DNMT3A R882

CI-VAR-00003921Explore in graph →ClinVar 375881 CIViC 32 rs147001633

Curated evidence

Evidence by cancer (28 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–28 of 28 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Acute Myeloid Leukemia28
DNMT3A R882	(diagnostic)	Diagnostic	B	Supports Positive	2	rejected	EID3 DNMT3A R882 mutations occur most often in de novo AML patients with intermediate risk cytogenetics (39/194 intermediate risk patients vs 0/89 low and high risk). PMID 22081665 · LaRochelle et al., 2011 · Open in CIViC	civic
DNMT3A R882	(diagnostic)	Diagnostic	B	Supports Positive	3	accepted	EID4 Young AML patients (<60 years old) with DNMT3A mutations (60% of which were R882) were older in age, had higher white blood cell counts and had higher platelet counts than patients wildtype for DNMT3A… (full text at CIViC) PMID 22490330 · Ribeiro et al., 2012 · Open in CIViC	civic
DNMT3A R882	(prognostic)

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
375881	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts	2	Tatton-Brown-Rahman overgrowth syndrome; Acute myeloid leukemia; Inborn genetic diseases; Abnormality of the nervous system; Clonal Cytopenia of Undetermined Significance; Intellectual disability; DNMT3A-related disorder; Neoplasm; EBV-positive nodal T- and NK-cell lymphoma	germline/somatic	20