ATM

ATM serine/threonine kinase

Identifier: CI-GENE-00021243
Entity page: /gene/ATM ↗
Edges: 18,862

Neighbours: 32 cancers15 variants
Drawn: 47 of 47 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
ATM associated with …ASSOCIATED_WITH13 of 13
→ associated with	Castration-Resistant Prostate Carcinomasubtype	supports	A	Castration-Resistant Prostate Carcinoma	1	Curated	civic	graph →
→ associated with	Chronic Lymphocytic Leukemiahematologic_malignancy	supports

ATM has variant …HAS_VARIANTderived15 of 18,827show all (up to 200)
→ has variant	Mutationother 10 accepted CIViC evidence items	—	—	Hematopoietic and Lymphoid Cell Neoplasm,Melanoma,Glioblastoma+2	10	Curated	civic	graph →
→ has variant	Underexpressionexpression 5 accepted CIViC evidence items	—	—	Malignant Neoplasm,Malignant Gastric Neoplasm,Malignant Pancreatic Neoplasm+2	5	Curated	civic	graph →
→ has variant	A2062VSNV 1 accepted CIViC evidence items	—	—	Chronic Lymphocytic Leukemia	1	Curated	civic	graph →
→ has variant	C2488YSNV 1 accepted CIViC evidence items	—	—	Chronic Lymphocytic Leukemia	1	Curated	civic	graph →
→ has variant	c.7089+1del 1 accepted CIViC evidence items	—	—	Chronic Lymphocytic Leukemia	1	Curated	civic	graph →
→ has variant	c.7515+1_2del 1 accepted CIViC evidence items	—	—	Chronic Lymphocytic Leukemia	1	Curated	civic	graph →
→ has variant	c.902-1G>TSNV 1 accepted CIViC evidence items	—	—	Chronic Lymphocytic Leukemia	1	Curated	civic	graph →
→ has variant	D1682HSNV 1 accepted CIViC evidence items	—	—	Chronic Lymphocytic Leukemia	1	Curated	civic	graph →
→ has variant	D1930VSNV 1 accepted CIViC evidence items	—	—	Chronic Lymphocytic Leukemia	1	Curated	civic	graph →
→ has variant	E2187*SNV 1 accepted CIViC evidence items	—	—	Chronic Lymphocytic Leukemia	1	Curated	civic	graph →
→ has variant	F1025LSNV 1 accepted CIViC evidence items	—	—	Chronic Lymphocytic Leukemia	1	Curated	civic	graph →
→ has variant	F2732VSNV 1 accepted CIViC evidence items	—	—	Chronic Lymphocytic Leukemia	1	Curated	civic	graph →
→ has variant	K293*SNV 1 accepted CIViC evidence items	—	—	Chronic Lymphocytic Leukemia	1	Curated	civic	graph →
→ has variant	K468FSindel 1 accepted CIViC evidence items	—	—	Chronic Lymphocytic Leukemia	1	Curated	civic	graph →
→ has variant	L2427PSNV 1 accepted CIViC evidence items	—	—	Chronic Lymphocytic Leukemia	1	Curated	civic	graph →

ATM has variant …HAS_VARIANTderived15 of 18,827show all (up to 200)

→ has variant

Mutationother

10 accepted CIViC evidence items

—

Hematopoietic and Lymphoid Cell Neoplasm,Melanoma,Glioblastoma+2

Curated

ATM altered in cohorts of …ALTERED_INderived22 of 22show fewer
→ altered in cohorts of	Skin Basal Cell Carcinoma 55 / 293 cases (19 %) · ssm · bcc_unige_2016	—	—	Skin Basal Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	B-Cell Non-Hodgkin Lymphoma 116 / 755 cases (15 %) · ssm · mbn_mdacc_2013	—	—	B-Cell Non-Hodgkin Lymphoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Invasive Breast Carcinoma 69 / 527 cases (13 %) · ssm · brca_msk_2025	—	—	Invasive Breast Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Colon Adenocarcinoma 55 / 429 cases (13 %) · ssm · coad_tcga_gdc · largest of 2 cohorts	—	—	Colon Adenocarcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Endometrial Endometrioid Adenocarcinoma 31 / 247 cases (13 %) · ssm · uec_cptac_gdc	—	—	Endometrial Endometrioid Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Bladder Urothelial Carcinoma 58 / 474 cases (12 %) · ssm · blca_msk_tcga_2020 · largest of 8 cohorts	—	—	Bladder Urothelial Carcinoma	8	Observed	cbioportal	graph →
→ altered in cohorts of	Esophageal Adenocarcinoma 21 / 185 cases (11 %) · ssm · esca_tcga	—	—	Esophageal Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Gastroesophageal Junction Adenocarcinoma 56 / 518 cases (11 %) · ssm · stes_tcga_pub	—	—	Gastroesophageal Junction Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Small Lymphocytic Lymphoma 111 / 1,075 cases (10 %) · ssm · cll_broad_2022 · largest of 3 cohorts	—	—	Small Lymphocytic Lymphoma	3	Observed	cbioportal	graph →
→ altered in cohorts of	Cutaneous Melanoma 71 / 696 cases (10 %) · ssm · mel_mskimpact_2020	—	—	Cutaneous Melanoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Adenocarcinoma 258 / 2,653 cases (9.7 %) · ssm · luad_mskcc_2023_met_organotropism · largest of 7 cohorts	—	—	Lung Adenocarcinoma	7	Observed	cbioportal	graph →
→ altered in cohorts of	Rectal Adenocarcinoma 646 / 7,237 cases (8.9 %) · ssm · crc_msk_2026	—	—	Rectal Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Gastric Adenocarcinomasubtype 39 / 478 cases (8.2 %) · ssm · stad_tcga · largest of 4 cohorts	—	—	Gastric Adenocarcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Colorectal Adenocarcinoma 85 / 1,134 cases (7.5 %) · ssm · crc_msk_2017 · largest of 7 cohorts	—	—	Colorectal Adenocarcinoma	7	Observed	cbioportal	graph →
→ altered in cohorts of	Endometrial Carcinoma 139 / 1,882 cases (7.4 %) · ssm · ucec_ancestry_cds_msk_2023 · largest of 7 cohorts	—	—	Endometrial Carcinoma	7	Observed	cbioportal	graph →
→ altered in cohorts of	Diffuse Large B-Cell Lymphoma Unclassifiable 72 / 1,001 cases (7.2 %) · ssm · dlbcl_duke_2017	—	—	Diffuse Large B-Cell Lymphoma Unclassifiable	1	Observed	cbioportal	graph →
→ altered in cohorts of	Prostate Adenocarcinoma 27 / 444 cases (6.1 %) · ssm · prad_su2c_2019 · largest of 2 cohorts	—	—	Prostate Adenocarcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Non-Small Cell Carcinoma 71 / 1,257 cases (5.6 %) · ssm · nsclc_ctdx_msk_2022 · largest of 2 cohorts	—	—	Lung Non-Small Cell Carcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Adenoid Cystic Carcinoma 59 / 1,049 cases (5.6 %) · ssm · acc_2019	—	—	Adenoid Cystic Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Pancreatic Adenocarcinoma 23 / 412 cases (5.6 %) · ssm · pancreas_ctdna_msk_2025	—	—	Pancreatic Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Cholangiocarcinoma 23 / 417 cases (5.5 %) · ssm · chol_icgc_2017	—	—	Cholangiocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Hepatocellular Carcinoma 74 / 1,370 cases (5.4 %) · ssm · hcc_msk_2024	—	—	Hepatocellular Carcinoma	1	Observed	cbioportal	graph →

Radial view

Every edge, grouped by relationship

Paths