Conatumumab

monoclonal antibody

Identifier: CI-DRUG-00000162
Entity page: /drug/conatumumab ↗
Edges: 41

Neighbours: 19 cancers1 genes1 variants11 trials
Drawn: 32 of 32 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Conatumumab predicts response to …PREDICTS_RESPONSE_TO1 of 1
← predicts response to	CASP8 Overexpressionexpression	sensitivity	D	Bone Ewing Sarcoma	1	Curated	civic	graph →
Conatumumab targets …TARGETS1 of 1
→ targets

Conatumumab investigated for …INVESTIGATED_FOR10 of 10
→ investigated for	Bone Ewing Sarcomasubtype	supports	D	Bone Ewing Sarcoma	1	Curated	civic	graph →
→ investigated for	Non-Hodgkin Lymphomahematologic_malignancy	unknown	1	Non-Hodgkin Lymphoma	1	Curated	chembl	graph →
→ investigated for	Lymphomacancer_family	unknown	1	Lymphoma	1	Curated	chembl	graph →
→ investigated for	Fallopian Tube Neoplasmsubtype	unknown	1	Fallopian Tube Neoplasm	1	Curated	chembl	graph →
→ investigated for	Ovarian Neoplasmsubtype	unknown	1	Ovarian Neoplasm	1	Curated	chembl	graph →
→ investigated for	Sarcomacancer_family	unknown	1	Sarcoma	1	Curated	chembl	graph →
→ investigated for	Pancreatic Neoplasmsubtype	unknown	1	Pancreatic Neoplasm	1	Curated	chembl	graph →
→ investigated for	Mantle Cell Lymphomahematologic_malignancy	unknown	1	Mantle Cell Lymphoma	1	Curated	chembl	graph →
→ investigated for	Hodgkin Lymphomahematologic_malignancy	unknown	1	Hodgkin Lymphoma	1	Curated	chembl	graph →
→ investigated for	Lung Non-Small Cell Carcinomasubtype	unknown	1	Lung Non-Small Cell Carcinoma	1	Curated	chembl	graph →

Conatumumab investigated for …INVESTIGATED_FOR10 of 10

→ investigated for

Bone Ewing Sarcomasubtype

supports

Bone Ewing Sarcoma

Curated

Conatumumab investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 18show all (up to 200)
→ investigated in trials for	Malignant Colorectal Neoplasm 5 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Colorectal Neoplasm	5	Observed	clinicaltrials	graph →
→ investigated in trials for	Lung Non-Small Cell Carcinomasubtype 3 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Lung Non-Small Cell Carcinoma	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Pancreatic Neoplasm 3 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Pancreatic Neoplasm	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Sarcomacancer_family 3 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Sarcoma	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Lymphomacancer_family 2 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Lymphoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Colon Neoplasm 2 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Colon Neoplasm	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Neoplasm 2 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Neoplasm	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Rectal Neoplasm 2 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Rectal Neoplasm	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Solid Neoplasm 2 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Solid Neoplasm	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Hodgkin Lymphomahematologic_malignancy 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Hodgkin Lymphoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Fallopian Tube Neoplasm 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Fallopian Tube Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Ovarian Neoplasm 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Ovarian Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Mantle Cell Lymphomahematologic_malignancy 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Mantle Cell Lymphoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Neuroendocrine Tumor 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Neuroendocrine Tumor	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Non-Hodgkin Lymphomahematologic_malignancy 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Non-Hodgkin Lymphoma	1	Observed	clinicaltrials	graph →

Conatumumab studied in …STUDIED_INderived11 of 11show fewer
→ studied in	NCT00630552Phase 1/Phase 2 · completed QUILT-2.019: A Study of AMG 655 or AMG 479 in Combination With Gemcitabine for Treatment of Metastatic Pancreatic Cancer · 11 trials list this drug (0 active)	—	—	Malignant Pancreatic Neoplasm,Pancreatic Adenocarcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT00819169Phase 1/Phase 2 · terminated QUILT-3.026: AMG 655 in Combination With AMG 479 in Advanced, Refractory Solid Tumors · 11 trials list this drug (0 active)	—	—	Malignant Neoplasm,Solid Neoplasm,Sarcoma+2	1	Observed	clinicaltrials	graph →
→ studied in	NCT01327612Phase 2 · completed Open Label Extension Study of Conatumumab and Ganitumab (AMG 479) · 11 trials list this drug (0 active)	—	—	Malignant Neoplasm,Solid Neoplasm,Lymphoma+2	1	Observed	clinicaltrials	graph →
→ studied in	NCT00813605Phase 2 · completed QUILT-2.018: Safety & Efficacy of FOLFIRI With AMG 479 or AMG 655 vs FOLFIRI Alone in KRAS-mutant Metastatic Colorectal Carcinoma · 11 trials list this drug (0 active)	—	—	Malignant Colorectal Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT00534027Phase 1/Phase 2 · completed A Phase 1b/2 Study of AMG 655 in Combination With Paclitaxel and Carboplatin for the First-Line Treatment of Advanced Non-Small Cell Lung Cancer · 11 trials list this drug (0 active)	—	—	Lung Non-Small Cell Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT01940172Phase 1 · completed Study of Birinapant in Combination With Conatumumab in Subjects With Relapsed Ovarian Cancer · 11 trials list this drug (0 active)	—	—	Malignant Fallopian Tube Neoplasm,Ovarian Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT00626704Phase 1/Phase 2 · completed Phase 1b/2 Study of AMG 655 With Doxorubicin for the First-Line Treatment of Unresectable Soft Tissue Sarcoma · 11 trials list this drug (0 active)	—	—	Sarcoma,Soft Tissue Sarcoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT00625651Phase 1/Phase 2 · completed Phase 1b/2 Study of AMG 655 With mFOLFOX6 and Bevacizumab for First-Line Metastatic Colorectal Cancer · 11 trials list this drug (0 active)	—	—	Malignant Colorectal Neoplasm,Malignant Colon Neoplasm,Malignant Rectal Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT00791011Phase 1 · completed Phase 1b Lymphoma Study of AMG 655 in Combination With Bortezomib or Vorinostat · 11 trials list this drug (0 active)	—	—	Lymphoma,Hodgkin Lymphoma,Non-Hodgkin Lymphoma+1	1	Observed	clinicaltrials	graph →
→ studied in	NCT00630786Phase 1/Phase 2 · completed Conatumumab/Panitumumab Combination Metastatic Colorectal Cancer Study · 11 trials list this drug (0 active)	—	—	Malignant Colorectal Neoplasm,Malignant Colon Neoplasm,Malignant Rectal Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT01017822Phase 1/Phase 2 · withdrawn Conatumumab, Gemcitabine Hydrochloride, Capecitabine, and Radiation Therapy in Treating Patients With Locally Advanced Pancreatic Cancer · 11 trials list this drug (0 active)	—	—	Malignant Pancreatic Neoplasm	1	Observed	clinicaltrials	graph →

Radial view

Every edge, grouped by relationship

Paths