MAP2K1

mitogen-activated protein kinase kinase 1

Identifier: CI-GENE-00011949
Entity page: /gene/MAP2K1 ↗
Edges: 49

Neighbours: 6 cancers15 variants7 drugs
Drawn: 28 of 28 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

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Edges

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
MAP2K1 associated with …ASSOCIATED_WITH6 of 6
→ associated with	Lung Adenocarcinomasubtype	supports	B	Lung Adenocarcinoma	1	Curated	civic	graph →
→ associated with	Ovarian Serous Adenocarcinomasubtype	supports	C

MAP2K1 targets …TARGETS7 of 7
← targets	Trametinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Selumetinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Refametinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	RDEA 119small_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Mirdametinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Cobimetinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Binimetinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →

MAP2K1 targets …TARGETS7 of 7

← targets

Trametinibsmall_molecule

—

INHIBITOR

—

Curated

MAP2K1 has variant …HAS_VARIANTderived15 of 34show all (up to 200)
→ has variant	K57NSNV 2 accepted CIViC evidence items	—	—	Lung Adenocarcinoma	2	Curated	civic	graph →
→ has variant	P124SSNV 2 accepted CIViC evidence items	—	—	Malignant Neoplasm,Melanoma	2	Curated	civic	graph →
→ has variant	C121SSNV 1 accepted CIViC evidence items	—	—	Melanoma	1	Curated	civic	graph →
→ has variant	Q56PSNV 1 accepted CIViC evidence items	—	—	Melanoma	1	Curated	civic	graph →
→ has variant	Q56_V60deldeletion 1 accepted CIViC evidence items	—	—	Ovarian Serous Adenocarcinoma	1	Curated	civic	graph →
→ has variant	56_61QKQKVG>R no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	E102_I103delEIdeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	E203KSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	F53LSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	F53YSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	G128DSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	G128VSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	G276WSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	K57_G61deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	K57TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

MAP2K1 altered in cohorts of …ALTERED_INderived2 of 2
→ altered in cohorts of	Histiocytic and Dendritic Cell Neoplasm 113 / 1,270 cases (8.9 %) · ssm · hdcn_msk_2025	—	—	Histiocytic and Dendritic Cell Neoplasm	1	Observed	cbioportal	graph →
→ altered in cohorts of	Cutaneous Melanoma 59 / 696 cases (8.5 %) · ssm · mel_mskimpact_2020	—	—	Cutaneous Melanoma	1	Observed	cbioportal	graph →

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