CDKN2A

cyclin dependent kinase inhibitor 2A

Identifier: CI-GENE-00040778
Entity page: /gene/CDKN2A ↗
Edges: 1,567

Neighbours: 23 cancers15 variants
Drawn: 38 of 38 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

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Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
CDKN2A associated with …ASSOCIATED_WITH13 of 13
→ associated with	Malignant Oropharyngeal Neoplasmcancer	supports	A	Malignant Oropharyngeal Neoplasm	1	Curated	civic	graph →
→ associated with	Head and Neck Squamous Cell Carcinomasubtype 5 source records aggregated

CDKN2A has variant …HAS_VARIANTderived15 of 1,539show all (up to 200)
→ has variant	Lossdeletion_cna 13 accepted CIViC evidence items	—	—	Acute Lymphoblastic Leukemia,Cutaneous Melanoma,Ewing Sarcoma+2	13	Curated	civic	graph →
→ has variant	p16 Expressionexpression 10 accepted CIViC evidence items	—	—	Head and Neck Squamous Cell Carcinoma,Lung Non-Small Cell Carcinoma,Malignant Oropharyngeal Neoplasm	10	Curated	civic	graph →
→ has variant	Mutationother 5 accepted CIViC evidence items	—	—	Malignant Pancreatic Neoplasm,Lung Non-Small Cell Carcinoma,Malignant Biliary Tract Neoplasm+1	5	Curated	civic	graph →
→ has variant	Promoter Hypermethylationepigenetic 2 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	2	Curated	civic	graph →
→ has variant	c.151-1G>CSNV 1 accepted CIViC evidence items	—	—	Melanoma	1	Curated	civic	graph →
→ has variant	Deletiondeletion_cna 1 accepted CIViC evidence items	—	—	Childhood Low Grade Glioma	1	Curated	civic	graph →
→ has variant	RS3814960 1 accepted CIViC evidence items	—	—	Esophageal Squamous Cell Carcinoma	1	Curated	civic	graph →
→ has variant	A20PSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	alterationother no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	D108HSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	D108NSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	D108YSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	D84GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	D84HSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	D84NSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

CDKN2A has variant …HAS_VARIANTderived15 of 1,539show all (up to 200)

→ has variant

Lossdeletion_cna

13 accepted CIViC evidence items

—

Acute Lymphoblastic Leukemia,Cutaneous Melanoma,Ewing Sarcoma+2

Curated

CDKN2A altered in cohorts of …ALTERED_INderived15 of 15
→ altered in cohorts of	Head and Neck Squamous Cell Carcinomasubtype 384 / 528 cases (73 %) · ssm · TCGA-HNSC · largest of 5 cohorts	—	—	Head and Neck Squamous Cell Carcinoma	5	Observed	gdc	graph →
→ altered in cohorts of	Esophageal Carcinoma 134 / 185 cases (72 %) · ssm · TCGA-ESCA	—	—	Esophageal Carcinoma	1	Observed	gdc	graph →
→ altered in cohorts of	Sarcoma 139 / 261 cases (53 %) · ssm · TCGA-SARC	—	—	Sarcoma	1	Observed	gdc	graph →
→ altered in cohorts of	Acute Lymphoblastic Leukemiahematologic_malignancy 209 / 768 cases (27 %) · ssm · TARGET-ALL-P2	—	—	Acute Lymphoblastic Leukemia	1	Observed	gdc	graph →
→ altered in cohorts of	Skin Squamous Cell Carcinoma 22 / 83 cases (27 %) · ssm · cscc_ucsf_2021 · largest of 2 cohorts	—	—	Skin Squamous Cell Carcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Head and Neck Carcinoma, Other 28 / 108 cases (26 %) · ssm · ohnca_cptac_gdc	—	—	Head and Neck Carcinoma, Other	1	Observed	cbioportal	graph →
→ altered in cohorts of	Cutaneous Melanomacancer 140 / 696 cases (20 %) · ssm · mel_mskimpact_2020 · largest of 3 cohorts	—	—	Cutaneous Melanoma	3	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Squamous Cell Carcinoma 73 / 484 cases (15 %) · ssm · lusc_tcga_pan_can_atlas_2018 · largest of 4 cohorts	—	—	Lung Squamous Cell Carcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Esophageal Adenocarcinoma 21 / 185 cases (11 %) · ssm · esca_tcga · largest of 2 cohorts	—	—	Esophageal Adenocarcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Gastroesophageal Junction Adenocarcinoma 37 / 341 cases (11 %) · ssm · egc_msk_2017 · largest of 2 cohorts	—	—	Gastroesophageal Junction Adenocarcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Gallbladder Carcinoma 26 / 244 cases (11 %) · ssm · gbc_mskcc_2022	—	—	Gallbladder Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Pancreatic Adenocarcinoma 37 / 412 cases (9.0 %) · ssm · pancreas_ctdna_msk_2025 · largest of 8 cohorts	—	—	Pancreatic Adenocarcinoma	8	Observed	cbioportal	graph →
→ altered in cohorts of	Bladder Urothelial Carcinomasubtype 31 / 474 cases (6.5 %) · ssm · blca_msk_tcga_2020 · largest of 6 cohorts	—	—	Bladder Urothelial Carcinoma	6	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Adenocarcinoma 137 / 2,653 cases (5.2 %) · ssm · luad_mskcc_2023_met_organotropism · largest of 2 cohorts	—	—	Lung Adenocarcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Non-Small Cell Carcinomasubtype 63 / 1,257 cases (5.0 %) · ssm · nsclc_ctdx_msk_2022 · largest of 3 cohorts	—	—	Lung Non-Small Cell Carcinoma	3	Observed	cbioportal	graph →

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