O6-Benzylguanine

small molecule

Identifier: CI-DRUG-00000414
Entity page: /drug/o6-benzylguanine ↗
Edges: 116

Neighbours: 24 cancers1 variants10 trials
Drawn: 35 of 35 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
O6-Benzylguanine predicts response to …PREDICTS_RESPONSE_TO1 of 1
← predicts response to	MGMT Promoter Methylationepigenetic	sensitivity	E	Glioblastoma	1	Curated	civic	graph →
O6-Benzylguanine investigated for …INVESTIGATED_FOR13 of 13
→ investigated for

O6-Benzylguanine investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 73show all (up to 200)
→ investigated in trials for	Adult Solid Neoplasm 4 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Adult Solid Neoplasm	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Glioblastomasubtype 3 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Glioblastoma	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Primary Cutaneous T-Cell Non-Hodgkin Lymphomahematologic_malignancy 3 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Primary Cutaneous T-Cell Non-Hodgkin Lymphoma	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Adult Hodgkin Lymphoma 2 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Adult Hodgkin Lymphoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Sarcomacancer_family 2 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Sarcoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Adult Burkitt Lymphoma 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Adult Burkitt Lymphoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Adult Glioblastoma 1 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Adult Glioblastoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Adult Grade III Lymphomatoid Granulomatosis 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Adult Grade III Lymphomatoid Granulomatosis	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Adult Immunoblastic Lymphoma 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Adult Immunoblastic Lymphoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Adult Lymphoblastic Lymphoma 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Adult Lymphoblastic Lymphoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Adult Nasal Type Extranodal NK/T-Cell Lymphoma 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Adult Nasal Type Extranodal NK/T-Cell Lymphoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Adult Non-Hodgkin Lymphoma 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Adult Non-Hodgkin Lymphoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Adult T-Cell Leukemia/Lymphoma 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Adult T-Cell Leukemia/Lymphoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	AIDS-Related Immunoblastic Lymphoma 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	AIDS-Related Immunoblastic Lymphoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	AIDS-Related Lymphoblastic Lymphoma 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	AIDS-Related Lymphoblastic Lymphoma	1	Observed	clinicaltrials	graph →

O6-Benzylguanine investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 73show all (up to 200)

→ investigated in trials for

Adult Solid Neoplasm

4 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Adult Solid Neoplasm

Observed

O6-Benzylguanine studied in …STUDIED_INderived10 of 29show all (up to 200)
→ studied in	NCT05052957Phase 2 · recruiting hSTAR GBM (Hematopoetic Stem Cell (HPC) Rescue for GBM) · 29 trials list this drug (1 active)	—	—	Glioblastoma,Adult Glioblastoma,Supratentorial Glioblastoma+1	1	Observed	clinicaltrials	graph →
→ studied in	NCT01269424Phase 1 · completed BG & TMZ Therapy of Glioblastoma Multiforme · 29 trials list this drug (1 active)	—	—	Glioblastoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT00669669Phase 1/Phase 2 · terminated O6-Benzylguanine-Mediated Tumor Sensitization With Chemoprotected Autologous Stem Cell in Treating Patients With Malignant Gliomas · 29 trials list this drug (1 active)	—	—	Glioblastoma,Gliosarcoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT00275002Phase 2 · completed O6-Benzylguanine and Temozolomide in Treating Young Patients With Recurrent or Progressive Gliomas or Brain Stem Tumors · 29 trials list this drug (1 active)	—	—	Central Nervous System Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT02343666Phase 1 · withdrawn HIV-Resistant Gene Modified Stem Cells and Chemotherapy in Treating Patients With Lymphoma With HIV Infection · 29 trials list this drug (1 active)	—	—	Adult Hodgkin Lymphoma,Adult Non-Hodgkin Lymphoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT00002971Phase 1 · completed O(6)-Benzylguanine in Treating Patients With Malignant Glioma · 29 trials list this drug (1 active)	—	—	not mapped	1	Observed	clinicaltrials	graph →
→ studied in	NCT00961220Phase 1/Phase 2 · completed O6-Benzylguanine and Topical Carmustine in Treating Patients With Early-Stage IA-IIA Cutaneous T-Cell Lymphoma · 29 trials list this drug (1 active)	—	—	Primary Cutaneous T-Cell Non-Hodgkin Lymphoma,Mycosis Fungoides and Sezary Syndrome	1	Observed	clinicaltrials	graph →
→ studied in	NCT00436436Phase 2 · terminated O(6)-Benzylguanine and Temozolomide in Treating Patients With Glioblastoma Multiforme That Did Not Respond to Previous Temozolomide and Radiation Therapy · 29 trials list this drug (1 active)	—	—	not mapped	1	Observed	clinicaltrials	graph →
→ studied in	NCT01769911NA · withdrawn Genetically Modified Peripheral Blood Stem Cell Transplant in Treating Patients With HIV-Associated Non-Hodgkin or Hodgkin Lymphoma · 29 trials list this drug (1 active)	—	—	Anaplastic Large Cell Lymphoma,Hairy Cell Leukemia,Non-Hodgkin Lymphoma+2	1	Observed	clinicaltrials	graph →
→ studied in	NCT00020150Phase 1 · completed Temozolomide and O6-benzylguanine in Treating Children With Solid Tumors · 29 trials list this drug (1 active)	—	—	Childhood Germ Cell Tumor,Childhood Solid Neoplasm,Extragonadal Germ Cell Tumor+2	1	Observed	clinicaltrials	graph →

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