Variant · Fusion
BCL2 reg_e@[IGH]::BCL2
CI-VAR-00005046Explore in graph →CIViC 151
Curated evidence
Evidence by cancer (2 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 12075054
- Run
- ING-CIVIC-20260908-000001
| Molecular profile | Therapy | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| Diffuse Large B-Cell Lymphoma1 | ||||||||
| BCL2 reg_e@[IGH]::BCL2 | (diagnostic) | Diagnostic | B | Supports Positive | 4 | accepted | EID407The t(14;18) transloaction of BCL2 is shown to be associated with germinal-center B-cell–like diffuse large-B-cell lymphomas. PMID 12075054 · Rosenwald et al., 2002 · Open in CIViC | civic |
| Follicular Lymphoma1 | ||||||||
| BCL2 reg_e@[IGH]::BCL2 | (diagnostic) | Diagnostic | B | Supports Positive | 5 | submitted | EID11808This translocation is a hallmark feature of follicular lymphoma. Although it is not present in every case, it is one of the most common genetic features of FL. FISH or IHC staining for BCL2 is part of… (full text at CIViC) PMID 3537802 · Yunis et al., 1987 · Open in CIViC | |
ClinVar
Clinical significance (0)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
Data not yet available