RET

ret proto-oncogene

Identifier: CI-GENE-00023348
Entity page: /gene/RET ↗
Edges: 4,303

Neighbours: 12 cancers15 variants14 drugs
Drawn: 41 of 41 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
RET associated with …ASSOCIATED_WITH15 of 16show all (up to 200)
→ associated with	Thyroid Gland Medullary Carcinomasubtype 3 source records aggregated	supports	A	Thyroid Gland Medullary Carcinoma	3	Curated	civic	graph →
→ associated with	Solid Neoplasm

RET targets …TARGETS14 of 14
← targets	Vandetanibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Sunitinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Sorafenib Tosylatesmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Sorafenibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Selpercatinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Regorafenib Anhydroussmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Regorafenibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Quizartinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Pralsetinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	NVP-AST487small_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Motesanibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Lestaurtinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Alectinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Agerafenibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →

RET targets …TARGETS14 of 14

← targets

Vandetanibsmall_molecule

—

INHIBITOR

—

Curated

RET has variant …HAS_VARIANTderived15 of 4,270show all (up to 200)
→ has variant	M918TSNV 15 accepted CIViC evidence items	—	—	Malignant Neoplasm,Thyroid Gland Medullary Carcinoma	15	Curated	civic	graph →
→ has variant	Fusionfusion 12 accepted CIViC evidence items	—	—	Solid Neoplasm,Lung Non-Small Cell Carcinoma,Malignant Thyroid Gland Neoplasm+2	12	Curated	civic	graph →
→ has variant	Mutationother 6 accepted CIViC evidence items	—	—	Solid Neoplasm,Thyroid Gland Medullary Carcinoma	6	Curated	civic	graph →
→ has variant	Fusionfusion 3 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma,Lung Adenocarcinoma	3	Curated	civic	graph →
→ has variant	Overexpressionexpression 3 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm,Papillary Adenocarcinoma,Lung Adenocarcinoma	3	Curated	civic	graph →
→ has variant	E632_L633deldeletion 2 accepted CIViC evidence items	—	—	Malignant Neoplasm,Thyroid Gland Medullary Carcinoma	2	Curated	civic	graph →
→ has variant	Fusionfusion 2 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma,Malignant Colorectal Neoplasm	2	Curated	civic	graph →
→ has variant	G810SSNV 2 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma,Thyroid Gland Medullary Carcinoma	2	Curated	civic	graph →
→ has variant	V804MSNV 2 accepted CIViC evidence items	—	—	Thyroid Gland Medullary Carcinoma	2	Curated	civic	graph →
→ has variant	C609YSNV 1 accepted CIViC evidence items	—	—	Thyroid Gland Medullary Carcinoma	1	Curated	civic	graph →
→ has variant	C618RSNV 1 accepted CIViC evidence items	—	—	Malignant Neoplasm	1	Curated	civic	graph →
→ has variant	C634RSNV 1 accepted CIViC evidence items	—	—	Malignant Neoplasm	1	Curated	civic	graph →
→ has variant	C634WSNV 1 accepted CIViC evidence items	—	—	Thyroid Gland Medullary Carcinoma	1	Curated	civic	graph →
→ has variant	G810CSNV 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	G810RSNV 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →

RET altered in cohorts of …ALTERED_INderived3 of 3
→ altered in cohorts of	Skin Basal Cell Carcinoma 45 / 293 cases (15 %) · ssm · bcc_unige_2016	—	—	Skin Basal Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Endometrial Carcinoma 25 / 181 cases (14 %) · ssm · ucec_ccr_msk_2022	—	—	Endometrial Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Cutaneous Melanoma 60 / 696 cases (8.6 %) · ssm · mel_mskimpact_2020	—	—	Cutaneous Melanoma	1	Observed	cbioportal	graph →

Radial view

Every edge, grouped by relationship

Paths