IDH1

isocitrate dehydrogenase (NADP(+)) 1

Identifier: CI-GENE-00005338
Entity page: /gene/IDH1 ↗
Edges: 55

Neighbours: 14 cancers15 variants4 drugs
Drawn: 33 of 33 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

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Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
IDH1 associated with …ASSOCIATED_WITH15 of 17show all (up to 200)
→ associated with	Acute Myeloid Leukemiahematologic_malignancy	supports	A	Acute Myeloid Leukemia	1	Curated	civic	graph →
→ associated with	Gliomasubtype	supports

IDH1 targets …TARGETS4 of 4
← targets	Vorasidenibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Safusidenibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Olutasidenibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Ivosidenibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →

IDH1 targets …TARGETS4 of 4

← targets

Vorasidenibsmall_molecule

—

INHIBITOR

—

Curated

IDH1 has variant …HAS_VARIANTderived15 of 26show all (up to 200)
→ has variant	R132 11 accepted CIViC evidence items	—	—	Anaplastic Astrocytoma,Glioblastoma,Myelodysplastic Syndrome+2	11	Curated	civic	graph →
→ has variant	R132CSNV 10 accepted CIViC evidence items	—	—	Malignant Neoplasm,Acute Myeloid Leukemia,Low Grade Glioma+1	10	Curated	civic	graph →
→ has variant	Mutationother 7 accepted CIViC evidence items	—	—	Chondrosarcoma,Glioma,Acute Myeloid Leukemia+1	7	Curated	civic	graph →
→ has variant	R132HSNV 4 accepted CIViC evidence items	—	—	Acute Myeloid Leukemia,Low Grade Glioma,Oligodendroglioma+1	4	Curated	civic	graph →
→ has variant	R132GSNV 1 accepted CIViC evidence items	—	—	Low Grade Glioma	1	Curated	civic	graph →
→ has variant	R132LSNV 1 accepted CIViC evidence items	—	—	Low Grade Glioma	1	Curated	civic	graph →
→ has variant	R132SSNV 1 accepted CIViC evidence items	—	—	Low Grade Glioma	1	Curated	civic	graph →
→ has variant	NM_005896.4(IDH1):c.217T>G (p.Cys73Gly)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005896.4(IDH1):c.224C>T (p.Thr75Ile)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005896.4(IDH1):c.315C>G (p.Gly105=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005896.4(IDH1):c.315C>T (p.Gly105=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005896.4(IDH1):c.394C>G (p.Arg132Gly)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005896.4(IDH1):c.415-238A>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005896.4(IDH1):c.59G>A (p.Arg20Gln)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005896.4(IDH1):c.659A>G (p.Asp220Gly)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

IDH1 altered in cohorts of …ALTERED_INderived8 of 8
→ altered in cohorts of	Low Grade Gliomasubtype 402 / 516 cases (78 %) · ssm · TCGA-LGG	—	—	Low Grade Glioma	1	Observed	gdc	graph →
→ altered in cohorts of	Diffuse Glioma 339 / 1,004 cases (34 %) · ssm · glioma_mskcc_2019 · largest of 12 cohorts	—	—	Diffuse Glioma	12	Observed	cbioportal	graph →
→ altered in cohorts of	Prostate Adenocarcinoma 29 / 99 cases (29 %) · ssm · prad_idhmut_msk_2025	—	—	Prostate Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Cholangiocarcinomasubtype 48 / 195 cases (25 %) · ssm · chol_msk_2018	—	—	Cholangiocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Intrahepatic Cholangiocarcinoma 85 / 412 cases (21 %) · ssm · ihch_msk_2021 · largest of 2 cohorts	—	—	Intrahepatic Cholangiocarcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Hepatocellular Carcinoma 141 / 1,370 cases (10 %) · ssm · hcc_msk_2024	—	—	Hepatocellular Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Acute Myeloid Leukemiahematologic_malignancy 71 / 903 cases (7.9 %) · ssm · aml_ohsu_2022 · largest of 2 cohorts	—	—	Acute Myeloid Leukemia	2	Observed	cbioportal	graph →
→ altered in cohorts of	Myelodysplastic Syndromehematologic_malignancy 263 / 4,231 cases (6.2 %) · ssm · mds_mskcc_2020	—	—	Myelodysplastic Syndrome	1	Observed	cbioportal	graph →

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