FAT1

FAT atypical cadherin 1

Identifier: CI-GENE-00001648
Entity page: /gene/FAT1 ↗
Edges: 60

Neighbours: 22 cancers15 variants
Drawn: 37 of 37 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
FAT1 has variant …HAS_VARIANTderived15 of 38show all (up to 200)
→ has variant	Lossdeletion_cna no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005245.4(FAT1):c.10161del (p.Val3388fs)deletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed

FAT1 altered in cohorts of …ALTERED_INderived22 of 22show fewer
→ altered in cohorts of	Skin Squamous Cell Carcinoma 25 / 83 cases (30 %) · ssm · cscc_ucsf_2021	—	—	Skin Squamous Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Head and Neck Carcinoma, Other 25 / 108 cases (23 %) · ssm · ohnca_cptac_gdc	—	—	Head and Neck Carcinoma, Other	1	Observed	cbioportal	graph →
→ altered in cohorts of	Head and Neck Squamous Cell Carcinoma 111 / 515 cases (22 %) · ssm · hnsc_tcga_pan_can_atlas_2018 · largest of 4 cohorts	—	—	Head and Neck Squamous Cell Carcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Endometrial Carcinoma 103 / 517 cases (20 %) · ssm · ucec_tcga_pan_can_atlas_2018 · largest of 6 cohorts	—	—	Endometrial Carcinoma	6	Observed	cbioportal	graph →
→ altered in cohorts of	Cutaneous Melanoma 136 / 696 cases (20 %) · ssm · mel_mskimpact_2020	—	—	Cutaneous Melanoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Invasive Breast Carcinoma 89 / 527 cases (17 %) · ssm · brca_msk_2025	—	—	Invasive Breast Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Renal Cell Carcinoma 24 / 158 cases (15 %) · ssm · rcc_iatlas_immotion150_2018	—	—	Renal Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Squamous Cell Carcinoma 68 / 484 cases (14 %) · ssm · lusc_tcga_pan_can_atlas_2018 · largest of 4 cohorts	—	—	Lung Squamous Cell Carcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Non-Small Cell Carcinoma 142 / 1,144 cases (12 %) · ssm · nsclc_tcga_broad_2016 · largest of 5 cohorts	—	—	Lung Non-Small Cell Carcinoma	5	Observed	cbioportal	graph →
→ altered in cohorts of	Bladder Urothelial Carcinoma 58 / 474 cases (12 %) · ssm · blca_msk_tcga_2020 · largest of 6 cohorts	—	—	Bladder Urothelial Carcinoma	6	Observed	cbioportal	graph →
→ altered in cohorts of	Endometrial Endometrioid Adenocarcinoma 29 / 247 cases (12 %) · ssm · uec_cptac_gdc	—	—	Endometrial Endometrioid Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Colon Adenocarcinoma 43 / 429 cases (10 %) · ssm · coad_tcga_gdc · largest of 2 cohorts	—	—	Colon Adenocarcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	B-Cell Non-Hodgkin Lymphoma 65 / 755 cases (8.6 %) · ssm · mbn_mdacc_2013 · largest of 3 cohorts	—	—	B-Cell Non-Hodgkin Lymphoma	3	Observed	cbioportal	graph →
→ altered in cohorts of	Gastric Adenocarcinoma 37 / 436 cases (8.5 %) · ssm · stad_tcga_pan_can_atlas_2018 · largest of 3 cohorts	—	—	Gastric Adenocarcinoma	3	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Adenocarcinoma 222 / 2,653 cases (8.4 %) · ssm · luad_mskcc_2023_met_organotropism · largest of 10 cohorts	—	—	Lung Adenocarcinoma	10	Observed	cbioportal	graph →
→ altered in cohorts of	Gastroesophageal Junction Adenocarcinoma 41 / 518 cases (7.9 %) · ssm · stes_tcga_pub	—	—	Gastroesophageal Junction Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Cervical Squamous Cell Carcinoma 23 / 291 cases (7.9 %) · ssm · cesc_tcga_pan_can_atlas_2018 · largest of 2 cohorts	—	—	Cervical Squamous Cell Carcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Rectal Adenocarcinoma 550 / 7,237 cases (7.6 %) · ssm · crc_msk_2026	—	—	Rectal Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Colorectal Adenocarcinoma 78 / 1,134 cases (6.9 %) · ssm · crc_msk_2017 · largest of 4 cohorts	—	—	Colorectal Adenocarcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Multiple Myeloma 54 / 961 cases (5.6 %) · ssm · MMRF-COMMPASS	—	—	Multiple Myeloma	1	Observed	gdc	graph →
→ altered in cohorts of	Diffuse Glioma 48 / 882 cases (5.4 %) · ssm · glioma_mskcc_2019 · largest of 3 cohorts	—	—	Diffuse Glioma	3	Observed	cbioportal	graph →
→ altered in cohorts of	Adenoid Cystic Carcinoma 57 / 1,049 cases (5.4 %) · ssm · acc_2019	—	—	Adenoid Cystic Carcinoma	1	Observed	cbioportal	graph →

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