FAT4

FAT atypical cadherin 4

Identifier: CI-GENE-00001652
Entity page: /gene/FAT4 ↗
Edges: 46

Neighbours: 24 cancers15 variants
Drawn: 39 of 39 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Edges

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
FAT4 has variant …HAS_VARIANTderived15 of 22show all (up to 200)
→ has variant	NM_001291303.3(FAT4):c.10093C>A (p.Arg3365=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001291303.3(FAT4):c.10158A>G (p.Ala3386=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0

FAT4 altered in cohorts of …ALTERED_INderived24 of 24show fewer
→ altered in cohorts of	Skin Basal Cell Carcinoma 57 / 126 cases (45 %) · ssm · bcc_unige_2016	—	—	Skin Basal Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Skin Squamous Cell Carcinoma 35 / 83 cases (42 %) · ssm · cscc_ucsf_2021 · largest of 3 cohorts	—	—	Skin Squamous Cell Carcinoma	3	Observed	cbioportal	graph →
→ altered in cohorts of	Cutaneous Melanoma 148 / 469 cases (32 %) · ssm · skcm_tcga_gdc · largest of 8 cohorts	—	—	Cutaneous Melanoma	8	Observed	cbioportal	graph →
→ altered in cohorts of	Melanoma 43 / 144 cases (30 %) · ssm · mel_dfci_2019 · largest of 2 cohorts	—	—	Melanoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Colon Adenocarcinoma 99 / 429 cases (23 %) · ssm · coad_tcga_gdc · largest of 4 cohorts	—	—	Colon Adenocarcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Endometrial Carcinoma 108 / 517 cases (21 %) · ssm · ucec_tcga_pan_can_atlas_2018 · largest of 4 cohorts	—	—	Endometrial Carcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Gastroesophageal Junction Adenocarcinoma 99 / 518 cases (19 %) · ssm · stes_tcga_pub	—	—	Gastroesophageal Junction Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Gastric Adenocarcinoma 85 / 478 cases (18 %) · ssm · stad_tcga · largest of 4 cohorts	—	—	Gastric Adenocarcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Rectal Adenocarcinoma 25 / 155 cases (16 %) · ssm · read_tcga_gdc	—	—	Rectal Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Endometrial Endometrioid Adenocarcinoma 39 / 247 cases (16 %) · ssm · uec_cptac_gdc	—	—	Endometrial Endometrioid Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Adenocarcinoma 86 / 566 cases (15 %) · ssm · luad_tcga_pan_can_atlas_2018 · largest of 7 cohorts	—	—	Lung Adenocarcinoma	7	Observed	cbioportal	graph →
→ altered in cohorts of	Renal Cell Carcinoma 24 / 158 cases (15 %) · ssm · rcc_iatlas_immotion150_2018	—	—	Renal Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Diffuse Large B-Cell Lymphoma Unclassifiable 20 / 135 cases (15 %) · ssm · dlbcl_dfci_2018	—	—	Diffuse Large B-Cell Lymphoma Unclassifiable	1	Observed	cbioportal	graph →
→ altered in cohorts of	Esophageal Adenocarcinoma 25 / 185 cases (14 %) · ssm · esca_tcga · largest of 2 cohorts	—	—	Esophageal Adenocarcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Squamous Cell Carcinoma 65 / 484 cases (13 %) · ssm · lusc_tcga_pan_can_atlas_2018 · largest of 4 cohorts	—	—	Lung Squamous Cell Carcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Non-Small Cell Carcinoma 153 / 1,144 cases (13 %) · ssm · nsclc_tcga_broad_2016 · largest of 2 cohorts	—	—	Lung Non-Small Cell Carcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	B-Cell Non-Hodgkin Lymphoma 37 / 297 cases (12 %) · ssm · mbn_sfu_2023	—	—	B-Cell Non-Hodgkin Lymphoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Colorectal Adenocarcinoma 112 / 1,015 cases (11 %) · ssm · crc_sysucc_2022 · largest of 5 cohorts	—	—	Colorectal Adenocarcinoma	5	Observed	cbioportal	graph →
→ altered in cohorts of	Bladder Urothelial Carcinoma 52 / 474 cases (11 %) · ssm · blca_msk_tcga_2020 · largest of 5 cohorts	—	—	Bladder Urothelial Carcinoma	5	Observed	cbioportal	graph →
→ altered in cohorts of	Multiple Myeloma 84 / 961 cases (8.7 %) · ssm · MMRF-COMMPASS	—	—	Multiple Myeloma	1	Observed	gdc	graph →
→ altered in cohorts of	Head and Neck Squamous Cell Carcinoma 41 / 515 cases (8.0 %) · ssm · hnsc_tcga_pan_can_atlas_2018 · largest of 4 cohorts	—	—	Head and Neck Squamous Cell Carcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Hepatocellular Carcinoma 31 / 494 cases (6.3 %) · ssm · hcc_clca_2024	—	—	Hepatocellular Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Prostate Adenocarcinoma 24 / 444 cases (5.4 %) · ssm · prad_su2c_2019	—	—	Prostate Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Diffuse Glioma 23 / 444 cases (5.2 %) · ssm · difg_glass_2019	—	—	Diffuse Glioma	1	Observed	cbioportal	graph →

FAT4 altered in cohorts of …ALTERED_INderived24 of 24show fewer

→ altered in cohorts of

Skin Basal Cell Carcinoma

57 / 126 cases (45 %) · ssm · bcc_unige_2016

—

Skin Basal Cell Carcinoma

Observed

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