PRKCB — gene · CancerIndex

Curated evidence

Clinical evidence (3)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–3 of 3 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
PRKCB D427N1
(diagnostic)	Adult T-Cell Leukemia/Lymphoma	Diagnostic	D	Supports Positive	3	accepted	EID6654 PRKCB was mutated in 33% of ATLL cases. 93% of these mutations were within the catalytic domain at Asp427. This gene has not been reported to be significantly mutated in any other cancers. Indeed thi… (full text at CIViC) PMID 26437031 · Kataoka et al., 2015 · Open in CIViC	civic
PRKCB Mutation2
(prognostic)	Adult T-Cell Leukemia/Lymphoma	Prognostic	D	Supports Poor Outcome	3	submitted	EID11794 For aggressive adult T cell leukemia/lymphoma (ATL), PRKCB mutations were associated with an adverse outcome (Hard Ratio: 2.07; 95% CI: 1.29-3.31; P-value: 0.003). In this study, 414 ATL patients were… (full text at CIViC) PMID ·

Cohorts

Alteration frequency by cohort (6)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved6 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Pancreatic Neuroendocrine Tumors (Johns Hopkins University, Science 2011) panet_jhu_2011	Pancreatic Neuroendocrine Tumor	Ssm

Literature

Linked publications (1)

25 per page, newest first.

pubmedPublishedShowing 1–1 of 1 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Integrated molecular analysis of adult T cell leukemia/lymphoma.
· Nat Genet · 2015 · PMID 26437031 · validated civic_curation pubmed