Chemotherapy

Identifier: CI-DRUG-00000154
Entity page: /drug/chemotherapy ↗
Edges: 888

Neighbours: 20 cancers15 variants10 trials
Drawn: 45 of 45 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Chemotherapy predicts response to …PREDICTS_RESPONSE_TO15 of 23show all (up to 200)
← predicts response to	EGFR Exon 20 Insertioninsertion	sensitivity	A	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
← predicts response to	EGFR Exon 19 Deletiondeletion

Chemotherapy investigated for …INVESTIGATED_FOR9 of 9
→ investigated for	Lung Non-Small Cell Carcinomasubtype 2 source records aggregated	supports	A	Lung Non-Small Cell Carcinoma	2	Curated	civic	graph →
→ investigated for	Malignant Colorectal Neoplasmsubtype 9 source records aggregated	supports	B	Malignant Colorectal Neoplasm	9	Curated	civic	graph →
→ investigated for	Lung Small Cell Carcinomasubtype	supports	B	Lung Small Cell Carcinoma	1	Curated	civic	graph →
→ investigated for	Gastric Carcinomasubtype	supports	B	Gastric Carcinoma	1	Curated	civic	graph →
→ investigated for	Esophageal Carcinomasubtype	supports	B	Esophageal Carcinoma	1	Curated	civic	graph →
→ investigated for	Gastric Adenocarcinomasubtype	supports	B	Gastric Adenocarcinoma	1	Curated	civic	graph →
→ investigated for	Lung Non-Small Cell Carcinomasubtype	supports	B	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ investigated for	Malignant Colorectal Neoplasmsubtype 6 source records aggregated	supports	C	Malignant Colorectal Neoplasm	6	Curated	civic	graph →
→ investigated for	B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Likehematologic_malignancy	supports	C	B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like	1	Curated	civic	graph →

Chemotherapy investigated for …INVESTIGATED_FOR9 of 9

→ investigated for

Lung Non-Small Cell Carcinomasubtype

2 source records aggregated

supports

Lung Non-Small Cell Carcinoma

Curated

Chemotherapy investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 238show all (up to 200)
→ investigated in trials for	Lung Non-Small Cell Carcinomasubtype 74 trials (27 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Lung Non-Small Cell Carcinoma	74	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Breast Neoplasm 51 trials (13 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Breast Neoplasm	51	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Colorectal Neoplasmsubtype 41 trials (11 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Colorectal Neoplasm	41	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Ovarian Neoplasm 29 trials (10 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Ovarian Neoplasm	29	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Gastric Neoplasm 27 trials (13 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Gastric Neoplasm	27	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Lung Neoplasm 24 trials (8 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Lung Neoplasm	24	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Neoplasm 19 trials (6 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Neoplasm	19	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Rectal Neoplasm 19 trials (12 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Rectal Neoplasm	19	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Pancreatic Neoplasm 18 trials (9 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Pancreatic Neoplasm	18	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Esophageal Neoplasm 17 trials (8 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Esophageal Neoplasm	17	Observed	clinicaltrials	graph →
→ investigated in trials for	Colorectal Neoplasm 15 trials (6 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Colorectal Neoplasm	15	Observed	clinicaltrials	graph →
→ investigated in trials for	Solid Neoplasm 15 trials (9 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Solid Neoplasm	15	Observed	clinicaltrials	graph →
→ investigated in trials for	Esophageal Squamous Cell Carcinoma 13 trials (10 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Esophageal Squamous Cell Carcinoma	13	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Fallopian Tube Neoplasm 13 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Fallopian Tube Neoplasm	13	Observed	clinicaltrials	graph →
→ investigated in trials for	Breast Neoplasm 12 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Breast Neoplasm	12	Observed	clinicaltrials	graph →

Chemotherapy studied in …STUDIED_INderived10 of 618show all (up to 200)
→ studied in	NCT05981703Phase 1 · recruiting A Study Investigating BGB-26808 Alone or in Combination With Tislelizumab in Participants With Advanced Solid Tumors · 618 trials list this drug (227 active)	—	—	Solid Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT07222800Phase 3 · recruiting Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer · 618 trials list this drug (227 active)	—	—	Neoplasm by Site,Digestive System Neoplasm,Intestinal Neoplasm+1	1	Observed	clinicaltrials	graph →
→ studied in	NCT07226999Phase 2/Phase 3 · recruiting Symbiotic-Lung-04: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Extensive-Stage Small Cell Lung Cancer · 618 trials list this drug (227 active)	—	—	Lung Small Cell Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07391774Phase 3 · recruiting Testing Whether Hormone Therapy With Ribociclib is as Effective as Chemotherapy Followed by Hormone Therapy With Ribociclib for the Treatment of High Anatomic Stage Breast Cancer With Low Recurrence Risk, The RxFINE-Low Trial · 618 trials list this drug (227 active)	—	—	HER2-Negative Breast Carcinoma,Estrogen Receptor-Positive Breast Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07392892Phase 2/Phase 3 · recruiting Symbiotic-GI-16: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Gastroesophageal Cancer · 618 trials list this drug (227 active)	—	—	Malignant Gastric Neoplasm,Esophageal Adenocarcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07476287Phase 2 · recruiting Symbiotic-Lung-14: A Study to Learn About the Study Medicine Called PF08634404 in Combination With Chemotherapy in Adult Participants With Transformed Small Cell Lung Cancer · 618 trials list this drug (227 active)	—	—	Lung Neoplasm,Lung Small Cell Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT02392429Phase 2 · active not recruiting FLT PET/CT in Measuring Response in Patients With Previously Untreated Acute Myeloid Leukemia · 618 trials list this drug (227 active)	—	—	Acute Myeloid Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT07835893Phase 2 · recruiting Lenvatinib Plus Chemotherapy for pNET Liver Metastases · 618 trials list this drug (227 active)	—	—	not mapped	1	Observed	clinicaltrials	graph →
→ studied in	NCT04638751suspended ARGONAUT: Stool and Blood Sample Bank for Cancer Patients · 618 trials list this drug (227 active)	—	—	Lung Non-Small Cell Carcinoma,Pancreatic Carcinoma,Malignant Colorectal Neoplasm+1	1	Observed	clinicaltrials	graph →
→ studied in	NCT07044362NA · recruiting Histotripsy Plus Chemotherapy vs Chemotherapy Alone for Advanced Colorectal Liver Metastasis · 618 trials list this drug (227 active)	—	—	Malignant Liver Neoplasm,Malignant Colorectal Neoplasm	1	Observed	clinicaltrials	graph →

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