PDGFRB

platelet derived growth factor receptor beta

Identifier: CI-GENE-00019278
Entity page: /gene/PDGFRB ↗
Edges: 51

Neighbours: 8 cancers15 variants22 drugs
Drawn: 45 of 45 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

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Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
PDGFRB associated with …ASSOCIATED_WITH7 of 7
→ associated with	Myeloproliferative Neoplasmhematologic_malignancy	supports	A	Myeloproliferative Neoplasm	1	Curated	civic	graph →
→ associated with	Hematopoietic and Lymphoid Cell Neoplasmcancer_family	supports	A

PDGFRB targets …TARGETS22 of 22show fewer
← targets	Vatalanibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Tivozanibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Tandutinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Sunitinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Sorafenib Tosylatesmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Sorafenibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Regorafenib Anhydroussmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Regorafenibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Quizartinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Pazopanibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Nintedanibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Motesanibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Midostaurinsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Masitinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Linifanibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Imatinib Mesylatesmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Imatinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Foretinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Dovitinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Dasatinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Crenolanibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Cediranibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →

PDGFRB targets …TARGETS22 of 22show fewer

← targets

Vatalanibsmall_molecule

—

INHIBITOR

—

Curated

PDGFRB has variant …HAS_VARIANTderived15 of 20show all (up to 200)
→ has variant	Fusionfusion 5 accepted CIViC evidence items	—	—	B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like	5	Curated	civic	graph →
→ has variant	Fusionfusion 3 accepted CIViC evidence items	—	—	Hematopoietic and Lymphoid Cell Neoplasm,Myeloproliferative Neoplasm,Chronic Myelomonocytic Leukemia	3	Curated	civic	graph →
→ has variant	C843GSNV 1 accepted CIViC evidence items	—	—	B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like	1	Curated	civic	graph →
→ has variant	Fusionfusion 1 accepted CIViC evidence items	—	—	B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like	1	Curated	civic	graph →
→ has variant	Fusionfusion 1 accepted CIViC evidence items	—	—	B Acute Lymphoblastic Leukemia	1	Curated	civic	graph →
→ has variant	Overexpressionexpression 1 accepted CIViC evidence items	—	—	Dermatofibrosarcoma Protuberans	1	Curated	civic	graph →
→ has variant	e10::e11fusion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	e6::e11fusion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	e9::e9fusion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	Fusionfusion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	Fusionfusion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	Fusionfusion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	Mutationother no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002609.4(PDGFRB):c.12G>A (p.Pro4=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002609.4(PDGFRB):c.1678_1689del (p.Pro560_Glu563del)deletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

PDGFRB altered in cohorts of …ALTERED_INderived2 of 2
→ altered in cohorts of	Skin Basal Cell Carcinoma 50 / 293 cases (17 %) · ssm · bcc_unige_2016	—	—	Skin Basal Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Cutaneous Melanoma 62 / 696 cases (8.9 %) · ssm · mel_mskimpact_2020	—	—	Cutaneous Melanoma	1	Observed	cbioportal	graph →

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