DNMT3A

DNA methyltransferase 3 alpha

Identifier: CI-GENE-00043700
Entity page: /gene/DNMT3A ↗
Edges: 60

Neighbours: 7 cancers15 variants2 drugs
Drawn: 24 of 24 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

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Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
DNMT3A associated with …ASSOCIATED_WITH4 of 4
→ associated with	Acute Myeloid Leukemiahematologic_malignancy 24 source records aggregated	supports	B	Acute Myeloid Leukemia	24	Curated	civic	graph →
→ associated with	Malignant Neoplasmcancer_family

DNMT3A targets …TARGETS2 of 2
← targets	Decitabinesmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Azacitidinesmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →

DNMT3A has variant …HAS_VARIANTderived15 of 49show all (up to 200)
→ has variant	R882SNV 27 accepted CIViC evidence items	—	—	Acute Myeloid Leukemia	27	Curated	civic	graph →
→ has variant	Mutationother 7 accepted CIViC evidence items	—	—	Malignant Neoplasm,Myelodysplastic Syndrome,Acute Myeloid Leukemia+1	7	Curated	civic	graph →
→ has variant	K577XSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_022552.5(DNMT3A):c.1015-3C>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_022552.5(DNMT3A):c.1035_1045del (p.Met345fs)deletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_022552.5(DNMT3A):c.1095C>A (p.Tyr365Ter)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_022552.5(DNMT3A):c.1204C>T (p.Gln402Ter)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_022552.5(DNMT3A):c.120G>A (p.Glu40=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_022552.5(DNMT3A):c.1319G>A (p.Trp440Ter)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_022552.5(DNMT3A):c.1609T>A (p.Cys537Ser)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_022552.5(DNMT3A):c.1676G>A (p.Cys559Tyr)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_022552.5(DNMT3A):c.1803G>A (p.Trp601Ter)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_022552.5(DNMT3A):c.1903C>T (p.Arg635Trp)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_022552.5(DNMT3A):c.1935_1936del (p.Gly646fs)deletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_022552.5(DNMT3A):c.1959G>C (p.Leu653Phe)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

DNMT3A altered in cohorts of …ALTERED_INderived5 of 5
→ altered in cohorts of	Acute Myeloid Leukemiahematologic_malignancy 197 / 903 cases (22 %) · ssm · aml_ohsu_2022 · largest of 5 cohorts	—	—	Acute Myeloid Leukemia	5	Observed	cbioportal	graph →
→ altered in cohorts of	Myelodysplastic Syndromehematologic_malignancy 853 / 4,231 cases (20 %) · ssm · mds_mskcc_2020 · largest of 2 cohorts	—	—	Myelodysplastic Syndrome	2	Observed	cbioportal	graph →
→ altered in cohorts of	T-Cell Non-Hodgkin Lymphoma 25 / 132 cases (19 %) · ssm · mtnn_msk_2022	—	—	T-Cell Non-Hodgkin Lymphoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Histiocytic and Dendritic Cell Neoplasm 104 / 1,270 cases (8.2 %) · ssm · hdcn_msk_2025	—	—	Histiocytic and Dendritic Cell Neoplasm	1	Observed	cbioportal	graph →
→ altered in cohorts of	Invasive Breast Carcinoma 30 / 527 cases (5.7 %) · ssm · brca_msk_2025	—	—	Invasive Breast Carcinoma	1	Observed	cbioportal	graph →

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