FOLFOX-4 Regimen

Identifier: CI-DRUG-00000241
Entity page: /drug/folfox-4-regimen ↗
Edges: 21

Neighbours: 5 cancers2 variants10 trials
Drawn: 17 of 17 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
FOLFOX-4 Regimen predicts response to …PREDICTS_RESPONSE_TO2 of 2
← predicts response to	KRAS A146TSNV	resistance	B	Malignant Colorectal Neoplasm	1	Curated	civic	graph →
← predicts response to	BRAF V600ESNV	resistance	B

FOLFOX-4 Regimen investigated for …INVESTIGATED_FOR1 of 1
→ investigated for	Malignant Colorectal Neoplasmsubtype 2 source records aggregated	supports	B	Malignant Colorectal Neoplasm	2	Curated	civic	graph →

FOLFOX-4 Regimen investigated in trials for …INVESTIGATED_IN_TRIALSderived5 of 5
→ investigated in trials for	Hepatocellular Carcinoma 7 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Hepatocellular Carcinoma	7	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Colorectal Neoplasmsubtype 2 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Colorectal Neoplasm	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Biliary Tract Carcinoma 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Biliary Tract Carcinoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Rectal Neoplasm 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Rectal Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Rectal Carcinoma 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Rectal Carcinoma	1	Observed	clinicaltrials	graph →

FOLFOX-4 Regimen studied in …STUDIED_INderived10 of 13show all (up to 200)
→ studied in	NCT03092895Phase 2 · completed A Study of SHR-1210 in Combination With Apatinib or Chemotherapy in Subjects With Advanced PLC or BTC · 13 trials list this drug (2 active)	—	—	Biliary Tract Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT06893887NA · recruiting Individualized Comprehensive Treatment for Advanced Hepatocellular Carcinoma · 13 trials list this drug (2 active)	—	—	Hepatocellular Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT02000050Phase 2 · completed Phase II Study of Up-front Chemotherapy and Neo-adjuvant Short-course Radiotherapy for Resectable Rectal Carcinoma (COLORE) · 13 trials list this drug (2 active)	—	—	Rectal Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT05912075Phase 1 · recruiting Preoperative Radiotherapy And ASTX660 in Rectum Cancer · 13 trials list this drug (2 active)	—	—	not mapped	1	Observed	clinicaltrials	graph →
→ studied in	NCT03605706Phase 3 · unknown A Trial of SHR-1210 (an Anti-PD-1 Inhibitor) in Combination With FOLFOX4 in Subjects With Advanced HCC Who Have Never Received Prior Systemic Treatment. · 13 trials list this drug (2 active)	—	—	Hepatocellular Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT04521491NA · unknown A Trial of Adjuvant Therapy After Hepatocarcinoma Resection Based on Folate Receptor-positive Circulating Tumor Cells · 13 trials list this drug (2 active)	—	—	Hepatocellular Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT00580073Phase 2 · terminated Phase II Trial of Neoadjuvant FOLFOX4 and Cetuximab for Localized Adenocarcinoma of Rectum · 13 trials list this drug (2 active)	—	—	Malignant Rectal Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT02527772Phase 2/Phase 3 · withdrawn Liposomal Doxorubicin Plus Gemcitabine Versus Oxaliplatin Plus Fluorouracil/Leucovorin for Hepatocellular Carcinoma · 13 trials list this drug (2 active)	—	—	Hepatocellular Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT02534337Phase 2/Phase 3 · withdrawn Gemcitabine Plus Oxaliplatin Versus Oxaliplatin Plus Fluorouracil/Leucovorin for Hepatocellular Carcinoma · 13 trials list this drug (2 active)	—	—	Hepatocellular Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT02069041Phase 1 · completed A Study of Ramucirumab (LY3009806) in Participants With Advanced Liver Cancer · 13 trials list this drug (2 active)	—	—	Hepatocellular Carcinoma	1	Observed	clinicaltrials	graph →

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