Adagrasib

small molecule

Identifier: CI-DRUG-00000038
Entity page: /drug/adagrasib ↗
Edges: 64

Neighbours: 16 cancers1 genes1 variants10 trials2 approvals
Drawn: 30 of 30 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Adagrasib approved for …APPROVED_FOR5 of 3
→ approved for	Malignant Colorectal Neoplasmsubtype	supports	FDA ORIG	Malignant Colorectal Neoplasm	1	Regulatory	openfda	graph →
→ approved for	Lung Non-Small Cell Carcinomasubtype	supports	FDA ORIG

Adagrasib predicts response to …PREDICTS_RESPONSE_TO2 of 2
← predicts response to	KRAS G12CSNV	sensitivity	A	Malignant Colorectal Neoplasm	1	Curated	civic	graph →
← predicts response to	KRAS G12CSNV	sensitivity	D	Solid Neoplasm	1	Curated	civic	graph →

Adagrasib predicts response to …PREDICTS_RESPONSE_TO2 of 2

← predicts response to

KRAS G12CSNV

sensitivity

Malignant Colorectal Neoplasm

Curated

Adagrasib investigated for …INVESTIGATED_FOR7 of 7
→ investigated for	Malignant Colorectal Neoplasmsubtype	supports	A	Malignant Colorectal Neoplasm	1	Curated	civic	graph →
→ investigated for	Neoplasmcancer_family	unknown	4	Neoplasm	1	Curated	chembl	graph →
→ investigated for	Lung Non-Small Cell Carcinomasubtype	unknown	4	Lung Non-Small Cell Carcinoma	1	Curated	chembl	graph →
→ investigated for	Solid Neoplasmcancer_family	supports	D	Solid Neoplasm	1	Curated	civic	graph →
→ investigated for	Pancreatic Neoplasmsubtype	unknown	1	Pancreatic Neoplasm	1	Curated	chembl	graph →
→ investigated for	Colorectal Neoplasmsubtype	unknown	1	Colorectal Neoplasm	1	Curated	chembl	graph →
→ investigated for	Lung Neoplasmcancer_family	unknown	1	Lung Neoplasm	1	Curated	chembl	graph →

Adagrasib investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 17show all (up to 200)
→ investigated in trials for	Lung Non-Small Cell Carcinomasubtype 14 trials (10 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Lung Non-Small Cell Carcinoma	14	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Neoplasm 7 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Neoplasm	7	Observed	clinicaltrials	graph →
→ investigated in trials for	Solid Neoplasmcancer_family 6 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Solid Neoplasm	6	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Colorectal Neoplasmsubtype 5 trials (5 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Colorectal Neoplasm	5	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Lung Neoplasm 5 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Lung Neoplasm	5	Observed	clinicaltrials	graph →
→ investigated in trials for	Lung Neoplasmcancer_family 2 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Lung Neoplasm	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Colon Neoplasm 2 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Colon Neoplasm	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Adult Solid Neoplasm 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Adult Solid Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Brain Neoplasm 1 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Brain Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Clear Cell Renal Cell Carcinoma 1 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Clear Cell Renal Cell Carcinoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Colorectal Neoplasmsubtype 1 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Colorectal Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Pancreatic Neoplasm 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Pancreatic Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Solid Neoplasm 1 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Solid Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Neoplasmcancer_family 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Non-Clear Cell Renal Cell Carcinoma 1 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Non-Clear Cell Renal Cell Carcinoma	1	Observed	clinicaltrials	graph →

Adagrasib studied in …STUDIED_INderived10 of 34show all (up to 200)
→ studied in	NCT03994796Phase 2 · active not recruiting Genetic Testing in Guiding Treatment for Patients With Brain Metastases · 34 trials list this drug (19 active)	—	—	Malignant Solid Neoplasm,Brain Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT04793958Phase 3 · active not recruiting Phase 3 Study of MRTX849 With Cetuximab vs Chemotherapy in Patients With Advanced Colorectal Cancer With KRAS G12C Mutation (KRYSTAL-10) · 34 trials list this drug (19 active)	—	—	Malignant Colorectal Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT06875310Phase 3 · recruiting A Study of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4) · 34 trials list this drug (19 active)	—	—	Lung Non-Small Cell Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07415031Phase 2 · recruiting A Solid Tumor Study for Long Term Treatment of Cancer Patients Who Participated in Adagrasib Studies · 34 trials list this drug (19 active)	—	—	Solid Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT04613596Phase 2/Phase 3 · recruiting Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7 · 34 trials list this drug (19 active)	—	—	Lung Non-Small Cell Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT06497556Phase 3 · active not recruiting A Study Evaluating the Efficacy and Safety of Divarasib Versus Sotorasib or Adagrasib in Participants With Previously Treated KRAS G12C-positive Advanced or Metastatic Non-Small Cell Lung Cancer · 34 trials list this drug (19 active)	—	—	Lung Neoplasm,Lung Non-Small Cell Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT06039384Phase 1 · terminated A Study of INCB099280 in Combination With Adagrasib in Adults With Advanced Solid Tumors Harboring a KRASG12C Mutation · 34 trials list this drug (19 active)	—	—	Solid Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT05673187Phase 2 · active not recruiting Adagrasib in Patients With KRASG12C-mutant NSCLC Who Are Elderly or Have Poor Performance Status · 34 trials list this drug (19 active)	—	—	Lung Non-Small Cell Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07543172Phase 2 · not yet recruiting CIMAvax-EGF With KRAS G12C Inhibitor for the Treatment of Advanced, KRAS G12C Mutated Non Small Cell Lung Cancer · 34 trials list this drug (19 active)	—	—	Malignant Lung Neoplasm,Lung Non-Small Cell Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT05722327Phase 1 · active not recruiting Phase I Trial of Adagrasib (MRTX849) in Combination With Cetuximab and Irinotecan in Patients With Colorectal Cancer · 34 trials list this drug (19 active)	—	—	Malignant Colorectal Neoplasm,Malignant Colon Neoplasm	1	Observed	clinicaltrials	graph →

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