XIRP2

xin actin binding repeat containing 2

Identifier: CI-GENE-00038963
Entity page: /gene/XIRP2 ↗
Edges: 27

Neighbours: 22 cancers5 variants
Drawn: 27 of 27 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
XIRP2 has variant …HAS_VARIANTderived5 of 5
→ has variant	NM_152381.6(XIRP2):c.*1470G>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_152381.6(XIRP2):c.4898T>G (p.Val1633Gly)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed

XIRP2 altered in cohorts of …ALTERED_INderived22 of 22show fewer
→ altered in cohorts of	Skin Squamous Cell Carcinoma 28 / 39 cases (72 %) · ssm · cscc_hgsc_bcm_2014	—	—	Skin Squamous Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Skin Basal Cell Carcinoma 74 / 126 cases (59 %) · ssm · bcc_unige_2016	—	—	Skin Basal Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Cutaneous Melanoma 151 / 469 cases (32 %) · ssm · skcm_tcga_gdc · largest of 7 cohorts	—	—	Cutaneous Melanoma	7	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Adenocarcinoma 150 / 566 cases (27 %) · ssm · luad_tcga_pan_can_atlas_2018 · largest of 8 cohorts	—	—	Lung Adenocarcinoma	8	Observed	cbioportal	graph →
→ altered in cohorts of	Melanoma 37 / 144 cases (26 %) · ssm · mel_dfci_2019 · largest of 2 cohorts	—	—	Melanoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Non-Small Cell Carcinoma 268 / 1,144 cases (23 %) · ssm · nsclc_tcga_broad_2016 · largest of 2 cohorts	—	—	Lung Non-Small Cell Carcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Squamous Cell Carcinoma 95 / 484 cases (20 %) · ssm · lusc_tcga_gdc · largest of 5 cohorts	—	—	Lung Squamous Cell Carcinoma	5	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Small Cell Carcinoma 23 / 120 cases (19 %) · ssm · sclc_ucologne_2015	—	—	Lung Small Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Endometrial Carcinoma 81 / 517 cases (16 %) · ssm · ucec_tcga_pan_can_atlas_2018 · largest of 4 cohorts	—	—	Endometrial Carcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Renal Cell Carcinoma 24 / 158 cases (15 %) · ssm · rcc_iatlas_immotion150_2018	—	—	Renal Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Gastroesophageal Junction Adenocarcinoma 66 / 518 cases (13 %) · ssm · stes_tcga_pub	—	—	Gastroesophageal Junction Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Esophageal Adenocarcinoma 23 / 185 cases (12 %) · ssm · esca_tcga	—	—	Esophageal Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Endometrial Endometrioid Adenocarcinoma 30 / 247 cases (12 %) · ssm · uec_cptac_gdc	—	—	Endometrial Endometrioid Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Colon Adenocarcinoma 50 / 429 cases (12 %) · ssm · coad_tcga_gdc · largest of 2 cohorts	—	—	Colon Adenocarcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Gastric Adenocarcinoma 52 / 478 cases (11 %) · ssm · stad_tcga · largest of 4 cohorts	—	—	Gastric Adenocarcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Head and Neck Squamous Cell Carcinoma 52 / 515 cases (10 %) · ssm · hnsc_tcga_pan_can_atlas_2018 · largest of 4 cohorts	—	—	Head and Neck Squamous Cell Carcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Bladder Urothelial Carcinoma 40 / 474 cases (8.4 %) · ssm · blca_msk_tcga_2020 · largest of 5 cohorts	—	—	Bladder Urothelial Carcinoma	5	Observed	cbioportal	graph →
→ altered in cohorts of	Hepatocellular Carcinoma 41 / 494 cases (8.3 %) · ssm · hcc_clca_2024 · largest of 4 cohorts	—	—	Hepatocellular Carcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Colorectal Adenocarcinoma 70 / 1,015 cases (6.9 %) · ssm · crc_sysucc_2022 · largest of 2 cohorts	—	—	Colorectal Adenocarcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Clear Cell Renal Cell Carcinoma 28 / 451 cases (6.2 %) · ssm · kirc_tcga	—	—	Clear Cell Renal Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Diffuse Glioma 24 / 444 cases (5.4 %) · ssm · difg_glass_2019	—	—	Diffuse Glioma	1	Observed	cbioportal	graph →
→ altered in cohorts of	B-Cell Non-Hodgkin Lymphoma 40 / 755 cases (5.3 %) · ssm · mbn_mdacc_2013	—	—	B-Cell Non-Hodgkin Lymphoma	1	Observed	cbioportal	graph →

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