Pentostatin

small molecule

Identifier: CI-DRUG-00000685
Entity page: /drug/pentostatin ↗
Edges: 68

Neighbours: 19 cancers1 genes10 trials2 approvals
Drawn: 32 of 32 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Pentostatin approved for …APPROVED_FOR3 of 2
→ approved for	Hairy Cell Leukemiahematologic_malignancy	supports	FDA ORIG	Hairy Cell Leukemia	1	Regulatory	openfda	graph →
→ approved for	Health Canada · CA · 1993Marketed in Canada as NIPENT PWS 10MG/VIAL (DIN 02011247) under ATC L01XX08 PENTOSTATIN. Indications are not published in the Drug Product Database — see the Health Canada Product Monograph.

Pentostatin targets …TARGETS1 of 1
→ targets	ADA	—	INHIBITOR	—	1	Curated	chembl	graph →

Pentostatin targets …TARGETS1 of 1

→ targets

ADA

—

INHIBITOR

—

Curated

Pentostatin investigated for …INVESTIGATED_FOR7 of 7
→ investigated for	Hairy Cell Leukemiahematologic_malignancy	unknown	4	Hairy Cell Leukemia	1	Curated	chembl	graph →
→ investigated for	Neoplasmcancer_family	unknown	4	Neoplasm	1	Curated	chembl	graph →
→ investigated for	Chronic Lymphocytic Leukemiahematologic_malignancy	unknown	3	Chronic Lymphocytic Leukemia	1	Curated	chembl	graph →
→ investigated for	Leukemiacancer_family	unknown	2	Leukemia	1	Curated	chembl	graph →
→ investigated for	Lymphomacancer_family	unknown	2	Lymphoma	1	Curated	chembl	graph →
→ investigated for	B-Cell Malignant Neoplasmcancer_family	unknown	1	B-Cell Malignant Neoplasm	1	Curated	chembl	graph →
→ investigated for	Kidney Neoplasmsubtype	unknown	1	Kidney Neoplasm	1	Curated	chembl	graph →

Pentostatin investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 25show all (up to 200)
→ investigated in trials for	Leukemiacancer_family 15 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Leukemia	15	Observed	clinicaltrials	graph →
→ investigated in trials for	Lymphomacancer_family 14 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Lymphoma	14	Observed	clinicaltrials	graph →
→ investigated in trials for	Chronic Lymphocytic Leukemiahematologic_malignancy 7 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Chronic Lymphocytic Leukemia	7	Observed	clinicaltrials	graph →
→ investigated in trials for	Hodgkin Lymphoma 4 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Hodgkin Lymphoma	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Myelodysplastic Syndrome 4 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Myelodysplastic Syndrome	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Acute Lymphoblastic Leukemia 3 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Acute Lymphoblastic Leukemia	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Acute Myeloid Leukemia 3 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Acute Myeloid Leukemia	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Hematopoietic and Lymphoid Cell Neoplasm 3 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Hematopoietic and Lymphoid Cell Neoplasm	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Multiple Myeloma 3 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Multiple Myeloma	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Chronic Myeloid Leukemia, BCR-ABL1 Positive 2 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Chronic Myeloid Leukemia, BCR-ABL1 Positive	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Myelodysplastic/Myeloproliferative Neoplasm 2 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Myelodysplastic/Myeloproliferative Neoplasm	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Non-Hodgkin Lymphoma 2 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Non-Hodgkin Lymphoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Peripheral T-Cell Lymphoma, Not Otherwise Specified 2 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Peripheral T-Cell Lymphoma, Not Otherwise Specified	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Renal Cell Carcinoma 2 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Renal Cell Carcinoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	B-Cell Non-Hodgkin Lymphoma 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	B-Cell Non-Hodgkin Lymphoma	1	Observed	clinicaltrials	graph →

Pentostatin studied in …STUDIED_INderived10 of 33show all (up to 200)
→ studied in	NCT01059786Phase 2 · active not recruiting Randomized Phase II Trial of Rituximab With Either Pentostatin or Bendamustine for Multiply Relapsed or Refractory Hairy Cell Leukemia · 33 trials list this drug (1 active)	—	—	Hairy Cell Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT01352312Phase 1 · terminated Combination of Pentostatin, Bendamustine and Ofatumumab for Treatment of Chronic Lymphocytic Leukemia and Lymphoma · 33 trials list this drug (1 active)	—	—	B-Cell Non-Hodgkin Lymphoma,Chronic Lymphocytic Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT00571662Phase 2 · completed Safety and Efficacy of Pentostatin and Low Dose TBI With Allogenic Peripheral Blood Stem Cell Transplant · 33 trials list this drug (1 active)	—	—	Acute Lymphoblastic Leukemia,Hodgkin Lymphoma,Multiple Myeloma+2	1	Observed	clinicaltrials	graph →
→ studied in	NCT00816413Phase 1/Phase 2 · withdrawn Donor Stem Cell Transplant, Pentostatin, and Total-Body Irradiation in Treating Patients With Hematological Cancer · 33 trials list this drug (1 active)	—	—	Leukemia,Lymphoma,Myelodysplastic Syndrome+1	1	Observed	clinicaltrials	graph →
→ studied in	NCT00074282Phase 2 · completed Pentostatin, Cyclophosphamide, and Rituximab Followed By Campath-1H in Patients With Relapsed or Refractory B-Cell CLL · 33 trials list this drug (1 active)	—	—	Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT00045305Phase 2 · completed Reduced-Intensity Regimen Before Donor Bone Marrow Transplant in Treating Patients With Myelodysplastic Syndromes · 33 trials list this drug (1 active)	—	—	Leukemia,Myelodysplastic Syndrome,Myelodysplastic/Myeloproliferative Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT00057954Phase 2 · terminated Reduced-Intensity Regimen Before Allogeneic Transplant for Patients With Relapsed Non-Hodgkin's or Hodgkin's Lymphoma · 33 trials list this drug (1 active)	—	—	Lymphoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT00496873Phase 2 · completed Evaluation of the Safety and Efficacy of Nipent, Cytoxan, and Rituxan · 33 trials list this drug (1 active)	—	—	Lymphoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT00096161Phase 2 · completed Pentostatin and Lymphocyte Infusion in Preventing Graft Rejection in Patients Who Have Undergone Donor Stem Cell Transplant · 33 trials list this drug (1 active)	—	—	Acute Lymphoblastic Leukemia,Hodgkin Lymphoma,Multiple Myeloma+2	1	Observed	clinicaltrials	graph →
→ studied in	NCT00602836Phase 2 · completed Rituximab, Pentostatin, Cyclophosphamide, and Lenalidomide in Treating Patients With Previously Untreated B-Cell Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma · 33 trials list this drug (1 active)	—	—	Leukemia,Lymphoma	1	Observed	clinicaltrials	graph →

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