BCL2

BCL2 apoptosis regulator

Identifier: CI-GENE-00021693
Entity page: /gene/BCL2 ↗
Edges: 36

Neighbours: 7 cancers25 variants1 drugs
Drawn: 33 of 33 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
BCL2 associated with …ASSOCIATED_WITH6 of 6
→ associated with	Diffuse Large B-Cell Lymphomahematologic_malignancy 2 source records aggregated	supports	B	Diffuse Large B-Cell Lymphoma	2	Curated	civic	graph →
→ associated with	Follicular Lymphomahematologic_malignancy	supports

BCL2 targets …TARGETS1 of 1
← targets	Venetoclaxsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →

BCL2 targets …TARGETS1 of 1

← targets

Venetoclaxsmall_molecule

—

INHIBITOR

—

Curated

BCL2 has variant …HAS_VARIANTderived25 of 25show fewer
→ has variant	F104ISNV 2 accepted CIViC evidence items	—	—	Follicular Lymphoma	2	Curated	civic	graph →
→ has variant	G101VSNV 2 accepted CIViC evidence items	—	—	Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma,Chronic Lymphocytic Leukemia	2	Curated	civic	graph →
→ has variant	Mutationother 1 accepted CIViC evidence items	—	—	Follicular Lymphoma	1	Curated	civic	graph →
→ has variant	Overexpressionexpression 1 accepted CIViC evidence items	—	—	Diffuse Large B-Cell Lymphoma	1	Curated	civic	graph →
→ has variant	reg_e@[IGH]::BCL2fusion 1 accepted CIViC evidence items	—	—	Diffuse Large B-Cell Lymphoma	1	Curated	civic	graph →
→ has variant	A113GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	D103ESNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	D103VSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	D103YSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	F104LSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	F104SSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	G101ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	L119VSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	LOSS-OF-FUNCTION no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000633.3(BCL2):c.178G>A (p.Ala60Thr)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000633.3(BCL2):c.-289C>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000633.3(BCL2):c.353A>C (p.Gln118Pro)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000633.3(BCL2):c.398T>C (p.Val133Ala)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000633.3(BCL2):c.39G>C (p.Glu13Asp)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000633.3(BCL2):c.51G>C (p.Lys17Asn)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000633.3(BCL2):c.607G>A (p.Gly203Ser)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	R107_R110dup no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	R129LSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	Translocationstructural no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	V156DSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

BCL2 altered in cohorts of …ALTERED_INderived4 of 4
→ altered in cohorts of	Pancreatic Adenocarcinoma 110 / 185 cases (59 %) · ssm · TCGA-PAAD	—	—	Pancreatic Adenocarcinoma	1	Observed	gdc	graph →
→ altered in cohorts of	Diffuse Large B-Cell Lymphomahematologic_malignancy 21 / 50 cases (42 %) · ssm · TCGA-DLBC	—	—	Diffuse Large B-Cell Lymphoma	1	Observed	gdc	graph →
→ altered in cohorts of	B-Cell Non-Hodgkin Lymphoma 153 / 755 cases (20 %) · ssm · mbn_mdacc_2013 · largest of 2 cohorts	—	—	B-Cell Non-Hodgkin Lymphoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Diffuse Large B-Cell Lymphoma Unclassifiable 101 / 1,001 cases (10 %) · ssm · dlbcl_duke_2017 · largest of 2 cohorts	—	—	Diffuse Large B-Cell Lymphoma Unclassifiable	2	Observed	cbioportal	graph →

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