Sotrastaurin Acetate

small molecule

Identifier: CI-DRUG-00000559
Entity page: /drug/sotrastaurin-acetate ↗
Edges: 29

Neighbours: 7 cancers11 genes2 variants7 trials
Drawn: 27 of 27 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Sotrastaurin Acetate predicts response to …PREDICTS_RESPONSE_TO2 of 2
← predicts response to	GNA11 Mutationother	sensitivity	D	Uveal Melanoma	1	Curated	civic	graph →
← predicts response to	GNAQ Mutationother	sensitivity	D

Sotrastaurin Acetate targets …TARGETS11 of 11
→ targets	PRKCQ	—	INHIBITOR	—	1	Curated	chembl	graph →
→ targets	PRKCH	—	INHIBITOR	—	1	Curated	chembl	graph →
→ targets	PRKD1	—	INHIBITOR	—	1	Curated	chembl	graph →
→ targets	PRKCE	—	INHIBITOR	—	1	Curated	chembl	graph →
→ targets	PRKCB	—	INHIBITOR	—	1	Curated	chembl	graph →
→ targets	PRKCZ	—	INHIBITOR	—	1	Curated	chembl	graph →
→ targets	PRKCD	—	INHIBITOR	—	1	Curated	chembl	graph →
→ targets	PRKCG	—	INHIBITOR	—	1	Curated	chembl	graph →
→ targets	PRKCA	—	INHIBITOR	—	1	Curated	chembl	graph →
→ targets	PRKCI	—	INHIBITOR	—	1	Curated	chembl	graph →
→ targets	PRKD3	—	INHIBITOR	—	1	Curated	chembl	graph →

Sotrastaurin Acetate targets …TARGETS11 of 11

→ targets

PRKCQ

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INHIBITOR

—

Curated

Sotrastaurin Acetate investigated for …INVESTIGATED_FOR3 of 3
→ investigated for	Uveal Melanomasubtype 2 source records aggregated	supports	D	Uveal Melanoma	2	Curated	civic	graph →
→ investigated for	Lymphomacancer_family	unknown	1	Lymphoma	1	Curated	chembl	graph →
→ investigated for	Uveal Melanomasubtype	unknown	1	Uveal Melanoma	1	Curated	chembl	graph →

Sotrastaurin Acetate investigated in trials for …INVESTIGATED_IN_TRIALSderived6 of 6
→ investigated in trials for	Uveal Melanomasubtype 3 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Uveal Melanoma	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Chronic Lymphocytic Leukemia 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Chronic Lymphocytic Leukemia	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Diffuse Large B-Cell Lymphoma 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Diffuse Large B-Cell Lymphoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Mantle Cell Lymphoma 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Mantle Cell Lymphoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Prolymphocytic Leukemia 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Prolymphocytic Leukemia	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Small Lymphocytic Lymphoma 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Small Lymphocytic Lymphoma	1	Observed	clinicaltrials	graph →

Sotrastaurin Acetate studied in …STUDIED_INderived7 of 7
→ studied in	NCT02273219Phase 1 · completed Trial of AEB071 in Combination With BYL719 in Patients With Melanoma · 7 trials list this drug (0 active)	—	—	Uveal Melanoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT00885196Phase 2 · completed A Dose Finding Study of AEB071 Assessing Psoriasis Area and Severity Index in Patients With Plaque Psoriasis · 7 trials list this drug (0 active)	—	—	not mapped	1	Observed	clinicaltrials	graph →
→ studied in	NCT01402440Phase 1 · terminated Study of AEB071 (a Protein Kinase C Inhibitor) in Patients With CD79-mutant Diffuse Large B-Cell Lymphoma · 7 trials list this drug (0 active)	—	—	Diffuse Large B-Cell Lymphoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT01430416Phase 1 · completed Safety and Efficacy of AEB071 in Metastatic Uveal Melanoma Patients · 7 trials list this drug (0 active)	—	—	Uveal Melanoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT01854606Phase 1 · completed Safety and Efficacy of AEB071 and EVEROLIMUS in Patients With CD79-mutant or ABC Subtype Diffuse Large B-Cell Lymphoma · 7 trials list this drug (0 active)	—	—	not mapped	1	Observed	clinicaltrials	graph →
→ studied in	NCT01801358Phase 1/Phase 2 · terminated A Phase Ib/II Study of AEB071 and MEK162 in Adult Patients With Metastatic Uveal Melanoma · 7 trials list this drug (0 active)	—	—	Uveal Melanoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT02285244Phase 2 · withdrawn Sotrastaurin Acetate in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia, Small Lymphocytic Leukemia, Prolymphocytic Leukemia, or Richter's Transformation · 7 trials list this drug (0 active)	—	—	Chronic Lymphocytic Leukemia,Prolymphocytic Leukemia,Small Lymphocytic Lymphoma+1	1	Observed	clinicaltrials	graph →

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