PDGFRB e10::e11

CI-VAR-00004936Explore in graph →CIViC 5493

Curated evidence

Evidence by cancer (2 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–2 of 2 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
T Acute Lymphoblastic Leukemia2
AGGF1::PDGFRB e10::e11	(oncogenic)	Oncogenic	C	Supports Oncogenicity	4	submitted	EID13004 In frame AGGF1:PDGFRb (exons 1-10 and exons 11-23) containing the PDGFRb tyrosine kinase domain, with no additional mutations, was observed in a 4 year old patient with T-ALL, found by RNAseq and conf… (full text at CIViC) PMID 29284681 · Zabriskie et al., 2018 · Open in CIViC	civic
AGGF1::PDGFRB e10::e11	Dasatinib	Predictive	C	Supports Sensitivity Response	3	submitted	EID13003 A 4 yr old boy presented with a history of 1 week with fatigue, weakness, fever and vomiting. Physical examination showed prominent hepatosplenomegaly and white blood cell count of 622.8x109/L with … (full text at CIViC) PMID 29284681 · Zabriskie et al., 2018 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.