Pegaspargase

other

Identifier: CI-DRUG-00000698
Entity page: /drug/pegaspargase ↗
Edges: 177

Neighbours: 19 cancers10 trials4 approvals
Drawn: 33 of 33 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Pegaspargase approved for …APPROVED_FOR6 of 4
→ approved for	Acute Lymphoblastic Leukemiahematologic_malignancy	supports	FDA ORIG	Acute Lymphoblastic Leukemia	1	Regulatory	openfda	graph →
→ approved for	Acute Lymphoblastic Leukemiahematologic_malignancy	supports

Pegaspargase investigated for …INVESTIGATED_FOR8 of 8
→ investigated for	Acute Lymphoblastic Leukemiahematologic_malignancy	unknown	4	Acute Lymphoblastic Leukemia	1	Curated	chembl	graph →
→ investigated for	Neoplasmcancer_family	unknown	4	Neoplasm	1	Curated	chembl	graph →
→ investigated for	Lymphoid Leukemiahematologic_malignancy	unknown	3	Lymphoid Leukemia	1	Curated	chembl	graph →
→ investigated for	T Acute Lymphoblastic Leukemiahematologic_malignancy	unknown	3	T Acute Lymphoblastic Leukemia	1	Curated	chembl	graph →
→ investigated for	Lymphomacancer_family	unknown	3	Lymphoma	1	Curated	chembl	graph →
→ investigated for	Leukemiacancer_family	unknown	3	Leukemia	1	Curated	chembl	graph →
→ investigated for	Acute Biphenotypic Leukemiahematologic_malignancy	unknown	3	Acute Biphenotypic Leukemia	1	Curated	chembl	graph →
→ investigated for	Acute Myeloid Leukemiahematologic_malignancy	unknown	2	Acute Myeloid Leukemia	1	Curated	chembl	graph →

Pegaspargase investigated for …INVESTIGATED_FOR8 of 8

→ investigated for

Acute Lymphoblastic Leukemiahematologic_malignancy

unknown

Acute Lymphoblastic Leukemia

Curated

Pegaspargase investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 39show all (up to 200)
→ investigated in trials for	Acute Lymphoblastic Leukemiahematologic_malignancy 46 trials (12 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Acute Lymphoblastic Leukemia	46	Observed	clinicaltrials	graph →
→ investigated in trials for	Leukemiacancer_family 30 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Leukemia	30	Observed	clinicaltrials	graph →
→ investigated in trials for	B Acute Lymphoblastic Leukemia 15 trials (10 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	B Acute Lymphoblastic Leukemia	15	Observed	clinicaltrials	graph →
→ investigated in trials for	Childhood Acute Lymphoblastic Leukemia 10 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Childhood Acute Lymphoblastic Leukemia	10	Observed	clinicaltrials	graph →
→ investigated in trials for	Lymphoblastic Lymphoma 10 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Lymphoblastic Lymphoma	10	Observed	clinicaltrials	graph →
→ investigated in trials for	Nasal Type Extranodal NK/T-Cell Lymphoma 10 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Nasal Type Extranodal NK/T-Cell Lymphoma	10	Observed	clinicaltrials	graph →
→ investigated in trials for	Childhood B Acute Lymphoblastic Leukemia 9 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Childhood B Acute Lymphoblastic Leukemia	9	Observed	clinicaltrials	graph →
→ investigated in trials for	T Acute Lymphoblastic Leukemiahematologic_malignancy 9 trials (4 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	T Acute Lymphoblastic Leukemia	9	Observed	clinicaltrials	graph →
→ investigated in trials for	Childhood T Acute Lymphoblastic Leukemia 6 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Childhood T Acute Lymphoblastic Leukemia	6	Observed	clinicaltrials	graph →
→ investigated in trials for	Adult B Acute Lymphoblastic Leukemia 5 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Adult B Acute Lymphoblastic Leukemia	5	Observed	clinicaltrials	graph →
→ investigated in trials for	Extranodal NK-/T-Cell Lymphoma, Nasal Type 5 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Extranodal NK-/T-Cell Lymphoma, Nasal Type	5	Observed	clinicaltrials	graph →
→ investigated in trials for	Lymphomacancer_family 5 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Lymphoma	5	Observed	clinicaltrials	graph →
→ investigated in trials for	T Lymphoblastic Lymphoma 5 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	T Lymphoblastic Lymphoma	5	Observed	clinicaltrials	graph →
→ investigated in trials for	Acute Leukemia 4 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Acute Leukemia	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Mixed Phenotype Acute Leukemia 4 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Mixed Phenotype Acute Leukemia	4	Observed	clinicaltrials	graph →

Pegaspargase studied in …STUDIED_INderived10 of 126show all (up to 200)
→ studied in	NCT06124157Phase 2 · recruiting A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL) · 126 trials list this drug (34 active)	—	—	B Acute Lymphoblastic Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT02003222Phase 3 · active not recruiting Combination Chemotherapy With or Without Blinatumomab in Treating Patients With Newly Diagnosed BCR-ABL-Negative B Lineage Acute Lymphoblastic Leukemia · 126 trials list this drug (34 active)	—	—	Acute Lymphoblastic Leukemia,B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative	1	Observed	clinicaltrials	graph →
→ studied in	NCT01920737Phase 2 · active not recruiting A Novel "Pediatric-Inspired" Regimen With Reduced Myelosuppressive Drugs for Adults (Aged 18-60) With Newly Diagnosed Ph Negative Acute Lymphoblastic Leukemia · 126 trials list this drug (34 active)	—	—	Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT04546399Phase 2 · recruiting A Study to Compare Blinatumomab Alone to Blinatumomab With Nivolumab in Patients Diagnosed With First Relapse B-Cell Acute Lymphoblastic Leukemia (B-ALL) · 126 trials list this drug (34 active)	—	—	B Acute Lymphoblastic Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT03959085Phase 3 · recruiting Inotuzumab Ozogamicin and Post-Induction Chemotherapy in Treating Patients With High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and B-LLy · 126 trials list this drug (34 active)	—	—	Central Nervous System Leukemia,Testicular Leukemia,B Acute Lymphoblastic Leukemia+2	1	Observed	clinicaltrials	graph →
→ studied in	NCT05602194Phase 3 · active not recruiting Studying the Effect of Levocarnitine in Protecting the Liver From Chemotherapy for Leukemia or Lymphoma · 126 trials list this drug (34 active)	—	—	Lymphoblastic Lymphoma,B Acute Lymphoblastic Leukemia,T Acute Lymphoblastic Leukemia+2	1	Observed	clinicaltrials	graph →
→ studied in	NCT05254899Phase 2 · completed A Study of Tislelizumab, Chemotherapy, and Radiation Therapy for Early-Stage High-Risk ENKTCL (CLCG-2102) · 126 trials list this drug (34 active)	—	—	Nasal Type Extranodal NK/T-Cell Lymphoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT03007147Phase 3 · active not recruiting Imatinib Mesylate and Combination Chemotherapy in Treating Patients With Newly Diagnosed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia · 126 trials list this drug (34 active)	—	—	Acute Lymphoblastic Leukemia,B Acute Lymphoblastic Leukemia,T Acute Lymphoblastic Leukemia+1	1	Observed	clinicaltrials	graph →
→ studied in	NCT07227584Phase 2 · recruiting ALL Backbone in AYAs · 126 trials list this drug (34 active)	—	—	Leukemia,Acute Lymphoblastic Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT07768943Phase 2 · not yet recruiting GELAD-Based Response-Adapted Treatment for Early-Stage Extranodal NK/T-Cell Lymphoma · 126 trials list this drug (34 active)	—	—	Nasal Type Extranodal NK/T-Cell Lymphoma	1	Observed	clinicaltrials	graph →

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