EZH2

enhancer of zeste 2 polycomb repressive complex 2 subunit

Identifier: CI-GENE-00001160
Entity page: /gene/EZH2 ↗
Edges: 52

Neighbours: 11 cancers15 variants1 drugs
Drawn: 27 of 27 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

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Edges

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
EZH2 associated with …ASSOCIATED_WITH14 of 14
→ associated with	B-Cell Non-Hodgkin Lymphomahematologic_malignancy	supports	A	B-Cell Non-Hodgkin Lymphoma	1	Curated	civic	graph →
→ associated with	Follicular Lymphomahematologic_malignancy	supports	A

EZH2 targets …TARGETS1 of 1
← targets	Tazemetostatsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →

EZH2 targets …TARGETS1 of 1

← targets

Tazemetostatsmall_molecule

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INHIBITOR

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Curated

EZH2 has variant …HAS_VARIANTderived15 of 34show all (up to 200)
→ has variant	Y646FSNV 8 accepted CIViC evidence items	—	—	B-Cell Malignant Neoplasm,Melanoma,B-Cell Non-Hodgkin Lymphoma+2	8	Curated	civic	graph →
→ has variant	Y646NSNV 8 accepted CIViC evidence items	—	—	B-Cell Non-Hodgkin Lymphoma,Diffuse Large B-Cell Lymphoma,Follicular Lymphoma	8	Curated	civic	graph →
→ has variant	A682GSNV 7 accepted CIViC evidence items	—	—	B-Cell Non-Hodgkin Lymphoma,Diffuse Large B-Cell Lymphoma,Follicular Lymphoma	7	Curated	civic	graph →
→ has variant	Y646HSNV 6 accepted CIViC evidence items	—	—	B-Cell Non-Hodgkin Lymphoma,Diffuse Large B-Cell Lymphoma,Follicular Lymphoma	6	Curated	civic	graph →
→ has variant	Y646CSNV 5 accepted CIViC evidence items	—	—	B-Cell Non-Hodgkin Lymphoma,Diffuse Large B-Cell Lymphoma,Follicular Lymphoma	5	Curated	civic	graph →
→ has variant	Y646SSNV 5 accepted CIViC evidence items	—	—	B-Cell Non-Hodgkin Lymphoma,Diffuse Large B-Cell Lymphoma,Follicular Lymphoma	5	Curated	civic	graph →
→ has variant	A692VSNV 4 accepted CIViC evidence items	—	—	B-Cell Non-Hodgkin Lymphoma,Diffuse Large B-Cell Lymphoma,Follicular Lymphoma	4	Curated	civic	graph →
→ has variant	Y646 4 accepted CIViC evidence items	—	—	Cutaneous Melanoma,Diffuse Large B-Cell Lymphoma,Follicular Lymphoma	4	Curated	civic	graph →
→ has variant	Activating Mutation 2 accepted CIViC evidence items	—	—	Follicular Lymphoma	2	Curated	civic	graph →
→ has variant	Mutationother 2 accepted CIViC evidence items	—	—	Myelodysplastic Syndrome,Follicular Lymphoma	2	Curated	civic	graph →
→ has variant	expressionexpression 1 accepted CIViC evidence items	—	—	Diffuse Large B-Cell Lymphoma Germinal Center B-Cell Type	1	Curated	civic	graph →
→ has variant	Intron 6 Mutation 1 accepted CIViC evidence items	—	—	Malignant Colorectal Neoplasm	1	Curated	civic	graph →
→ has variant	Overexpressionexpression 1 accepted CIViC evidence items	—	—	Malignant Neoplasm	1	Curated	civic	graph →
→ has variant	A638GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	C576WSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

EZH2 altered in cohorts of …ALTERED_INderived3 of 3
→ altered in cohorts of	B-Cell Non-Hodgkin Lymphomahematologic_malignancy 64 / 755 cases (8.5 %) · ssm · mbn_mdacc_2013 · largest of 2 cohorts	—	—	B-Cell Non-Hodgkin Lymphoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Myelodysplastic Syndromehematologic_malignancy 243 / 3,323 cases (7.3 %) · ssm · mds_iwg_2022	—	—	Myelodysplastic Syndrome	1	Observed	cbioportal	graph →
→ altered in cohorts of	Diffuse Large B-Cell Lymphoma Unclassifiable 61 / 1,001 cases (6.1 %) · ssm · dlbcl_duke_2017	—	—	Diffuse Large B-Cell Lymphoma Unclassifiable	1	Observed	cbioportal	graph →

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