SPTA1

spectrin alpha, erythrocytic 1

Identifier: CI-GENE-00033671
Entity page: /gene/SPTA1 ↗
Edges: 29

Neighbours: 23 cancers6 variants
Drawn: 29 of 29 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
SPTA1 has variant …HAS_VARIANTderived6 of 6
→ has variant	NM_003126.4(SPTA1):c.3715-11T>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_003126.4(SPTA1):c.3997-42A>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed

SPTA1 altered in cohorts of …ALTERED_INderived23 of 23show fewer
→ altered in cohorts of	Lung Adenocarcinoma 400 / 573 cases (70 %) · ssm · TCGA-LUAD · largest of 11 cohorts	—	—	Lung Adenocarcinoma	11	Observed	gdc	graph →
→ altered in cohorts of	Skin Basal Cell Carcinoma 66 / 126 cases (52 %) · ssm · bcc_unige_2016	—	—	Skin Basal Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Endometrial Carcinoma 269 / 559 cases (48 %) · ssm · TCGA-UCEC · largest of 5 cohorts	—	—	Endometrial Carcinoma	5	Observed	gdc	graph →
→ altered in cohorts of	Skin Squamous Cell Carcinoma 37 / 83 cases (45 %) · ssm · cscc_ucsf_2021 · largest of 3 cohorts	—	—	Skin Squamous Cell Carcinoma	3	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Non-Small Cell Carcinoma 284 / 1,144 cases (25 %) · ssm · nsclc_tcga_broad_2016 · largest of 2 cohorts	—	—	Lung Non-Small Cell Carcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Cutaneous Melanoma 113 / 469 cases (24 %) · ssm · skcm_tcga_gdc · largest of 6 cohorts	—	—	Cutaneous Melanoma	6	Observed	cbioportal	graph →
→ altered in cohorts of	Melanoma 32 / 144 cases (22 %) · ssm · mel_dfci_2019 · largest of 2 cohorts	—	—	Melanoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Squamous Cell Carcinoma 97 / 484 cases (20 %) · ssm · lusc_tcga_pan_can_atlas_2018 · largest of 4 cohorts	—	—	Lung Squamous Cell Carcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Thymoma 24 / 124 cases (19 %) · ssm · TCGA-THYM	—	—	Thymoma	1	Observed	gdc	graph →
→ altered in cohorts of	Lung Small Cell Carcinoma 23 / 120 cases (19 %) · ssm · sclc_ucologne_2015	—	—	Lung Small Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Gastroesophageal Junction Adenocarcinoma 86 / 518 cases (17 %) · ssm · stes_tcga_pub	—	—	Gastroesophageal Junction Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Gastric Adenocarcinoma 69 / 478 cases (14 %) · ssm · stad_tcga · largest of 4 cohorts	—	—	Gastric Adenocarcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Esophageal Adenocarcinoma 25 / 185 cases (14 %) · ssm · esca_tcga · largest of 3 cohorts	—	—	Esophageal Adenocarcinoma	3	Observed	cbioportal	graph →
→ altered in cohorts of	Endometrial Endometrioid Adenocarcinoma 31 / 247 cases (13 %) · ssm · uec_cptac_gdc	—	—	Endometrial Endometrioid Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Colon Adenocarcinoma 50 / 429 cases (12 %) · ssm · coad_tcga_gdc · largest of 2 cohorts	—	—	Colon Adenocarcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Hepatocellular Carcinoma 40 / 494 cases (8.1 %) · ssm · hcc_clca_2024 · largest of 5 cohorts	—	—	Hepatocellular Carcinoma	5	Observed	cbioportal	graph →
→ altered in cohorts of	Bladder Urothelial Carcinoma 35 / 474 cases (7.4 %) · ssm · blca_msk_tcga_2020 · largest of 5 cohorts	—	—	Bladder Urothelial Carcinoma	5	Observed	cbioportal	graph →
→ altered in cohorts of	Colorectal Adenocarcinoma 64 / 1,015 cases (6.3 %) · ssm · crc_sysucc_2022 · largest of 3 cohorts	—	—	Colorectal Adenocarcinoma	3	Observed	cbioportal	graph →
→ altered in cohorts of	Diffuse Glioma 39 / 629 cases (6.2 %) · ssm · difg_glass · largest of 6 cohorts	—	—	Diffuse Glioma	6	Observed	cbioportal	graph →
→ altered in cohorts of	Head and Neck Squamous Cell Carcinoma 31 / 515 cases (6.0 %) · ssm · hnsc_tcga_pan_can_atlas_2018 · largest of 3 cohorts	—	—	Head and Neck Squamous Cell Carcinoma	3	Observed	cbioportal	graph →
→ altered in cohorts of	Cholangiocarcinoma 24 / 417 cases (5.8 %) · ssm · chol_icgc_2017	—	—	Cholangiocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Prostate Adenocarcinoma 26 / 499 cases (5.2 %) · ssm · prad_tcga	—	—	Prostate Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Invasive Breast Carcinoma 54 / 1,066 cases (5.1 %) · ssm · brca_tcga_pan_can_atlas_2018 · largest of 2 cohorts	—	—	Invasive Breast Carcinoma	2	Observed	cbioportal	graph →

SPTA1 altered in cohorts of …ALTERED_INderived23 of 23show fewer

→ altered in cohorts of

Lung Adenocarcinoma

400 / 573 cases (70 %) · ssm · TCGA-LUAD · largest of 11 cohorts

—

Lung Adenocarcinoma

Observed

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