Izorlisib

small molecule

Identifier: CI-DRUG-00000315
Entity page: /drug/izorlisib ↗
Edges: 20

Neighbours: 5 cancers8 genes2 variants4 trials
Drawn: 19 of 19 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Izorlisib predicts response to …PREDICTS_RESPONSE_TO2 of 2
← predicts response to	PIK3CA H1047RSNV	sensitivity	D	Malignant Breast Neoplasm	1	Curated	civic	graph →
← predicts response to	PIK3CA E542KSNV	sensitivity	D

Izorlisib targets …TARGETS8 of 8
→ targets	PIK3R3	—	INHIBITOR	—	1	Curated	chembl	graph →
→ targets	PIK3CD	—	INHIBITOR	—	1	Curated	chembl	graph →
→ targets	PIK3R2	—	INHIBITOR	—	1	Curated	chembl	graph →
→ targets	PIK3R5	—	INHIBITOR	—	1	Curated	chembl	graph →
→ targets	PIK3CA	—	INHIBITOR	—	1	Curated	chembl	graph →
→ targets	PIK3CB	—	INHIBITOR	—	1	Curated	chembl	graph →
→ targets	PIK3CG	—	INHIBITOR	—	1	Curated	chembl	graph →
→ targets	PIK3R1	—	INHIBITOR	—	1	Curated	chembl	graph →

Izorlisib targets …TARGETS8 of 8

→ targets

PIK3R3

—

INHIBITOR

—

Curated

Izorlisib investigated for …INVESTIGATED_FOR2 of 2
→ investigated for	Malignant Breast Neoplasmcancer_family 2 source records aggregated	supports	D	Malignant Breast Neoplasm	2	Curated	civic	graph →
→ investigated for	Neoplasmcancer_family	unknown	2	Neoplasm	1	Curated	chembl	graph →

Izorlisib investigated in trials for …INVESTIGATED_IN_TRIALSderived4 of 4
→ investigated in trials for	Breast Neoplasm 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Breast Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Breast Neoplasmcancer_family 1 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Breast Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Colorectal Neoplasm 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Colorectal Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Solid Neoplasm 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Solid Neoplasm	1	Observed	clinicaltrials	graph →

Izorlisib studied in …STUDIED_INderived4 of 4
→ studied in	NCT05810870Phase 2 · active not recruiting PIK3CA/PTEN-altered Advanced Breast Cancer Treated With MEN1611 Monotherapy or in Combination With Eribulin · 4 trials list this drug (1 active)	—	—	Malignant Breast Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT03767335Phase 1 · completed MEN1611 With Trastuzumab (+/- Fulvestrant) in Metastatic Breast Cancer · 4 trials list this drug (1 active)	—	—	Breast Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT04495621Phase 1/Phase 2 · completed MEN1611 With Cetuximab in Metastatic Colorectal Cancer (C-PRECISE-01) · 4 trials list this drug (1 active)	—	—	Malignant Colorectal Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT01222546Phase 1 · completed Study of CH5132799 Administered Orally in Patients With Advanced Solid Tumors · 4 trials list this drug (1 active)	—	—	Solid Neoplasm	1	Observed	clinicaltrials	graph →

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