OBSCN

obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF

Identifier: CI-GENE-00017552
Entity page: /gene/OBSCN ↗
Edges: 67

Neighbours: 27 cancers15 variants
Drawn: 42 of 42 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
OBSCN has variant …HAS_VARIANTderived15 of 40show all (up to 200)
→ has variant	NM_001386125.1(OBSCN):c.12137C>G (p.Ala4046Gly)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001386125.1(OBSCN):c.12241A>G (p.Met4081Val)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped

OBSCN altered in cohorts of …ALTERED_INderived27 of 27show fewer
→ altered in cohorts of	Breast Invasive Carcinoma, NOS 806 / 1,098 cases (73 %) · ssm · TCGA-BRCA	—	—	Breast Invasive Carcinoma, NOS	1	Observed	gdc	graph →
→ altered in cohorts of	Endometrial Carcinoma 296 / 559 cases (53 %) · ssm · TCGA-UCEC · largest of 5 cohorts	—	—	Endometrial Carcinoma	5	Observed	gdc	graph →
→ altered in cohorts of	Skin Basal Cell Carcinoma 52 / 126 cases (41 %) · ssm · bcc_unige_2016	—	—	Skin Basal Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Renal Cell Carcinoma 51 / 158 cases (32 %) · ssm · rcc_iatlas_immotion150_2018	—	—	Renal Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Melanoma 45 / 144 cases (31 %) · ssm · mel_dfci_2019 · largest of 3 cohorts	—	—	Melanoma	3	Observed	cbioportal	graph →
→ altered in cohorts of	Adrenal Cortical Carcinoma 27 / 90 cases (30 %) · ssm · acc_tcga	—	—	Adrenal Cortical Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Endometrial Endometrioid Adenocarcinoma 65 / 247 cases (26 %) · ssm · uec_cptac_gdc	—	—	Endometrial Endometrioid Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Skin Squamous Cell Carcinoma 20 / 83 cases (24 %) · ssm · cscc_ucsf_2021 · largest of 2 cohorts	—	—	Skin Squamous Cell Carcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Cutaneous Melanoma 99 / 469 cases (21 %) · ssm · skcm_tcga_gdc · largest of 8 cohorts	—	—	Cutaneous Melanoma	8	Observed	cbioportal	graph →
→ altered in cohorts of	Gastroesophageal Junction Adenocarcinoma 104 / 518 cases (20 %) · ssm · stes_tcga_pub	—	—	Gastroesophageal Junction Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Gastric Adenocarcinoma 95 / 478 cases (20 %) · ssm · stad_tcga · largest of 5 cohorts	—	—	Gastric Adenocarcinoma	5	Observed	cbioportal	graph →
→ altered in cohorts of	Colon Adenocarcinoma 84 / 429 cases (20 %) · ssm · coad_tcga_gdc · largest of 4 cohorts	—	—	Colon Adenocarcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Thymoma 24 / 124 cases (19 %) · ssm · TCGA-THYM	—	—	Thymoma	1	Observed	gdc	graph →
→ altered in cohorts of	Lung Non-Small Cell Carcinoma 167 / 1,144 cases (15 %) · ssm · nsclc_tcga_broad_2016 · largest of 2 cohorts	—	—	Lung Non-Small Cell Carcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Esophageal Adenocarcinoma 27 / 185 cases (15 %) · ssm · esca_tcga	—	—	Esophageal Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Adenocarcinoma 82 / 566 cases (14 %) · ssm · luad_tcga_pan_can_atlas_2018 · largest of 7 cohorts	—	—	Lung Adenocarcinoma	7	Observed	cbioportal	graph →
→ altered in cohorts of	Colorectal Adenocarcinoma 126 / 1,015 cases (12 %) · ssm · crc_sysucc_2022 · largest of 4 cohorts	—	—	Colorectal Adenocarcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Hepatocellular Carcinoma 59 / 494 cases (12 %) · ssm · hcc_clca_2024 · largest of 4 cohorts	—	—	Hepatocellular Carcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Diffuse Glioma 70 / 629 cases (11 %) · ssm · difg_glass · largest of 3 cohorts	—	—	Diffuse Glioma	3	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Squamous Cell Carcinoma 52 / 484 cases (11 %) · ssm · lusc_tcga_pan_can_atlas_2018 · largest of 5 cohorts	—	—	Lung Squamous Cell Carcinoma	5	Observed	cbioportal	graph →
→ altered in cohorts of	Bladder Urothelial Carcinoma 47 / 474 cases (9.9 %) · ssm · blca_msk_tcga_2020 · largest of 5 cohorts	—	—	Bladder Urothelial Carcinoma	5	Observed	cbioportal	graph →
→ altered in cohorts of	Cholangiocarcinoma 31 / 417 cases (7.4 %) · ssm · chol_icgc_2017	—	—	Cholangiocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Invasive Breast Carcinoma 27 / 379 cases (7.1 %) · ssm · brca_mbcproject_2022 · largest of 2 cohorts	—	—	Invasive Breast Carcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Cervical Squamous Cell Carcinoma 20 / 291 cases (6.9 %) · ssm · cesc_tcga_pan_can_atlas_2018 · largest of 2 cohorts	—	—	Cervical Squamous Cell Carcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Multiple Myeloma 64 / 961 cases (6.7 %) · ssm · MMRF-COMMPASS	—	—	Multiple Myeloma	1	Observed	gdc	graph →
→ altered in cohorts of	Head and Neck Squamous Cell Carcinoma 34 / 515 cases (6.6 %) · ssm · hnsc_tcga_pan_can_atlas_2018 · largest of 3 cohorts	—	—	Head and Neck Squamous Cell Carcinoma	3	Observed	cbioportal	graph →
→ altered in cohorts of	Prostate Adenocarcinoma 53 / 1,013 cases (5.2 %) · ssm · prad_p1000 · largest of 2 cohorts	—	—	Prostate Adenocarcinoma	2	Observed	cbioportal	graph →

OBSCN altered in cohorts of …ALTERED_INderived27 of 27show fewer

→ altered in cohorts of

Breast Invasive Carcinoma, NOS

806 / 1,098 cases (73 %) · ssm · TCGA-BRCA

—

Breast Invasive Carcinoma, NOS

Observed

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