Mogamulizumab

monoclonal antibody

Identifier: CI-DRUG-00000752
Entity page: /drug/mogamulizumab ↗
Edges: 69

Neighbours: 17 cancers1 genes10 trials3 approvals
Drawn: 31 of 31 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Mogamulizumab approved for …APPROVED_FORderived3 of 3
→ approved for	Health Canada · CA · 2024Marketed in Canada as POTELIGEO (DIN 02527715) under ATC L01FX09 MOGAMULIZUMAB. Indications are not published in the Drug Product Database — see the Health Canada Product Monograph. Health Canada (CA) · approved · 2024-03-27 · Marketed in Canada as POTELIGEO (DIN 02527715) under ATC L01FX09 MOGAMULIZUMAB. Indications are not published in the Drug Product Database …	—	approved	not mapped	1	Regulatory	health-canada-dpd	open ↗
→ approved for	EMA · EU · 2018

Mogamulizumab targets …TARGETS1 of 1
→ targets	CCR4	—	CROSS-LINKING AGENT	—	1	Curated	chembl	graph →

Mogamulizumab targets …TARGETS1 of 1

→ targets

CCR4

—

CROSS-LINKING AGENT

—

Curated

Mogamulizumab investigated for …INVESTIGATED_FOR10 of 10
→ investigated for	Mycosis Fungoideshematologic_malignancy	unknown	4	Mycosis Fungoides	1	Curated	chembl	graph →
→ investigated for	Sezary Syndromehematologic_malignancy	unknown	4	Sezary Syndrome	1	Curated	chembl	graph →
→ investigated for	Neoplasmcancer_family	unknown	4	Neoplasm	1	Curated	chembl	graph →
→ investigated for	Primary Cutaneous T-Cell Non-Hodgkin Lymphomahematologic_malignancy	unknown	3	Primary Cutaneous T-Cell Non-Hodgkin Lymphoma	1	Curated	chembl	graph →
→ investigated for	Peripheral T-Cell Lymphoma, Not Otherwise Specifiedhematologic_malignancy	unknown	2	Peripheral T-Cell Lymphoma, Not Otherwise Specified	1	Curated	chembl	graph →
→ investigated for	Lymphomacancer_family	unknown	2	Lymphoma	1	Curated	chembl	graph →
→ investigated for	Adult T-Cell Leukemia/Lymphomahematologic_malignancy	unknown	2	Adult T-Cell Leukemia/Lymphoma	1	Curated	chembl	graph →
→ investigated for	Carcinomacancer_family	unknown	1	Carcinoma	1	Curated	chembl	graph →
→ investigated for	Hepatocellular Carcinomasubtype	unknown	1	Hepatocellular Carcinoma	1	Curated	chembl	graph →
→ investigated for	Lung Non-Small Cell Carcinomasubtype	unknown	1	Lung Non-Small Cell Carcinoma	1	Curated	chembl	graph →

Mogamulizumab investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 22show all (up to 200)
→ investigated in trials for	Primary Cutaneous T-Cell Non-Hodgkin Lymphomahematologic_malignancy 9 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Primary Cutaneous T-Cell Non-Hodgkin Lymphoma	9	Observed	clinicaltrials	graph →
→ investigated in trials for	Mycosis Fungoideshematologic_malignancy 8 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Mycosis Fungoides	8	Observed	clinicaltrials	graph →
→ investigated in trials for	Adult T-Cell Leukemia/Lymphomahematologic_malignancy 6 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Adult T-Cell Leukemia/Lymphoma	6	Observed	clinicaltrials	graph →
→ investigated in trials for	Sezary Syndromehematologic_malignancy 6 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Sezary Syndrome	6	Observed	clinicaltrials	graph →
→ investigated in trials for	Solid Neoplasm 4 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Solid Neoplasm	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Mycosis Fungoides and Sezary Syndrome 3 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Mycosis Fungoides and Sezary Syndrome	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Peripheral T-Cell Lymphoma, Not Otherwise Specifiedhematologic_malignancy 2 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Peripheral T-Cell Lymphoma, Not Otherwise Specified	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Carcinomacancer_family 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Carcinoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Diffuse Large B-Cell Lymphoma 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Diffuse Large B-Cell Lymphoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Folliculotropic Mycosis Fungoides 1 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Folliculotropic Mycosis Fungoides	1	Observed	clinicaltrials	graph →
→ investigated in trials for	High Grade B-Cell Lymphoma 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	High Grade B-Cell Lymphoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Lung Non-Small Cell Carcinomasubtype 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Lung Non-Small Cell Carcinoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Lymphomacancer_family 1 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Lymphoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Esophageal Neoplasm 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Esophageal Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Gastric Neoplasm 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Gastric Neoplasm	1	Observed	clinicaltrials	graph →

Mogamulizumab studied in …STUDIED_INderived10 of 33show all (up to 200)
→ studied in	NCT06285370Phase 4 · completed A Study to Evaluate the Efficacy and Safety of KW-0761 in Chinese Subjects With Mycosis Fungoides or Sézary Syndrome Previously Treated With Systemic Therapy · 33 trials list this drug (9 active)	—	—	Primary Cutaneous T-Cell Non-Hodgkin Lymphoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT04930653Phase 2 · recruiting Extracorporeal Photopheresis and Mogamulizumab for the Treatment of Erythrodermic Cutaneous T Cell Lymphoma · 33 trials list this drug (9 active)	—	—	Primary Cutaneous T-Cell Non-Hodgkin Lymphoma,Sezary Syndrome,Mycosis Fungoides and Sezary Syndrome+2	1	Observed	clinicaltrials	graph →
→ studied in	NCT04256018Phase 2 · recruiting Mogamulizumab + Low-Dose Total Skin Electron Beam Tx in Mycosis Fungoides & Sézary Syndrome · 33 trials list this drug (9 active)	—	—	Mycosis Fungoides,Sezary Syndrome	1	Observed	clinicaltrials	graph →
→ studied in	NCT05455931completed Real World Observational Study of Poteligeo in Adult Patients With MF and SS (PROSPER) · 33 trials list this drug (9 active)	—	—	Mycosis Fungoides and Sezary Syndrome	1	Observed	clinicaltrials	graph →
→ studied in	NCT05414500Phase 1 · suspended Mogamulizumab and Brentuximab Vedotin in CTCL and Mycosis Fungoides · 33 trials list this drug (9 active)	—	—	Primary Cutaneous T-Cell Non-Hodgkin Lymphoma,Mycosis Fungoides	1	Observed	clinicaltrials	graph →
→ studied in	NCT05956041Phase 2 · recruiting Pembrolizumab and Mogamulizumab in Advanced-stage, Relapsed/Refractory Cutaneous T-cell Lymphomas · 33 trials list this drug (9 active)	—	—	Primary Cutaneous T-Cell Non-Hodgkin Lymphoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT05996185Phase 2 · recruiting Study of Mogamulizumab With DA-EPOCH or CHOEP in Patients With Aggressive T-cell Lymphoma · 33 trials list this drug (9 active)	—	—	T-Cell Non-Hodgkin Lymphoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07529405Phase 2 · not yet recruiting A Study of VG712 in Patients With Mycosis Fungoides · 33 trials list this drug (9 active)	—	—	Mycosis Fungoides	1	Observed	clinicaltrials	graph →
→ studied in	NCT06698003Phase 2 · recruiting A Study of Mogamulizumab to Prevent Adult T-cell Leukemia/Lymphoma in People With HTLV-1 · 33 trials list this drug (9 active)	—	—	Lymphoma,Adult T-Cell Leukemia/Lymphoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT06235281early Phase 1 · suspended Phototherapy and Mogamulizumab in Early Stage MF (PLIGHT) · 33 trials list this drug (9 active)	—	—	Mycosis Fungoides	1	Observed	clinicaltrials	graph →

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