RYR3

ryanodine receptor 3

Identifier: CI-GENE-00029702
Entity page: /gene/RYR3 ↗
Edges: 41

Neighbours: 23 cancers15 variants
Drawn: 38 of 38 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
RYR3 has variant …HAS_VARIANTderived15 of 18show all (up to 200)
→ has variant	NM_001036.6(RYR3):c.10921A>G (p.Met3641Val)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001036.6(RYR3):c.11072+8C>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0

RYR3 altered in cohorts of …ALTERED_INderived23 of 23show fewer
→ altered in cohorts of	Skin Squamous Cell Carcinoma 25 / 39 cases (64 %) · ssm · cscc_hgsc_bcm_2014 · largest of 2 cohorts	—	—	Skin Squamous Cell Carcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Skin Basal Cell Carcinoma 70 / 126 cases (56 %) · ssm · bcc_unige_2016	—	—	Skin Basal Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Squamous Cell Carcinoma 99 / 484 cases (20 %) · ssm · lusc_tcga_pan_can_atlas_2018 · largest of 5 cohorts	—	—	Lung Squamous Cell Carcinoma	5	Observed	cbioportal	graph →
→ altered in cohorts of	Endometrial Carcinoma 102 / 517 cases (20 %) · ssm · ucec_tcga_pan_can_atlas_2018 · largest of 4 cohorts	—	—	Endometrial Carcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Renal Cell Carcinoma 31 / 158 cases (20 %) · ssm · rcc_iatlas_immotion150_2018	—	—	Renal Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Non-Small Cell Carcinoma 217 / 1,144 cases (19 %) · ssm · nsclc_tcga_broad_2016 · largest of 2 cohorts	—	—	Lung Non-Small Cell Carcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Adenocarcinoma 106 / 566 cases (19 %) · ssm · luad_tcga_pan_can_atlas_2018 · largest of 6 cohorts	—	—	Lung Adenocarcinoma	6	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Small Cell Carcinoma 22 / 120 cases (18 %) · ssm · sclc_ucologne_2015	—	—	Lung Small Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Cutaneous Melanoma 85 / 469 cases (18 %) · ssm · skcm_tcga_gdc · largest of 6 cohorts	—	—	Cutaneous Melanoma	6	Observed	cbioportal	graph →
→ altered in cohorts of	Melanoma 26 / 144 cases (18 %) · ssm · mel_dfci_2019 · largest of 2 cohorts	—	—	Melanoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Colon Adenocarcinoma 71 / 429 cases (17 %) · ssm · coad_tcga_gdc · largest of 2 cohorts	—	—	Colon Adenocarcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Endometrial Endometrioid Adenocarcinoma 40 / 247 cases (16 %) · ssm · uec_cptac_gdc	—	—	Endometrial Endometrioid Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Gastroesophageal Junction Adenocarcinoma 74 / 518 cases (14 %) · ssm · stes_tcga_pub	—	—	Gastroesophageal Junction Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Gastric Adenocarcinoma 61 / 478 cases (13 %) · ssm · stad_tcga · largest of 4 cohorts	—	—	Gastric Adenocarcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Esophageal Adenocarcinoma 23 / 185 cases (12 %) · ssm · esca_tcga	—	—	Esophageal Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Hepatocellular Carcinoma 47 / 494 cases (9.5 %) · ssm · hcc_clca_2024 · largest of 4 cohorts	—	—	Hepatocellular Carcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Colorectal Adenocarcinoma 83 / 1,015 cases (8.2 %) · ssm · crc_sysucc_2022 · largest of 5 cohorts	—	—	Colorectal Adenocarcinoma	5	Observed	cbioportal	graph →
→ altered in cohorts of	Bladder Urothelial Carcinoma 34 / 474 cases (7.2 %) · ssm · blca_msk_tcga_2020 · largest of 5 cohorts	—	—	Bladder Urothelial Carcinoma	5	Observed	cbioportal	graph →
→ altered in cohorts of	B-Cell Non-Hodgkin Lymphoma 54 / 755 cases (7.2 %) · ssm · mbn_mdacc_2013	—	—	B-Cell Non-Hodgkin Lymphoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Head and Neck Squamous Cell Carcinoma 35 / 515 cases (6.8 %) · ssm · hnsc_tcga_pan_can_atlas_2018 · largest of 4 cohorts	—	—	Head and Neck Squamous Cell Carcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Prostate Adenocarcinoma 26 / 444 cases (5.9 %) · ssm · prad_su2c_2019	—	—	Prostate Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Invasive Breast Carcinoma 20 / 379 cases (5.3 %) · ssm · brca_mbcproject_2022 · largest of 2 cohorts	—	—	Invasive Breast Carcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Diffuse Glioma 33 / 629 cases (5.2 %) · ssm · difg_glass · largest of 2 cohorts	—	—	Diffuse Glioma	2	Observed	cbioportal	graph →

Radial view

Every edge, grouped by relationship

Paths