MAP2K1 C121S

CI-VAR-00000266Explore in graph →NP_002746.1:p.Cys121SerNM_002755.3:c.362G>CClinVar 375980 CIViC 627

Curated evidence

Evidence by cancer (3 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–3 of 3 evidence items across 3 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Langerhans Cell Histiocytosis1
MAP2K1 C121S AND MAP2K1 G128D	Trametinib	Predictive	D	Supports Resistance	3	submitted	EID6385 The C121S/G128D and 56_61QKQKVG>R variants were resistant to the mitogen-activated protein kinase kinase (MEK) inhibitor trametinib in vitro. All three variant proteins constitutively phosphorylated E… (full text at CIViC) PMID 25899310 · Nelson et al., 2015 · Open in CIViC	civic
Malignant Colorectal Neoplasm1
BRAF V600E AND MAP2K1 C121S	Cetuximab + Irinotecan + VemurafenibCombination	Predictive	C	Supports Resistance	2	submitted	EID1903 Phase 1b study of vemurafenib, cetuximab and irinotecan in 19 BRAF V600E mutant colorectal cancer patients. cfDNA panel sequencing was performed in 10 patients after disease progression. Three patient…

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.

Melanoma1
MAP2K1 C121S	Vemurafenib	Predictive	C	Supports Resistance	4	accepted	EID1602 A patient with BRAF-mutant melanoma relapsed after treatment with PLX4032 (vemurafenib). The MAP2K1 C121S mutation was identified as a relapse-specific variant and was undetectable in the pre-treatmen… (full text at CIViC) PMID 21383288 · Wagle et al., 2011 · Open in CIViC	civic