoblastic Leukemia	Predictive	C	Supports Resistance	3	submitted	EID4387 In a retrospective study of 84 imatinib-resistant or -intolerant Philadelphia chromosome BCR-ABL1 fusion positive (Ph+) chronic myeloid leukemia (in accelerated-phase or with blast crisis) or Ph+ acut… (full text at CIViC) PMID 16775234 · Talpaz et al., 2006 · Open in CIViC	civic
〃	Chronic Myeloid Leukemia, BCR-ABL1 PositiveALIAS	Predictive	C	Does Not Support Resistance	2	accepted	EID4305 Prior to dasatinib treatment, one imatinib-resistant patient with chronic myeloid leukemia in chronic phase had the BCR-ABL1 fusion with the M244V secondary variant in 12/12 bacterial clones generated… (full text at CIViC) PMID 16775234 · Talpaz et al., 2006 · Open in CIViC	civic
Imatinib	Chronic Myeloid Leukemia, BCR-ABL1 PositiveALIAS	Predictive	C	Supports Resistance	1	accepted	EID7825 One chronic myeloid leukemia patient in chronic phase had no response to imatinib. Bacterial clones generated using peripheral blood RNA later revealed the BCR-ABL1 fusion with the M244V secondary var… (full text at CIViC) PMID 16775234 · Talpaz et al., 2006 · Open in CIViC	civic
ABL1 Y253H + ABL1 Fusion3
Dasatinib	Acute Lymphoblastic Leukemia	Predictive	C	Does Not Support Resistance	3	accepted	EID7947 Prior to dasatinib treatment, one imatinib-resistant patient with acute lymphoblastic leukemia had the BCR-ABL1 fusion with Y253H and Y253H/Q252R variants in 9/10 and 1/10 clones, respectively. Clones… (full text at CIViC) PMID 16775234 · Talpaz et al., 2006 · Open in CIViC	civic
〃	Chronic Myeloid Leukemia, BCR-ABL1 PositiveALIAS	Predictive	C	Does Not Support Resistance	4	accepted	EID4336 Prior to dasatinib treatment, one imatinib-resistant patient with chronic myeloid leukemia in chronic phase had the BCR-ABL1 fusion with the Y253H secondary variant in 11/11 bacterial clones generated… (full text at CIViC) PMID 16775234 · Talpaz et al., 2006 · Open in CIViC	civic
〃	Chronic Myeloid Leukemia, BCR-ABL1 PositiveALIAS	Predictive	C	Does Not Support Resistance	3	accepted	EID7949 Prior to dasatinib treatment, one imatinib-resistant patient with chronic myeloid leukemia in chronic phase had the BCR-ABL1 fusion with Y253H, M388L, and M388L/M244V variants in 4/10, 5/10, and 1/10 … (full text at CIViC) PMID 16775234 · Talpaz et al., 2006 · Open in CIViC	civic
ABL1 BCR::ABL E255V1
Imatinib	Chronic Myeloid Leukemia, BCR-ABL1 PositiveALIAS	Predictive	C	Supports Resistance	3	rejected	EID7821 One chronic myeloid leukemia patient in chronic phase had a minimal best cytogenetic response to imatinib but became resistant. Bacterial clones generated using peripheral blood RNA later showed the B… (full text at CIViC) PMID 16775234 · Talpaz et al., 2006 · Open in CIViC	civic
ABL1 BCR::ABL F486S1
Dasatinib	Chronic Myeloid Leukemia, BCR-ABL1 PositiveALIAS	Predictive	C	Supports Sensitivity Response	—	rejected	EID4572 In a retrospective study of 84 imatinib-resistant or -intolerant Philadelphia chromosome BCR-ABL1 fusion positive (Ph+) chronic myeloid leukemia (in accelerated-phase or with blast crisis) or Ph+ acut… (full text at CIViC) PMID 16775234 · Talpaz et al., 2006 · Open in CIViC	civic
ABL1 BCR::ABL N49S1
Dasatinib	Chronic Myeloid Leukemia, BCR-ABL1 PositiveALIAS	Predictive	C	Does Not Support Resistance	3	rejected	EID7944 Prior to dasatinib treatment, one imatinib-resistant patient with chronic myeloid leukemia in accelerated phase had the BCR-ABL1 fusion with G250E/E138G/I242T/K271R/V338M, G250E/E138G/I242T/K271R, G25… (full text at CIViC) PMID 16775234 · Talpaz et al., 2006 · Open in CIViC	civic
ABL1 BCR::ABL V186A1
Imatinib	Chronic Myeloid Leukemia, BCR-ABL1 PositiveALIAS	Predictive	C	Supports Resistance	2	rejected	EID7828 One chronic myeloid leukemia patient in chronic phase with the BCR-ABL1 fusion and the V186A secondary variant in 2/12 clones had no response to imatinib before becoming completely resistant. PMID 16775234 · Talpaz et al., 2006 · Open in CIViC	civic
ABL1 BCR::ABL Y253H1
Imatinib	Chronic Myeloid Leukemia, BCR-ABL1 PositiveALIAS	Predictive	C	Supports Resistance	2	rejected	EID7829 One chronic myeloid leukemia patient in chronic phase with the BCR-ABL1 fusion and the Y253H secondary variant in 11/11 clones had complete cytogenetic best cytogenetic response to imatinib before bec… (full text at CIViC) PMID 16775234 · Talpaz et al., 2006 · Open in CIViC	civic
ABL1 D363G + ABL1 Fusion2
Dasatinib	Chronic Myeloid Leukemia, BCR-ABL1 PositiveALIAS	Predictive	C	Supports Sensitivity Response	3	accepted	EID4692 Prior to dasatinib treatment, one imatinib-resistant patient with chronic myeloid leukemia in chronic phase had the BCR-ABL1 fusion with the D363G secondary variant in 2/10 bacterial clones generated … (full text at CIViC) PMID 16775234 · Talpaz et al., 2006 · Open in CIViC	civic
Imatinib	Chronic Myeloid Leukemia, BCR-ABL1 PositiveALIAS	Predictive	C	Supports Resistance	1	accepted	EID7820 One chronic myeloid leukemia patient in chronic phase had a partial best cytogenetic response to imatinib but became resistant. Bacterial clones generated using peripheral blood RNA revealed the BCR-A… (full text at CIViC) PMID 16775234 · Talpaz et al., 2006 · Open in CIViC	civic
ABL1 E255V + ABL1 Fusion1
Dasatinib	Chronic Myeloid Leukemia, BCR-ABL1 PositiveALIAS	Predictive	C	Does Not Support Resistance	3	accepted	EID4448 Three chronic myeloid leukemia patients had the BCR-ABL1 fusion with the E255V secondary variant in one or more bacterial clones generated using peripheral blood RNA. They had no best cytogenetic resp… (full text at CIViC) PMID 16775234 · Talpaz et al., 2006 · Open in CIViC	civic
ABL1 E355G + ABL1 Fusion1
Dasatinib	Chronic Myeloid Leukemia, BCR-ABL1 PositiveALIAS	Predictive	C	Does Not Support Resistance	3	accepted	EID4404 Prior to dasatinib treatment, three imatinib-resistant patients with chronic myeloid leukemia had the BCR-ABL1 fusion with the E355G secondary variant in one or more bacterial clones. Clones were gene… (full text at CIViC) PMID 16775234 · Talpaz et al., 2006 · Open in CIViC	civic
ABL1 E450Q + ABL1 Fusion1
Dasatinib	Chronic Myeloid Leukemia, BCR-ABL1 PositiveALIAS	Predictive	C	Does Not Support Resistance	4	accepted	EID7942 Prior to dasatinib treatment, one imatinib-resistant patient with chronic myeloid leukemia in chronic phase had the BCR-ABL1 fusion with E450Q/M351T and E450Q variants in 1/10 and 9/10 clones, respect… (full text at CIViC) PMID 16775234 · Talpaz et al., 2006 · Open in CIViC	civic
ABL1 E98G + ABL1 Fusion2
Dasatinib	Chronic Myeloid Leukemia, BCR-ABL1 PositiveALIAS	Predictive	C	Does Not Support Resistance	3	accepted	EID4711 Prior to dasatinib treatment, one imatinib-resistant patient with chronic myeloid leukemia in chronic phase had the BCR-ABL1 fusion with the E98G secondary variant in 11/11 bacterial clones generated … (full text at CIViC) PMID 16775234 · Talpaz et al., 2006 · Open in CIViC	civic
Imatinib	Chronic Myeloid Leukemia, BCR-ABL1 PositiveALIAS	Predictive	C	Supports Resistance	1	accepted	EID7822 One chronic myeloid leukemia patient in chronic phase had a complete best cytogenetic response to imatinib but became resistant. Bacterial clones generated using peripheral blood RNA later revealed th… (full text at CIViC) PMID 16775234 · Talpaz et al., 2006 · Open in CIViC	civic
ABL1 F359C + ABL1 Fusion1
Dasatinib	Chronic Myeloid Leukemia, BCR-ABL1 PositiveALIAS	Predictive	C	Does Not Support Resistance	4	accepted	EID4483 Prior to dasatinib treatment, one imatinib-resistant patient with chronic myeloid leukemia in chronic phase had the BCR-ABL1 fusion with G250E and F359C variants in 3/10 and 5/10 clones, respectively.… (full text at CIViC) PMID 16775234 · Talpaz et al., 2006 · Open in CIViC	civic
ABL1 F359I + ABL1 Fusion1
Dasatinib	Chronic Myeloid Leukemia, BCR-ABL1 PositiveALIAS	Predictive	C	Does Not Support Resistance	3	accepted	EID4533 Prior to dasatinib treatment, one imatinib-resistant patient with chronic myeloid leukemia in chronic phase had the BCR-ABL1 fusion with the F359I secondary variant in 9/9 bacterial clones generated u… (full text at CIViC) PMID 16775234 · Talpaz et al., 2006 · Open in CIViC	civic
ABL1 F359V + ABL1 Fusion2
Dasatinib	Chronic Myeloid Leukemia, BCR-ABL1 PositiveALIAS	Predictive	C	Supports Resistance	2	accepted	EID3820 Prior to dasatinib treatment, two imatinib-resistant patients with chronic myeloid leukemia (CML) in chronic phase had the BCR-ABL1 fusion, one with the T315I, F359V, M244V, and G250E variants in 2/10… (full text at CIViC) PMID 16775234 · Talpaz et al., 2006 · Open in CIViC	civic
〃	Chronic Myeloid Leukemia, BCR-ABL1 PositiveALIAS	Predictive	C	Does Not Support Resistance	1	accepted	EID8002 Prior to dasatinib treatment, one imatinib-resistant patients with chronic myeloid leukemia (CML) in myeloid blast crisis had the BCR-ABL1 fusion with F359V, F359V/Q252R, and L273M secondary variants … (full text at CIViC) PMID 16775234 · Talpaz et al., 2006 · Open in CIViC	civic
ABL1 G250E + ABL1 Fusion1
Dasatinib	Chronic Myeloid Leukemia, BCR-ABL1 PositiveALIAS	Predictive	C	Does Not Support Resistance	3	submitted	EID4319 Prior to dasatinib treatment, two imatinib-resistant patients with chronic-phase chronic myeloid leukemia had the BCR-ABL1 fusion with G250E or G250E and G250E/F317L secondary variants in 10/10 or 9/1… (full text at CIViC) PMID 16775234 · Talpaz et al., 2006 · Open in CIViC	civic
ABL1 H396R + ABL1 Fusion2
Dasatinib	Chronic Myeloid Leukemia, BCR-ABL1 PositiveALIAS	Predictive	C	Supports Sensitivity Response	2	submitted	EID4415 In a retrospective study of 84 imatinib-resistant or -intolerant Philadelphia chromosome BCR-ABL1 fusion positive (Ph+) chronic myeloid leukemia (in accelerated-phase or with blast crisis) or Ph+ acut… (full text at CIViC) PMID 16775234 · Talpaz et al., 2006 · Open in CIViC	civic
〃	Chronic Myeloid Leukemia, BCR-ABL1 PositiveALIAS	Predictive	C	Does Not Support Resistance	3	accepted	EID7823 Prior to dasatinib treatment, one imatinib-resistant patient with chronic myeloid leukemia in chronic phase had the BCR-ABL1 fusion with H396R and E355G variants in 9/11 and 1/11 clones, respectively.… (full text at CIViC) PMID 16775234 · Talpaz et al., 2006 · Open in CIViC	civic
ABL1 L364I + ABL1 Fusion2
Dasatinib	Chronic Myeloid Leukemia, BCR-ABL1 PositiveALIAS	Predictive	C	Does Not Support Resistance	3	accepted	EID4434 Prior to dasatinib treatment, one imatinib-resistant patient with chronic myeloid leukemia in chronic phase had the BCR-ABL1 fusion with the L364I secondary variant in 9/12 bacterial clones generated … (full text at CIViC) PMID 16775234 · Talpaz et al., 2006 · Open in CIViC	civic
Imatinib	Chronic Myeloid Leukemia, BCR-ABL1 PositiveALIAS	Predictive	C	Supports Resistance	1	accepted	EID7826 One chronic myeloid leukemia patient in chronic phase had no response to imatinib. Bacterial clones generated using peripheral blood RNA later showed the BCR-ABL1 fusion with the L364I secondary varia… (full text at CIViC) PMID 16775234 · Talpaz et al., 2006 · Open in CIViC	civic
ABL1 L364I + ABL1 M244V + ABL1 Fusion1
Dasatinib	Chronic Myeloid Leukemia, BCR-ABL1 PositiveALIAS	Predictive	C	Does Not Support Resistance	3	accepted	EID7943 Prior to dasatinib treatment, one imatinib-resistant patient with chronic myeloid leukemia in myeloid blast crisis had the BCR-ABL1 fusion with M244V/L364I, M244V/L364I/N53S, M244V/L364I/M458T, L364I/… (full text at CIViC) PMID 16775234 · Talpaz et al., 2006 · Open in CIViC	civic
ABL1 L384M + ABL1 Fusion1
Imatinib	Chronic Myeloid Leukemia, BCR-ABL1 PositiveALIAS	Predictive	C	Supports Resistance	2	submitted	EID7824 One chronic myeloid leukemia patient in chronic phase with the BCR-ABL1 fusion and the F486S secondary variant in 2/11 clones had partial best cytogenetic response to imatinib before becoming complete… (full text at CIViC) PMID 16775234 · Talpaz et al., 2006 · Open in CIViC	civic
ABL1 L387M + ABL1 Fusion1
Dasatinib	Chronic Myeloid Leukemia, BCR-ABL1 PositiveALIAS	Predictive	C	Does Not Support Resistance	3	accepted	EID4407 Prior to dasatinib treatment, one imatinib-resistant patient with chronic myeloid leukemia in chronic phase had the BCR-ABL1 fusion with L387M, L387M/F192L, and E450G variants in 7/10, 2/10, and 1/10 … (full text at CIViC) PMID 16775234 · Talpaz et al., 2006 · Open in CIViC	civic
ABL1 M351T + ABL1 Fusion2
Dasatinib	Chronic Myeloid Leukemia, BCR-ABL1 PositiveALIAS	Predictive	C	Does Not Support Resistance	3	accepted	EID4398 Prior to dasatinib treatment, four imatinib-resistant patients with chronic myeloid leukemia in chronic phase had the BCR-ABL1 fusion with the M351T and M351S; M351T; M351T; and M351T secondary varian… (full text at CIViC) PMID 16775234 · Talpaz et al., 2006 · Open in CIViC	civic
Imatinib	Chronic Myeloid Leukemia, BCR-ABL1 PositiveALIAS	Predictive	C	Supports Resistance	2	submitted	EID7827 Three patients with chronic myeloid leukemia in chronic phase with the BCR-ABL1 fusion and the M351T secondary variant in 4/10, 10/10, and 11/11 clones had none, partial, and partial best cytogenetic … (full text at CIViC) PMID 16775234 · Talpaz et al., 2006 · Open in CIViC	civic
ABL1 M388L + ABL1 Fusion1
Dasatinib	Chronic Myeloid Leukemia, BCR-ABL1 PositiveALIAS	Predictive	C	Does Not Support Resistance	3	accepted	EID7950 Prior to dasatinib treatment, one imatinib-resistant patient with chronic myeloid leukemia in chronic phase had the BCR-ABL1 fusion with Y253H, M388L, and M388L/M244V variants in 4/10, 5/10, and 1/10 … (full text at CIViC) PMID 16775234 · Talpaz et al., 2006 · Open in CIViC	civic
ABL1 N146S + ABL1 Fusion1
Dasatinib	Chronic Myeloid Leukemia, BCR-ABL1 PositiveALIAS	Predictive	C	Does Not Support Resistance	3	accepted	EID7945 Prior to dasatinib treatment, one imatinib-resistant patient with chronic myeloid leukemia in accelerated phase had the BCR-ABL1 fusion with G250E/E138G/I242T/K271R/V338M, G250E/E138G/I242T/K271R, G25… (full text at CIViC) PMID 16775234 · Talpaz et al., 2006 · Open in CIViC	civic
ABL1 S438C + ABL1 Fusion1
Dasatinib	Chronic Myeloid Leukemia, BCR-ABL1 PositiveALIAS	Predictive	C	Supports Resistance	3	accepted	EID7948 Prior to dasatinib treatment, one imatinib-resistant patient with chronic myeloid leukemia in chronic phase had the BCR-ABL1 fusion with the S438C, K466E, and K466R secondary variants in 6/10, 1/10. a… (full text at CIViC) PMID 16775234 · Talpaz et al., 2006 · Open in CIViC	civic
ABL1 T315I + ABL1 Fusion1
Dasatinib	Chronic Myeloid Leukemia, BCR-ABL1 PositiveALIAS	Predictive	C	Supports Resistance	3	accepted	EID4373 Prior to dasatinib treatment, two imatinib-resistant patients with chronic myeloid leukemia in accelerated phase had the BCR-ABL1 fusion with the T315I secondary variant in 8/10 and 10/10 bacterial cl… (full text at CIViC) PMID 16775234 · Talpaz et al., 2006 · Open in CIViC	civic
ABL1 V289I + ABL1 Fusion1
Dasatinib	Chronic Myeloid Leukemia, BCR-ABL1 PositiveALIAS	Predictive	C	Does Not Support Resistance	3	accepted	EID7946 Prior to dasatinib treatment, one imatinib-resistant patient with chronic myeloid leukemia in chronic phase had the BCR-ABL1 fusion with V289I, V289I/M388L, and G250E variants in 8/11, 1/11, and 1/11 … (full text at CIViC) PMID 16775234 · Talpaz et al., 2006 · Open in CIViC	civic
ABL1 V379I + ABL1 Fusion1
Dasatinib	Chronic Myeloid Leukemia, BCR-ABL1 PositiveALIAS	Predictive	C	Does Not Support Resistance	3	accepted	EID4702 Prior to dasatinib treatment, one imatinib-resistant patient with chronic myeloid leukemia in accelerated phase had the BCR-ABL1 fusion with E279K, V379I, and V379I/F317L/M351T variants in 3/11, 5/11,… (full text at CIViC) PMID 16775234 · Talpaz et al., 2006 · Open in CIViC	civic