Tucatinib

small molecule

Identifier: CI-DRUG-00000615
Entity page: /drug/tucatinib ↗
Edges: 114

Neighbours: 21 cancers1 genes10 trials4 approvals
Drawn: 36 of 36 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Tucatinib approved for …APPROVED_FOR8 of 4
→ approved for	Malignant Colorectal Neoplasmsubtype	supports	FDA ORIG	Malignant Colorectal Neoplasm	1	Regulatory	openfda	graph →
→ approved for	HER2-Positive Breast Carcinomamolecular_subtype	supports

Tucatinib targets …TARGETS1 of 1
→ targets	ERBB2	—	INHIBITOR	—	1	Curated	chembl	graph →

Tucatinib targets …TARGETS1 of 1

→ targets

ERBB2

—

INHIBITOR

—

Curated

Tucatinib investigated for …INVESTIGATED_FOR10 of 10
→ investigated for	Colorectal Neoplasmsubtype	unknown	4	Colorectal Neoplasm	1	Curated	chembl	graph →
→ investigated for	Neoplasmcancer_family	unknown	4	Neoplasm	1	Curated	chembl	graph →
→ investigated for	Breast Neoplasmcancer_family	unknown	4	Breast Neoplasm	1	Curated	chembl	graph →
→ investigated for	Colon Neoplasmsubtype	unknown	2	Colon Neoplasm	1	Curated	chembl	graph →
→ investigated for	Gastric Neoplasmcancer_family	unknown	2	Gastric Neoplasm	1	Curated	chembl	graph →
→ investigated for	Angiosarcomasubtype	unknown	2	Angiosarcoma	1	Curated	chembl	graph →
→ investigated for	Lung Neoplasmcancer_family	unknown	1	Lung Neoplasm	1	Curated	chembl	graph →
→ investigated for	Hepatocellular Carcinomasubtype	unknown	1	Hepatocellular Carcinoma	1	Curated	chembl	graph →
→ investigated for	Lung Non-Small Cell Carcinomasubtype	unknown	1	Lung Non-Small Cell Carcinoma	1	Curated	chembl	graph →
→ investigated for	Chronic Myeloid Leukemia, BCR-ABL1 Positivemolecular_subtype	unknown	1	Chronic Myeloid Leukemia, BCR-ABL1 Positive	1	Curated	chembl	graph →

Tucatinib investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 44show all (up to 200)
→ investigated in trials for	Malignant Breast Neoplasmcancer_family 20 trials (14 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Breast Neoplasm	20	Observed	clinicaltrials	graph →
→ investigated in trials for	HER2-Positive Breast Carcinomamolecular_subtype 19 trials (9 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	HER2-Positive Breast Carcinoma	19	Observed	clinicaltrials	graph →
→ investigated in trials for	Breast Neoplasmcancer_family 8 trials (5 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Breast Neoplasm	8	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Colorectal Neoplasmsubtype 4 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Colorectal Neoplasm	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Solid Neoplasm 4 trials (4 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Solid Neoplasm	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Colorectal Neoplasmsubtype 3 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Colorectal Neoplasm	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Lung Non-Small Cell Carcinomasubtype 3 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Lung Non-Small Cell Carcinoma	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Colon Neoplasm 3 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Colon Neoplasm	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Rectal Neoplasm 3 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Rectal Neoplasm	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Colon Adenocarcinoma 2 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Colon Adenocarcinoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Colon Neoplasmsubtype 2 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Colon Neoplasm	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Colorectal Adenocarcinoma 2 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Colorectal Adenocarcinoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Esophageal Adenocarcinoma 2 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Esophageal Adenocarcinoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Gastric Adenocarcinoma 2 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Gastric Adenocarcinoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Gastroesophageal Junction Adenocarcinoma 2 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Gastroesophageal Junction Adenocarcinoma	2	Observed	clinicaltrials	graph →

Tucatinib studied in …STUDIED_INderived10 of 55show all (up to 200)
→ studied in	NCT04721977Phase 2 · active not recruiting A Study of Tucatinib (MK-7119) in Combination With Trastuzumab and Capecitabine in Participants With Previously Treated Locally Advanced Unresectable or Metastatic Human Epidermal Growth Factor Receptor 2 Positive (HER2+) Breast Carcinoma (MK-7119-001) · 55 trials list this drug (33 active)	—	—	Malignant Breast Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT07413939Phase 2/Phase 3 · recruiting RO7771950 Versus Tucatinib in Combination With Trastuzumab and Capecitabine in People With Locally Advanced or Metastatic Breast Cancer That is Human Epidermal Growth Factor Receptor 2 (HER2)-Positive · 55 trials list this drug (33 active)	—	—	HER2-Positive Breast Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT05868226Phase 1/Phase 2 · recruiting PRE-ISPY Phase I/II Oncology Platform Program · 55 trials list this drug (33 active)	—	—	Neoplasm,Malignant Neoplasm,Solid Neoplasm+2	1	Observed	clinicaltrials	graph →
→ studied in	NCT07768358Phase 4 · not yet recruiting Tucatinib Continuation Study · 55 trials list this drug (33 active)	—	—	Lung Non-Small Cell Carcinoma,Malignant Colorectal Neoplasm,HER2-Positive Breast Carcinoma+1	1	Observed	clinicaltrials	graph →
→ studied in	NCT04579380Phase 2 · active not recruiting Basket Study of Tucatinib and Trastuzumab in Solid Tumors With HER2 Alterations · 55 trials list this drug (33 active)	—	—	Urinary Tract Neoplasm,Lung Non-Small Cell Carcinoma,Uterine Neoplasm+1	1	Observed	clinicaltrials	graph →
→ studied in	NCT06439693Phase 2 · recruiting The SAPPHO Study: Sequential Therapy With Curative Intent in de Novo HER2+ Metastatic Breast Cancer · 55 trials list this drug (33 active)	—	—	Malignant Breast Neoplasm,HER2-Positive Breast Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT03975647Phase 3 · active not recruiting A Study of Tucatinib vs. Placebo in Combination With Ado-trastuzumab Emtansine (T-DM1) for Patients With Advanced or Metastatic HER2+ Breast Cancer · 55 trials list this drug (33 active)	—	—	HER2-Positive Breast Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT05132582Phase 3 · active not recruiting A Study of Tucatinib or Placebo With Trastuzumab and Pertuzumab for Metastatic HER2+ Breast Cancer · 55 trials list this drug (33 active)	—	—	HER2-Positive Breast Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT05253651Phase 3 · recruiting A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer · 55 trials list this drug (33 active)	—	—	Colorectal Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT06157892Phase 2 · active not recruiting A Study of Disitamab Vedotin With Other Anticancer Drugs in Solid Tumors · 55 trials list this drug (33 active)	—	—	Breast Neoplasm,Gastric Neoplasm,Malignant Breast Neoplasm+2	1	Observed	clinicaltrials	graph →

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