| Selumetinib studied in …STUDIED_INderived116 of 116show fewer |
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| → studied in | NCT05564377Phase 2 · recruiting Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial · 116 trials list this drug (32 active) | — | — | Malignant Solid Neoplasm,Primary Peritoneal Carcinoma,Malignant Female Reproductive System Neoplasm+2 | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01362803Phase 1/Phase 2 · active not recruiting AZD6244 Hydrogen Sulfate for Children With Nervous System Tumors · 116 trials list this drug (32 active) | — | — | Plexiform Neurofibroma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT07619521Phase 1/Phase 2 · recruiting Testing the Combination of Anti-Cancer Drugs, Selumetinib and DS-8201a (Trastuzumab Deruxtecan), for Advanced Pancreatic Ductal Adenocarcinoma · 116 trials list this drug (32 active) | — | — | Malignant Pancreatic Neoplasm,Pancreatic Ductal Adenocarcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01089101Phase 1/Phase 2 · active not recruiting Selumetinib in Treating Young Patients With Recurrent or Refractory Low Grade Glioma · 116 trials list this drug (32 active) | — | — | Low Grade Glioma,Visual Pathway Glioma,Childhood Pilocytic Astrocytoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02407405Phase 2 · active not recruiting MEK 1/2 Inhibitor Selumetinib (AZD6244 Hydrogen Sulfate) in Adults With Neurofibromatosis Type 1 (NF1) and Inoperable Plexiform Neurofibromas · 116 trials list this drug (32 active) | — | — | not mapped | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT04166409Phase 3 · recruiting A Study of the Drugs Selumetinib vs. Carboplatin and Vincristine in Patients With Low-Grade Glioma · 116 trials list this drug (32 active) | — | — | Low Grade Glioma,Low Grade Astrocytoma,WHO Grade 1 Glioma+1 | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01364051Phase 1 · active not recruiting Cediranib Maleate and Selumetinib Sulfate in Treating Patients With Solid Malignancies · 116 trials list this drug (32 active) | — | — | Malignant Solid Neoplasm,Melanoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT00463814Phase 1 · active not recruiting AZD6244 (ARRY-142886) Solid Oral Dosage Formulation in Participants With Advanced Solid Malignancies · 116 trials list this drug (32 active) | — | — | Neoplasm,Malignant Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT06502171Phase 1 · recruiting Study of Cabozantinib With Selumetinib for Plexiform Neurofibromas · 116 trials list this drug (32 active) | — | — | Plexiform Neurofibroma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT05101148Phase 1 · active not recruiting Phase I Study to Assess the Effect of Food on the PK and Gastrointestinal Tolerability of Selumetinib in Adolescent Children With Neurofibromatosis Type 1 Related Plexiform Neurofibromas · 116 trials list this drug (32 active) | — | — | not mapped | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT04590235Phase 1 · active not recruiting A Study of Selumetinib in Chinese Paediatric and Adult Subjects With Neurofibromatosis Type 1 (NF1) and Inoperable Plexiform Neurofibromas (PN) · 116 trials list this drug (32 active) | — | — | Plexiform Neurofibroma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT03871257Phase 3 · active not recruiting A Study of the Drugs Selumetinib Versus Carboplatin/Vincristine in Patients With Neurofibromatosis and Low-Grade Glioma · 116 trials list this drug (32 active) | — | — | Low Grade Glioma,Visual Pathway Glioma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT03392246Phase 2 · active not recruiting A Phase 2 Study of Osimertinib in Combination With Selumetinib in EGFR Inhibitor naïve Advanced EGFR Mutant Lung Cancer · 116 trials list this drug (32 active) | — | — | Lung Non-Small Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT05554328Phase 2 · active not recruiting Testing the Use of the Combination of Selumetinib and Olaparib or Selumetinib Alone Targeted Treatment for RAS Pathway Mutant Recurrent or Persistent Ovarian and Endometrial Cancers, A ComboMATCH Treatment Trial · 116 trials list this drug (32 active) | — | — | Primary Peritoneal Carcinoma,Ovarian Carcinoma,Endometrial Carcinoma+1 | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT03581487Phase 1/Phase 2 · completed Durvalumab, Tremelimumab, and Selumetinib in Treating Participants With Recurrent or Stage IV Non-small Cell Lung Cancer · 116 trials list this drug (32 active) | — | — | Malignant Lung Neoplasm,Lung Non-Small Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT06735820Phase 1/Phase 2 · recruiting Early Phase Study Evaluating MEK and MDM2 Inhibition in Patients With NF1 and MPNST · 116 trials list this drug (32 active) | — | — | Atypical Neurofibromatous Neoplasm of Uncertain Biologic Potential,Malignant Peripheral Nerve Sheath Tumor | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT03155620Phase 2 · active not recruiting Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders (The Pediatric MATCH Screening Trial) · 116 trials list this drug (32 active) | — | — | Hepatoblastoma,Malignant Germ Cell Tumor,Malignant Solid Neoplasm+2 | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01933932Phase 3 · active not recruiting Assess Efficacy & Safety of Selumetinib in Combination With Docetaxel in Patients Receiving 2nd Line Treatment for v-Ki-ras2 Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) Positive NSCLC · 116 trials list this drug (32 active) | — | — | Lung Non-Small Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT07713745Phase 2 · not yet recruiting Platform Research for Innovative Medicines in NF2-SWN (PRIME-NF2) · 116 trials list this drug (32 active) | — | — | Meningioma,Vestibular Schwannoma,Ependymoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT07707947Phase 2 · not yet recruiting Selumetinib for NF2-Related Schwannomatosis · 116 trials list this drug (32 active) | — | — | Meningioma,Vestibular Schwannoma,Ependymoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02813135Phase 1/Phase 2 · recruiting European Proof-of-Concept Therapeutic Stratification Trial of Molecular Anomalies in Relapsed or Refractory Tumors · 116 trials list this drug (32 active) | — | — | Childhood Malignant Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT04576117Phase 3 · active not recruiting A Study to Compare Treatment With the Drug Selumetinib Alone Versus Selumetinib and Vinblastine in Patients With Recurrent or Progressive Low-Grade Glioma · 116 trials list this drug (32 active) | — | — | Low Grade Glioma,Low Grade Astrocytoma,WHO Grade 1 Glioma+1 | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02151084Phase 2 · active not recruiting A Study of Different Dosing Schedules of Selumetinib With Cisplatin/Gemcitabine (CIS/GEM) Versus CIS/GEM Alone in Biliary Cancer · 116 trials list this drug (32 active) | — | — | Biliary Tract Carcinoma,Gallbladder Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT06188741Phase 2 · recruiting Selumetinib for the Prevention of Plexiform Neurofibroma Growth in NF Type 1 · 116 trials list this drug (32 active) | — | — | Plexiform Neurofibroma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT00600496Phase 1 · completed A Phase I, Open-Label, Multi-center Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD6244 (ARRY-142886) · 116 trials list this drug (32 active) | — | — | Breast Neoplasm,Malignant Breast Neoplasm,Melanoma+2 | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT03433183Phase 2 · completed SARC031: MEK Inhibitor Selumetinib (AZD6244) in Combination With the mTOR Inhibitor Sirolimus for Patients With Malignant Peripheral Nerve Sheath Tumors · 116 trials list this drug (32 active) | — | — | Malignant Peripheral Nerve Sheath Tumor | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02664935Phase 2 · completed National Lung Matrix Trial: Multi-drug Phase II Trial in Non-Small Cell Lung Cancer · 116 trials list this drug (32 active) | — | — | Adenocarcinoma,Squamous Cell Carcinoma,Lung Non-Small Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT03162627Phase 1 · active not recruiting Selumetinib and Olaparib in Solid Tumors · 116 trials list this drug (32 active) | — | — | Malignant Breast Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT04924608Phase 3 · active not recruiting Efficacy and Safety of Selumetinib in Adults With NF1 Who Have Symptomatic, Inoperable Plexiform Neurofibromas · 116 trials list this drug (32 active) | — | — | Plexiform Neurofibroma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT03801369Phase 2 · terminated AMTEC IIT: Phase 2 Multiarm Study in TNBC · 116 trials list this drug (32 active) | — | — | Triple-Negative Breast Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02546661Phase 1 · active not recruiting Open-Label, Randomised, Multi-Drug, Biomarker-Directed, Phase 1b Study in Pts w/ Muscle Invasive Bladder Cancer · 116 trials list this drug (32 active) | — | — | not mapped | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT03326310Phase 1 · recruiting Selumetinib and Azacitidine in High Risk Chronic Blood Cancers · 116 trials list this drug (32 active) | — | — | Chronic Myeloid Leukemia, BCR-ABL1 Positive,Primary Myelofibrosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT03095248Phase 2 · terminated Trial of Selumetinib in Patients With Neurofibromatosis Type II Related Tumors · 116 trials list this drug (32 active) | — | — | Glioma,Meningioma,Vestibular Schwannoma+1 | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02188264Phase 1 · completed Selumetinib and Cyclosporine in Treating Patients With Advanced Solid Tumors or Advanced or Metastatic Colorectal Cancer · 116 trials list this drug (32 active) | — | — | Solid Neoplasm,Colorectal Carcinoma,Malignant Colorectal Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT03213691Phase 2 · completed Selumetinib Sulfate in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Activating MAPK Pathway Mutations (A Pediatric MATCH Treatment Trial) · 116 trials list this drug (32 active) | — | — | Malignant Solid Neoplasm,Childhood Central Nervous System Neoplasm,Non-Hodgkin Lymphoma+2 | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT03944772Phase 2 · active not recruiting Phase 2 Platform Study in Patients With Advanced Non-Small Lung Cancer Who Progressed on First-Line Osimertinib Therapy (ORCHARD) · 116 trials list this drug (32 active) | — | — | Lung Non-Small Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02299999Phase 2 · active not recruiting SAFIR02_Breast - Efficacy of Genome Analysis as a Therapeutic Decision Tool for Patients With Metastatic Breast Cancer · 116 trials list this drug (32 active) | — | — | Malignant Breast Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT06763315Phase 2 · not yet recruiting Low-dose Selumetinib for the Treatment of Plexiform Neurofibromas in Chinese Children · 116 trials list this drug (32 active) | — | — | not mapped | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT03833427Phase 1 · terminated Study of Selumetinib (MK-5618) in Combination With Pembrolizumab (MK-3475) in Participants With Advanced/Metastatic Solid Tumors (MK-5618-001) · 116 trials list this drug (32 active) | — | — | not mapped | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01306045Phase 2 · completed Molecular Profiling and Targeted Therapy for Advanced Non-Small Cell Lung Cancer, Small Cell Lung Cancer, and Thymic Malignancies · 116 trials list this drug (32 active) | — | — | Thymus Carcinoma,Lung Non-Small Cell Carcinoma,Lung Small Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT06620354Phase 2 · not yet recruiting Clinical Study on the Treatment of Type I Neurofibromatosis With Smeitinib Hydrosulfate Capsule · 116 trials list this drug (32 active) | — | — | not mapped | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT06621082Phase 2 · not yet recruiting The Clinical Study of the Treatment of Patients With Type I Neurofibromatosis With Smetinib Hydrosulfate Capsule · 116 trials list this drug (32 active) | — | — | not mapped | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02393690Phase 2 · completed Iodine I-131 With or Without Selumetinib in Treating Patients With Recurrent or Metastatic Thyroid Cancer · 116 trials list this drug (32 active) | — | — | Thyroid Gland Follicular Carcinoma,Thyroid Gland Carcinoma,Thyroid Gland Papillary Carcinoma+1 | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT03326388Phase 1/Phase 2 · completed Intermittent Dosing Of Selumetinib In Childhood NF1 Associated Tumours · 116 trials list this drug (32 active) | — | — | Optic Nerve Glioma,Plexiform Neurofibroma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02337530Phase 2 · completed Selumetinib in Patients Receiving Pemetrexed and Platinum-based Chemotherapy in Advanced or Metastatic KRAS Wildtype or Unknown Non-Squamous NSCLC · 116 trials list this drug (32 active) | — | — | Lung Non-Small Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02117167Phase 2 · completed SAFIR02_Lung - Efficacy of Targeted Drugs Guided by Genomic Profiles in Metastatic NSCLC Patients · 116 trials list this drug (32 active) | — | — | not mapped | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02839720Phase 2 · completed Selumetinib in Treating Patients With Neurofibromatosis Type 1 and Cutaneous Neurofibroma · 116 trials list this drug (32 active) | — | — | Optic Nerve Glioma,Skin Neurofibroma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01750281Phase 2 · completed Assess Efficacy and Safety of AZD6244 in Combination With Docetaxel in Patients Receiving Second Line Non Small Cell Lung Cancer Treatment. · 116 trials list this drug (32 active) | — | — | Lung Non-Small Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02768766Phase 1 · completed Intermittent Selumetinib for Uveal Melanoma · 116 trials list this drug (32 active) | — | — | Uveal Melanoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT05825365Phase 2 · withdrawn Selumetinib in Chinese Paediatric With Post-operative NF1-PNs, PhaseⅡ, Double-Blinded, Placebo-Controlled Study · 116 trials list this drug (32 active) | — | — | not mapped | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01783197Phase 1 · completed Study of Selumetinib in Patients With Previously Treated or Untreated Advanced/Metastatic NSCLC · 116 trials list this drug (32 active) | — | — | Lung Non-Small Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT03745989Phase 1 · completed Study of MK-8353 + Selumetinib in Advanced/Metastatic Solid Tumors (MK-8353-014) · 116 trials list this drug (32 active) | — | — | Solid Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT03705507Phase 1/Phase 2 · terminated International Trial of Selumetinib in Combination With Dexamethasone for the Treatment of Acute Lymphoblastic Leukaemia · 116 trials list this drug (32 active) | — | — | Acute Lymphoblastic Leukemia,Adult Acute Lymphoblastic Leukemia,Childhood Acute Lymphoblastic Leukemia | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT04495127Phase 1 · completed Selumetinib Paediatric NF1 Japan Study · 116 trials list this drug (32 active) | — | — | not mapped | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01160926Phase 1 · terminated Dual REctcal Angiogenesis or MEK Inhibition radioTHERAPY Trial · 116 trials list this drug (32 active) | — | — | Malignant Rectal Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02503358Phase 1 · completed Selumetinib and Paclitaxel as Second-Line Treatment in Treating Patients With Stage IIIB-IV Non-small Cell Lung Cancer · 116 trials list this drug (32 active) | — | — | Lung Non-Small Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01146756Phase 1 · completed MEK Inhibitor and Thoracic Radiotherapy Trial · 116 trials list this drug (32 active) | — | — | Lung Non-Small Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01248247Phase 2 · completed BATTLE-2 Program: A Biomarker-Integrated Targeted Therapy Study in Previously Treated Patients With Advanced Non-Small Cell Lung Cancer · 116 trials list this drug (32 active) | — | — | Malignant Lung Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01134601Phase 1 · terminated A Phase I Study of AZD6244 in Combination With Capecitabine and Radiotherapy in Locally Advanced Adenocarcinoma of the Rectum · 116 trials list this drug (32 active) | — | — | Rectal Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT03040986Phase 2 · completed Selumetinib Sulfate in Treating Patients With Locally Advanced or Metastatic Pancreatic Cancer With KRAS G12R Mutations · 116 trials list this drug (32 active) | — | — | not mapped | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT00551070Phase 2 · completed Selumetinib Sulfate in Treating Woman With Recurrent Low-Grade Ovarian Cancer or Peritoneum Cancer · 116 trials list this drug (32 active) | — | — | Borderline Ovarian Epithelial Tumor,Borderline Ovarian Serous Tumor,Primary Peritoneal Carcinoma+2 | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT00780676Phase 2 · terminated Personalized Treatment Selection for Metastatic Breast Cancer · 116 trials list this drug (32 active) | — | — | Malignant Breast Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01222689Phase 2 · completed Selumetinib and Erlotinib Hydrochloride in Treating Patients With Locally Advanced or Metastatic Pancreatic Cancer · 116 trials list this drug (32 active) | — | — | Malignant Pancreatic Neoplasm,Pancreatic Adenocarcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT03259633approved for marketing An Intermediate Access Protocol for Selumetinib for Treatment of Neurofibromatosis Type 1 · 116 trials list this drug (32 active) | — | — | not mapped | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02583542Phase 1/Phase 2 · unknown A Study of AZD2014 in Combination With Selumetinib in Patients With Advanced Cancers · 116 trials list this drug (32 active) | — | — | Lung Squamous Cell Carcinoma,Triple-Negative Breast Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01287130Phase 1 · completed AZD6244 With Cetuximab for Solid Tumors and Colorectal Cancer · 116 trials list this drug (32 active) | — | — | Colorectal Neoplasm,Colon Neoplasm,Malignant Colon Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02586987Phase 1 · completed A Study to Assess the Safety, Tolerability and Anti-tumour Activity of Ascending Doses of Selumetinib in Combination With MEDI4736 and Selumetinib in Combination With MEDI4736 and Tremelimumab in Patients With Advanced Solid Tumours · 116 trials list this drug (32 active) | — | — | Malignant Breast Neoplasm,Melanoma,Head and Neck Carcinoma+2 | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01843062Phase 3 · terminated Comparing Complete Remission After Treatment With Selumetinib/Placebo in Patient With Differentiated Thyroid Cancer · 116 trials list this drug (32 active) | — | — | not mapped | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01011933Phase 2 · completed Selumetinib in Treating Patients With Recurrent or Persistent Endometrial Cancer · 116 trials list this drug (32 active) | — | — | Endometrial Adenocarcinoma,Endometrial Adenosquamous Carcinoma,Endometrial Clear Cell Adenocarcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01160718Phase 2 · completed Fulvestrant With or Without AZD6244 in Treating Patients With Advanced Breast Cancer That Progressed After Aromatase Inhibitor Therapy · 116 trials list this drug (32 active) | — | — | Malignant Breast Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT03109301Phase 2 · withdrawn Mitogen Activated Protein Kinase Kinase (MEK1/2) Inhibitor Selumetinib (AZD6244 Hydrogen Sulfate) in People With Neurofibromatosis Type 1 (NF1) Mutated Gastrointestinal Stromal Tumors (GIST) · 116 trials list this drug (32 active) | — | — | Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01752569Phase 1/Phase 2 · terminated A Study of Selumetinib in Patients With Kaposi's Sarcoma · 116 trials list this drug (32 active) | — | — | AIDS-Related Kaposi Sarcoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02450656Phase 1/Phase 2 · unknown Afatinib and Selumetinib in Advanced KRAS Mutant and PIK3CA Wildtype Non-small Cell Lung Cancer · 116 trials list this drug (32 active) | — | — | Digestive System Neoplasm,Pancreatic Neoplasm,Colorectal Neoplasm+1 | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01021748Phase 1 · completed A Combination Therapy Study of MK-2206 and AZD6244 in Participants With Advanced Solid Tumors (MK-2206-010) · 116 trials list this drug (32 active) | — | — | not mapped | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02025114Phase 1/Phase 2 · completed Selumetinib in Combination With Gefitinib in NSCLC Patients · 116 trials list this drug (32 active) | — | — | Lung Non-Small Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT00890825Phase 2 · completed AZD6244 in Combination With Docetaxel Versus Docetaxel Alone in KRAS Mutation Positive NSCLC Patients · 116 trials list this drug (32 active) | — | — | Lung Non-Small Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT03004105Phase 2 · withdrawn MEDI4736 With Selumetinib for KRAS Mutant Non-Small Cell Lung Cancer (NSCLC) · 116 trials list this drug (32 active) | — | — | Malignant Lung Neoplasm,Lung Non-Small Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01809210Phase 1 · completed Assess Safety & Efficacy of Selumetinib When Given in Combination With Standard First Line Treatment for Advanced Non-small Cell Lung Cancer · 116 trials list this drug (32 active) | — | — | Lung Non-Small Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01143402Phase 2 · completed Temozolomide or Selumetinib in Treating Patients With Metastatic Melanoma of the Eye · 116 trials list this drug (32 active) | — | — | Uveal Melanoma,Iris Melanoma,Medium/Large Size Posterior Uveal Melanoma+2 | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01229150Phase 2 · completed Randomized Phase II Study of AZD6244 (Mitogen-activated Protein Kinase Inhibitor) MEK-Inhibitor With Erlotinib in KRAS Wild Type Advanced Non-Small Cell Lung Cancer (NSCLC) and a Randomized Phase II Study of AZD6244 With Erlotinib in Mutant KRAS Adva... · 116 trials list this drug (32 active) | — | — | Lung Non-Small Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT00970359NA · completed Reacquisition of Radioactive Iodine (RAI) Uptake of RAI-Refractory Metastatic Thyroid Cancers by Pretreatment With the Selective MEK Inhibitor AZD6244 · 116 trials list this drug (32 active) | — | — | Malignant Thyroid Gland Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT00559949Phase 2 · completed Selumetinib in Treating Patients With Papillary Thyroid Cancer That Did Not Respond to Radioactive Iodine · 116 trials list this drug (32 active) | — | — | Thyroid Gland Carcinoma,Thyroid Gland Papillary Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01974752Phase 3 · completed Selumetinib (AZD6244: ARRY-142886) (Hyd-Sulfate) in Metastatic Uveal Melanoma (SUMIT) · 116 trials list this drug (32 active) | — | — | Uveal Melanoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01605916Phase 1 · completed Investigate the Safety and Tolerability of AZD6244 Monotherapy or + Docetaxel in Japanese Patients With Advanced Solid Malignancies or Non-Small Cell Lung Cancer · 116 trials list this drug (32 active) | — | — | Neoplasm,Malignant Neoplasm,Lung Neoplasm+1 | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02063230Phase 1 · completed To Assess the Pharmacokinetics, Safety and Tolerability of Selumetinib in Patients With Hepatic Impairment and Healthy Subjects · 116 trials list this drug (32 active) | — | — | Solid Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01242605Phase 1 · completed ABC-04 a Study of Cisplatin, Gemcitabine and Selumetinib in Patients With Advanced Biliary Tract Cancer · 116 trials list this drug (32 active) | — | — | Gallbladder Neoplasm,Cholangiocarcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01949870Phase 1 · terminated Selumetinib (AZD6244, ARRY-142886) J-BTC Phase 1 Study · 116 trials list this drug (32 active) | — | — | not mapped | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT00553332Phase 2 · completed Selumetinib in Treating Patients With Biliary Cancer That Cannot Be Removed By Surgery · 116 trials list this drug (32 active) | — | — | Malignant Extrahepatic Bile Duct Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT00936221Phase 2 · completed Comparison of AZD6244 in Combination With Dacarbazine Versus (vs) Dacarbazine Alone in BRAF Mutation Positive Melanoma Patients · 116 trials list this drug (32 active) | — | — | Melanoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01658943Phase 2 · completed Selumetinib and Akt Inhibitor MK2206 or mFOLFOX Therapy Comprising Oxaliplatin and Fluorouracil in Treating Patients With Metastatic Pancreatic Cancer Previously Treated With Chemotherapy · 116 trials list this drug (32 active) | — | — | Malignant Pancreatic Neoplasm,Pancreatic Carcinoma,Pancreatic Acinar Cell Carcinoma+1 | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02685657Phase 2 · unknown Neoadjuvant Chemotherapy Docetaxel With or Without SELUMETINIB in Patients With Triple Negative Breast Cancer · 116 trials list this drug (32 active) | — | — | Triple-Negative Breast Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01278615Phase 2 · terminated Selumetinib in Treating Patients With Relapsed or Refractory Diffuse Large B-cell Lymphoma · 116 trials list this drug (32 active) | — | — | not mapped | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01061749Phase 1 · completed Selumetinib and Cixutumumab in Treating Patients With Advanced Solid Malignancies · 116 trials list this drug (32 active) | — | — | Adult Solid Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT00888134Phase 2 · completed Selumetinib in Cancers With BRAF Mutations · 116 trials list this drug (32 active) | — | — | Adult Solid Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02056392Phase 1 · completed To Assess the Effects of Single Oral Dose of Selumetinib [AZD6244; ARRY-142886] [Hyd-Sulfate]), on QTc Interval in Healthy Male Volunteers · 116 trials list this drug (32 active) | — | — | Solid Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01206140Phase 2 · completed Selumetinib With or Without Temsirolimus in Treating Patients With Metastatic, Recurrent, or Locally Advanced Soft Tissue Sarcoma That Cannot Be Removed By Surgery · 116 trials list this drug (32 active) | — | — | Adult Soft Tissue Sarcoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01085214Phase 2 · completed AZD6244 (Selumetinib) in Treating Patients With Multiple Myeloma · 116 trials list this drug (32 active) | — | — | Multiple Myeloma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT00866177Phase 2 · completed MEK Inhibitor AZD6244 in Treating Patients With Stage III or Stage IV Melanoma · 116 trials list this drug (32 active) | — | — | Melanoma,Cutaneous Melanoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT00588809Phase 2 · completed Selumetinib in Treating Patients With Recurrent or Refractory Acute Myeloid Leukemia · 116 trials list this drug (32 active) | — | — | Myelodysplastic Syndrome,Myelodysplastic/Myeloproliferative Neoplasm,Secondary Acute Myeloid Leukemia+2 | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01931761Phase 1 · completed Study Evaluating Absorption, Distribution, Metabolism and Excretion (ADME) of Single Dose [14C] Selumetinib in Volunteers · 116 trials list this drug (32 active) | — | — | Solid Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02063204Phase 1 · completed To Assess the Pharmacokinetics, Safety and Tolerability of Selumetinib in Renal Impaired Subjects and Healthy Subjects · 116 trials list this drug (32 active) | — | — | Solid Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02093728Phase 1 · completed To Assess the Effect of Itraconazole and Fluconazole on the Pharmacokinetics of Selumetinib in Healthy Male Volunteers · 116 trials list this drug (32 active) | — | — | Solid Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01859182Phase 2 · withdrawn Selumetinib and Akt Inhibitor MK-2206 in Treating Patients With Refractory or Advanced Gallbladder or Bile Duct Cancer That Cannot Be Removed By Surgery · 116 trials list this drug (32 active) | — | — | Malignant Gallbladder Neoplasm,Malignant Extrahepatic Bile Duct Neoplasm,Adult Cholangiocarcinoma+1 | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT00338130Phase 2 · completed Randomised Study to Compare the Efficacy of AZD6244 vs TMZ · 116 trials list this drug (32 active) | — | — | Melanoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT00372788Phase 2 · completed AZD6244 Versus Pemetrexed (Alimta®) in Patients With Non-small Cell Lung Cancer, Who Have Failed One or Two Prior Chemotherapy Regimen · 116 trials list this drug (32 active) | — | — | Lung Non-Small Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT00372944Phase 2 · completed AZD6244 vs. Capecitabine (Xeloda®) in Patients With Advanced or Metastatic Pancreatic Cancer, Who Have Failed First Line Gemcitabine Therapy · 116 trials list this drug (32 active) | — | — | Malignant Pancreatic Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT00514761Phase 2 · completed Phase II Efficacy Study of AZD6244 in Colorectal Cancer · 116 trials list this drug (32 active) | — | — | Malignant Colorectal Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT00710515Phase 1 · completed Study to Assess the Effect of Dosing AZD6244 HydSulfate in the Presence and Absence of Food in Patients With Advanced Solid Malignancies · 116 trials list this drug (32 active) | — | — | Melanoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01974349Phase 1 · completed To Assess the Effect of Food on the Pharmacokinetics of Selumetinib (AZD6244; ARRY-142886) (Hyd-Sulfate) in Healthy Male Volunteers · 116 trials list this drug (32 active) | — | — | Solid Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01519427Phase 2 · terminated Selumetinib and Akt Inhibitor MK2206 in Treating Patients With Stage III or Stage IV Melanoma Who Failed Prior Therapy With Vemurafenib or Dabrafenib · 116 trials list this drug (32 active) | — | — | Melanoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01960374Phase 1 · completed Dose-escalation Study to Assess Selumetinib Safety, Tolerability and PK · 116 trials list this drug (32 active) | — | — | not mapped | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01217450Phase 1 · completed Selumetinib and Cetuximab in Treating Patients With Refractory Solid Tumors · 116 trials list this drug (32 active) | — | — | Adult Solid Neoplasm,Malignant Colon Neoplasm,Malignant Rectal Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT00604721Phase 2 · completed Selumetinib in Treating Patients With Locally Advanced or Metastatic Liver Cancer · 116 trials list this drug (32 active) | — | — | Adult Hepatocellular Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01166126Phase 2 · terminated Temsirolimus/AZD 6244 for Treatment-naive With BRAF Mutant Unresectable Stage IV · 116 trials list this drug (32 active) | — | — | Melanoma,Mucosal Melanoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02046850Phase 1 · completed To Assess the Effect of Rifampicin on the Pharmacokinetics of Selumetinib in Healthy Male Volunteers · 116 trials list this drug (32 active) | — | — | Solid Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01116271Phase 2 · completed Study of Selumetinib (AZD6244)(ARRY-142886) in Combination With Irinotecan in Previously Treated Patients With Colorec · 116 trials list this drug (32 active) | — | — | Malignant Colorectal Neoplasm | 1 | Observed | clinicaltrials | graph → |