PGR

progesterone receptor

Identifier: CI-GENE-00019554
Entity page: /gene/PGR ↗
Edges: 10

Neighbours: 2 cancers6 variants2 drugs
Drawn: 10 of 10 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
PGR associated with …ASSOCIATED_WITH1 of 1
→ associated with	Malignant Breast Neoplasmcancer_family 2 source records aggregated	supports	B	Malignant Breast Neoplasm	2	Curated	civic	graph →
PGR targets …TARGETS2 of 2
targets

PGR has variant …HAS_VARIANTderived6 of 6
→ has variant	Expressionexpression 4 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	4	Curated	civic	graph →
→ has variant	LOW EXPRESSIONexpression no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000926.4(PGR):c.1189T>C (p.Ser397Pro)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000926.4(PGR):c.1192G>C (p.Ala398Pro)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000926.4(PGR):c.517G>A (p.Gly173Arg)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000926.4(PGR):c.549A>G (p.Lys183=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

PGR has variant …HAS_VARIANTderived6 of 6

→ has variant

Expressionexpression

4 accepted CIViC evidence items

—

Malignant Breast Neoplasm

Curated

civic

graph →

→ has variant

LOW EXPRESSIONexpression

no accepted CIViC evidence item (variant record only)