KDR

kinase insert domain receptor

Identifier: CI-GENE-00006819
Entity page: /gene/KDR ↗
Edges: 68

Neighbours: 7 cancers15 variants15 drugs
Drawn: 37 of 37 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
KDR associated with …ASSOCIATED_WITH3 of 3
→ associated with	Colorectal Adenocarcinomasubtype	supports	C	Colorectal Adenocarcinoma	1	Curated	civic	graph →
→ associated with	Angiosarcomasubtype 2 source records aggregated	supports	D

KDR targets …TARGETS15 of 23show all (up to 200)
← targets	Vatalanibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Vandetanibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Tivozanibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Sunitinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Sorafenib Tosylatesmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Sorafenibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Regorafenib Anhydroussmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Regorafenibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Ramucirumabmonoclonal_antibody	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Pazopanibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Nintedanibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Ningetinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Motesanibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Midostaurinsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Lucitanibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →

KDR targets …TARGETS15 of 23show all (up to 200)

← targets

Vatalanibsmall_molecule

—

INHIBITOR

—

Curated

KDR has variant …HAS_VARIANTderived15 of 38show all (up to 200)
→ has variant	A1065TSNV 1 accepted CIViC evidence items	—	—	Angiosarcoma	1	Curated	civic	graph →
→ has variant	D717VSNV 1 accepted CIViC evidence items	—	—	Angiosarcoma	1	Curated	civic	graph →
→ has variant	R1032QSNV 1 accepted CIViC evidence items	—	—	Malignant Colorectal Neoplasm	1	Curated	civic	graph →
→ has variant	R961WSNV 1 accepted CIViC evidence items	—	—	Colorectal Adenocarcinoma	1	Curated	civic	graph →
→ has variant	Amplificationamplification no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	G800DSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	G800RSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	G843DSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	L840FSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	Mutationother no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002253.4(KDR):c.1384T>G (p.Leu462Val)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002253.4(KDR):c.1416A>T (p.Gln472His)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002253.4(KDR):c.2360G>A (p.Arg787Gln)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002253.4(KDR):c.2380G>A (p.Gly794Arg)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002253.4(KDR):c.2509+20T>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

KDR altered in cohorts of …ALTERED_INderived4 of 4
→ altered in cohorts of	Skin Basal Cell Carcinoma 120 / 293 cases (41 %) · ssm · bcc_unige_2016	—	—	Skin Basal Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Cutaneous Melanoma 131 / 696 cases (19 %) · ssm · mel_mskimpact_2020	—	—	Cutaneous Melanoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Non-Small Cell Carcinoma 20 / 322 cases (6.2 %) · ssm · bm_nsclc_mskcc_2023	—	—	Lung Non-Small Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Invasive Breast Carcinoma 32 / 527 cases (6.1 %) · ssm · brca_msk_2025	—	—	Invasive Breast Carcinoma	1	Observed	cbioportal	graph →

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