RET C634R

CI-VAR-00000351Explore in graph →CIViC 1700

Curated evidence

Evidence by cancer (2 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–2 of 2 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Malignant Neoplasm1
RET C634R	(oncogenic)	Oncogenic	D	Supports Oncogenicity	3	accepted	EID11874 In a colony formation assay with NIH3T3 cells, RET C634R was used as a positive control (called MEN2A after its association with that disease). Cells transformed with C634R showed significant colony f… (full text at CIViC) PMID 9191060 · Ceccherini et al., 1997 · Open in CIViC	civic
Thyroid Gland Medullary Carcinoma1
RET C634R	(diagnostic)	Diagnostic	B	Supports Positive	3	submitted	EID4894 Sixty-nine individuals from 12 different families presented a codon 634 mutation, the most prevailing missense mutation in our series. The specific mutations identified were C634Y (n = 49), C634R (n =… (full text at CIViC) PMID 12788868 ·

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.